Cytisine-N-methylene-(5,7,4 < sup > ' < /sup > -trihydroxy)- isoflavone ameliorates ischemic stroke-induced brain injury in mouse by regulating the oxidative stress and BDNF-Trkb/Akt pathway

CONCLUSIONS: Our study suggests that LY01 reversed ischemic stroke by reducing oxidative stress and activating the BDNF-TrkB/Akt pathway and exerted a neuroprotective action against OGD/R injury via attenuation, a novel approach was suggested to treat ischemic stroke. Our observations justify the traditional use of LY01 for a treatment of IS in nervous system.PMID:38493912 | DOI:10.1016/j.ejphar.2024.176512
Source: European Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Source Type: research