Physics of collective cell migration
Eur Biophys J. 2023 Sep 14. doi: 10.1007/s00249-023-01681-w. Online ahead of print.ABSTRACTMovement of cell clusters along extracellular matrices (ECM) during tissue development, wound healing, and early stage of cancer invasion involve various inter-connected migration modes such as: (1) cell movement within clusters, (2) cluster extension (wetting) and compression (de-wetting), and (3) directional cluster movement. It has become increasingly evident that dilational and volumetric viscoelasticity of cell clusters and their surrounding substrate significantly influence these migration modes through physical parameters such...
Source: European Biophysics Journal : EBJ - September 14, 2023 Category: Physics Authors: Ivana Pajic-Lijakovic Milan Milivojevic Source Type: research
Physics of collective cell migration
Eur Biophys J. 2023 Sep 14. doi: 10.1007/s00249-023-01681-w. Online ahead of print.ABSTRACTMovement of cell clusters along extracellular matrices (ECM) during tissue development, wound healing, and early stage of cancer invasion involve various inter-connected migration modes such as: (1) cell movement within clusters, (2) cluster extension (wetting) and compression (de-wetting), and (3) directional cluster movement. It has become increasingly evident that dilational and volumetric viscoelasticity of cell clusters and their surrounding substrate significantly influence these migration modes through physical parameters such...
Source: European Biophysics Journal : EBJ - September 14, 2023 Category: Physics Authors: Ivana Pajic-Lijakovic Milan Milivojevic Source Type: research
Physics of collective cell migration
Eur Biophys J. 2023 Sep 14. doi: 10.1007/s00249-023-01681-w. Online ahead of print.ABSTRACTMovement of cell clusters along extracellular matrices (ECM) during tissue development, wound healing, and early stage of cancer invasion involve various inter-connected migration modes such as: (1) cell movement within clusters, (2) cluster extension (wetting) and compression (de-wetting), and (3) directional cluster movement. It has become increasingly evident that dilational and volumetric viscoelasticity of cell clusters and their surrounding substrate significantly influence these migration modes through physical parameters such...
Source: European Biophysics Journal : EBJ - September 14, 2023 Category: Physics Authors: Ivana Pajic-Lijakovic Milan Milivojevic Source Type: research
Physics of collective cell migration
Eur Biophys J. 2023 Sep 14. doi: 10.1007/s00249-023-01681-w. Online ahead of print.ABSTRACTMovement of cell clusters along extracellular matrices (ECM) during tissue development, wound healing, and early stage of cancer invasion involve various inter-connected migration modes such as: (1) cell movement within clusters, (2) cluster extension (wetting) and compression (de-wetting), and (3) directional cluster movement. It has become increasingly evident that dilational and volumetric viscoelasticity of cell clusters and their surrounding substrate significantly influence these migration modes through physical parameters such...
Source: European Biophysics Journal : EBJ - September 14, 2023 Category: Physics Authors: Ivana Pajic-Lijakovic Milan Milivojevic Source Type: research
MIL-CELL: a tool for multi-scale simulation of yeast replication and prion transmission
We describe the workings of the model, assumptions upon which it is based and some interesting simulation results pertaining to the wave-like spread of the epigenetic prion elements through the yeast population. MIL-CELL is provided as a stand-alone GUI executable program for free download with the paper. MIL-CELL is equipped with a relational database allowing all simulated properties to be searched, collated and graphed. Its ability to incorporate variation in heritable properties means MIL-CELL is also capable of simulating loss of the isogenic nature of a cell population over time. The capability to monitor both chrono...
Source: European Biophysics Journal : EBJ - September 5, 2023 Category: Physics Authors: Damien Hall Source Type: research
MIL-CELL: a tool for multi-scale simulation of yeast replication and prion transmission
We describe the workings of the model, assumptions upon which it is based and some interesting simulation results pertaining to the wave-like spread of the epigenetic prion elements through the yeast population. MIL-CELL is provided as a stand-alone GUI executable program for free download with the paper. MIL-CELL is equipped with a relational database allowing all simulated properties to be searched, collated and graphed. Its ability to incorporate variation in heritable properties means MIL-CELL is also capable of simulating loss of the isogenic nature of a cell population over time. The capability to monitor both chrono...
Source: European Biophysics Journal : EBJ - September 5, 2023 Category: Physics Authors: Damien Hall Source Type: research
MIL-CELL: a tool for multi-scale simulation of yeast replication and prion transmission
We describe the workings of the model, assumptions upon which it is based and some interesting simulation results pertaining to the wave-like spread of the epigenetic prion elements through the yeast population. MIL-CELL is provided as a stand-alone GUI executable program for free download with the paper. MIL-CELL is equipped with a relational database allowing all simulated properties to be searched, collated and graphed. Its ability to incorporate variation in heritable properties means MIL-CELL is also capable of simulating loss of the isogenic nature of a cell population over time. The capability to monitor both chrono...
Source: European Biophysics Journal : EBJ - September 5, 2023 Category: Physics Authors: Damien Hall Source Type: research
MIL-CELL: a tool for multi-scale simulation of yeast replication and prion transmission
We describe the workings of the model, assumptions upon which it is based and some interesting simulation results pertaining to the wave-like spread of the epigenetic prion elements through the yeast population. MIL-CELL is provided as a stand-alone GUI executable program for free download with the paper. MIL-CELL is equipped with a relational database allowing all simulated properties to be searched, collated and graphed. Its ability to incorporate variation in heritable properties means MIL-CELL is also capable of simulating loss of the isogenic nature of a cell population over time. The capability to monitor both chrono...
Source: European Biophysics Journal : EBJ - September 5, 2023 Category: Physics Authors: Damien Hall Source Type: research
MIL-CELL: a tool for multi-scale simulation of yeast replication and prion transmission
We describe the workings of the model, assumptions upon which it is based and some interesting simulation results pertaining to the wave-like spread of the epigenetic prion elements through the yeast population. MIL-CELL is provided as a stand-alone GUI executable program for free download with the paper. MIL-CELL is equipped with a relational database allowing all simulated properties to be searched, collated and graphed. Its ability to incorporate variation in heritable properties means MIL-CELL is also capable of simulating loss of the isogenic nature of a cell population over time. The capability to monitor both chrono...
Source: European Biophysics Journal : EBJ - September 5, 2023 Category: Physics Authors: Damien Hall Source Type: research
MIL-CELL: a tool for multi-scale simulation of yeast replication and prion transmission
We describe the workings of the model, assumptions upon which it is based and some interesting simulation results pertaining to the wave-like spread of the epigenetic prion elements through the yeast population. MIL-CELL is provided as a stand-alone GUI executable program for free download with the paper. MIL-CELL is equipped with a relational database allowing all simulated properties to be searched, collated and graphed. Its ability to incorporate variation in heritable properties means MIL-CELL is also capable of simulating loss of the isogenic nature of a cell population over time. The capability to monitor both chrono...
Source: European Biophysics Journal : EBJ - September 5, 2023 Category: Physics Authors: Damien Hall Source Type: research
MIL-CELL: a tool for multi-scale simulation of yeast replication and prion transmission
We describe the workings of the model, assumptions upon which it is based and some interesting simulation results pertaining to the wave-like spread of the epigenetic prion elements through the yeast population. MIL-CELL is provided as a stand-alone GUI executable program for free download with the paper. MIL-CELL is equipped with a relational database allowing all simulated properties to be searched, collated and graphed. Its ability to incorporate variation in heritable properties means MIL-CELL is also capable of simulating loss of the isogenic nature of a cell population over time. The capability to monitor both chrono...
Source: European Biophysics Journal : EBJ - September 5, 2023 Category: Physics Authors: Damien Hall Source Type: research
N2 modified cap analogues as translation inhibitors and substrates for preparation of therapeutic mRNA
Eur Biophys J. 2023 Sep 1. doi: 10.1007/s00249-023-01676-7. Online ahead of print.ABSTRACTIn recent years many scientists have begun to focus on the mRNA molecule's emeregence as a new type of drug. Its fast-moving and successful career as a vaccine technology cannot be underestimated. mRNA provides new opportunities and allows for the rapid preparation of effective drugs at low cost. These extensive possibilities stem from a number of factors, but the small cap structure located at the 5' end of the mRNA is one contributing factor. Cap protects mRNA and ensures efficient recruitment to the biosynthesis machinery. Furtherm...
Source: European Biophysics Journal : EBJ - September 1, 2023 Category: Physics Authors: Karol Kurpiejewski Marzena Jankowska-Anyszka Renata Grzela Source Type: research
N2 modified cap analogues as translation inhibitors and substrates for preparation of therapeutic mRNA
Eur Biophys J. 2023 Sep 1. doi: 10.1007/s00249-023-01676-7. Online ahead of print.ABSTRACTIn recent years many scientists have begun to focus on the mRNA molecule's emeregence as a new type of drug. Its fast-moving and successful career as a vaccine technology cannot be underestimated. mRNA provides new opportunities and allows for the rapid preparation of effective drugs at low cost. These extensive possibilities stem from a number of factors, but the small cap structure located at the 5' end of the mRNA is one contributing factor. Cap protects mRNA and ensures efficient recruitment to the biosynthesis machinery. Furtherm...
Source: European Biophysics Journal : EBJ - September 1, 2023 Category: Physics Authors: Karol Kurpiejewski Marzena Jankowska-Anyszka Renata Grzela Source Type: research
N2 modified cap analogues as translation inhibitors and substrates for preparation of therapeutic mRNA
Eur Biophys J. 2023 Sep 1. doi: 10.1007/s00249-023-01676-7. Online ahead of print.ABSTRACTIn recent years many scientists have begun to focus on the mRNA molecule's emeregence as a new type of drug. Its fast-moving and successful career as a vaccine technology cannot be underestimated. mRNA provides new opportunities and allows for the rapid preparation of effective drugs at low cost. These extensive possibilities stem from a number of factors, but the small cap structure located at the 5' end of the mRNA is one contributing factor. Cap protects mRNA and ensures efficient recruitment to the biosynthesis machinery. Furtherm...
Source: European Biophysics Journal : EBJ - September 1, 2023 Category: Physics Authors: Karol Kurpiejewski Marzena Jankowska-Anyszka Renata Grzela Source Type: research
N2 modified cap analogues as translation inhibitors and substrates for preparation of therapeutic mRNA
Eur Biophys J. 2023 Sep 1. doi: 10.1007/s00249-023-01676-7. Online ahead of print.ABSTRACTIn recent years many scientists have begun to focus on the mRNA molecule's emeregence as a new type of drug. Its fast-moving and successful career as a vaccine technology cannot be underestimated. mRNA provides new opportunities and allows for the rapid preparation of effective drugs at low cost. These extensive possibilities stem from a number of factors, but the small cap structure located at the 5' end of the mRNA is one contributing factor. Cap protects mRNA and ensures efficient recruitment to the biosynthesis machinery. Furtherm...
Source: European Biophysics Journal : EBJ - September 1, 2023 Category: Physics Authors: Karol Kurpiejewski Marzena Jankowska-Anyszka Renata Grzela Source Type: research
