Diversity of hydrodynamic radii of intrinsically disordered proteins
Eur Biophys J. 2023 Oct 13. doi: 10.1007/s00249-023-01683-8. Online ahead of print.ABSTRACTIntrinsically disordered proteins (IDPs) form an important class of biomolecules regulating biological processes in higher organisms. The lack of a fixed spatial structure facilitates them to perform their regulatory functions and allows the efficiency of biochemical reactions to be controlled by temperature and the cellular environment. From the biophysical point of view, IDPs are biopolymers with a broad configuration state space and their actual conformation depends on non-covalent interactions of its amino acid side chain groups ...
Source: European Biophysics Journal : EBJ - October 13, 2023 Category: Physics Authors: Micha ł K Białobrzewski Barbara P Klepka Agnieszka Micha ś Maja K Cieplak-Rotowska Zuzanna Stasza łek Anna Nied źwiecka Source Type: research
Diversity of hydrodynamic radii of intrinsically disordered proteins
Eur Biophys J. 2023 Oct 13. doi: 10.1007/s00249-023-01683-8. Online ahead of print.ABSTRACTIntrinsically disordered proteins (IDPs) form an important class of biomolecules regulating biological processes in higher organisms. The lack of a fixed spatial structure facilitates them to perform their regulatory functions and allows the efficiency of biochemical reactions to be controlled by temperature and the cellular environment. From the biophysical point of view, IDPs are biopolymers with a broad configuration state space and their actual conformation depends on non-covalent interactions of its amino acid side chain groups ...
Source: European Biophysics Journal : EBJ - October 13, 2023 Category: Physics Authors: Micha ł K Białobrzewski Barbara P Klepka Agnieszka Micha ś Maja K Cieplak-Rotowska Zuzanna Stasza łek Anna Nied źwiecka Source Type: research
Diversity of hydrodynamic radii of intrinsically disordered proteins
Eur Biophys J. 2023 Oct 13. doi: 10.1007/s00249-023-01683-8. Online ahead of print.ABSTRACTIntrinsically disordered proteins (IDPs) form an important class of biomolecules regulating biological processes in higher organisms. The lack of a fixed spatial structure facilitates them to perform their regulatory functions and allows the efficiency of biochemical reactions to be controlled by temperature and the cellular environment. From the biophysical point of view, IDPs are biopolymers with a broad configuration state space and their actual conformation depends on non-covalent interactions of its amino acid side chain groups ...
Source: European Biophysics Journal : EBJ - October 13, 2023 Category: Physics Authors: Micha ł K Białobrzewski Barbara P Klepka Agnieszka Micha ś Maja K Cieplak-Rotowska Zuzanna Stasza łek Anna Nied źwiecka Source Type: research
Diversity of hydrodynamic radii of intrinsically disordered proteins
Eur Biophys J. 2023 Oct 13. doi: 10.1007/s00249-023-01683-8. Online ahead of print.ABSTRACTIntrinsically disordered proteins (IDPs) form an important class of biomolecules regulating biological processes in higher organisms. The lack of a fixed spatial structure facilitates them to perform their regulatory functions and allows the efficiency of biochemical reactions to be controlled by temperature and the cellular environment. From the biophysical point of view, IDPs are biopolymers with a broad configuration state space and their actual conformation depends on non-covalent interactions of its amino acid side chain groups ...
Source: European Biophysics Journal : EBJ - October 13, 2023 Category: Physics Authors: Micha ł K Białobrzewski Barbara P Klepka Agnieszka Micha ś Maja K Cieplak-Rotowska Zuzanna Stasza łek Anna Nied źwiecka Source Type: research
Diversity of hydrodynamic radii of intrinsically disordered proteins
Eur Biophys J. 2023 Oct 13. doi: 10.1007/s00249-023-01683-8. Online ahead of print.ABSTRACTIntrinsically disordered proteins (IDPs) form an important class of biomolecules regulating biological processes in higher organisms. The lack of a fixed spatial structure facilitates them to perform their regulatory functions and allows the efficiency of biochemical reactions to be controlled by temperature and the cellular environment. From the biophysical point of view, IDPs are biopolymers with a broad configuration state space and their actual conformation depends on non-covalent interactions of its amino acid side chain groups ...
Source: European Biophysics Journal : EBJ - October 13, 2023 Category: Physics Authors: Micha ł K Białobrzewski Barbara P Klepka Agnieszka Micha ś Maja K Cieplak-Rotowska Zuzanna Stasza łek Anna Nied źwiecka Source Type: research
An intramolecular disulphide bond in human 4E-T affects its binding to eIF4E1a protein
Eur Biophys J. 2023 Oct 5. doi: 10.1007/s00249-023-01684-7. Online ahead of print.ABSTRACTThe cap at the 5'terminus of mRNA is a key determinant of gene expression in eukaryotic cells, which among others is required for cap dependent translation and protects mRNA from degradation. These properties of cap are mediated by several proteins. One of them is 4E-Transporter (4E-T), which plays an important role in translational repression, mRNA decay and P-bodies formation. 4E-T is also one of several proteins that interact with eukaryotic initiation factor 4E (eIF4E), a cap binding protein which is a key component of the transla...
Source: European Biophysics Journal : EBJ - October 5, 2023 Category: Physics Authors: Joanna Zuberek Marek Warzecha Mateusz Dobrowolski Anna Modrak-Wojcik Source Type: research
An intramolecular disulphide bond in human 4E-T affects its binding to eIF4E1a protein
Eur Biophys J. 2023 Oct 5. doi: 10.1007/s00249-023-01684-7. Online ahead of print.ABSTRACTThe cap at the 5'terminus of mRNA is a key determinant of gene expression in eukaryotic cells, which among others is required for cap dependent translation and protects mRNA from degradation. These properties of cap are mediated by several proteins. One of them is 4E-Transporter (4E-T), which plays an important role in translational repression, mRNA decay and P-bodies formation. 4E-T is also one of several proteins that interact with eukaryotic initiation factor 4E (eIF4E), a cap binding protein which is a key component of the transla...
Source: European Biophysics Journal : EBJ - October 5, 2023 Category: Physics Authors: Joanna Zuberek Marek Warzecha Mateusz Dobrowolski Anna Modrak-Wojcik Source Type: research
An intramolecular disulphide bond in human 4E-T affects its binding to eIF4E1a protein
Eur Biophys J. 2023 Oct 5. doi: 10.1007/s00249-023-01684-7. Online ahead of print.ABSTRACTThe cap at the 5'terminus of mRNA is a key determinant of gene expression in eukaryotic cells, which among others is required for cap dependent translation and protects mRNA from degradation. These properties of cap are mediated by several proteins. One of them is 4E-Transporter (4E-T), which plays an important role in translational repression, mRNA decay and P-bodies formation. 4E-T is also one of several proteins that interact with eukaryotic initiation factor 4E (eIF4E), a cap binding protein which is a key component of the transla...
Source: European Biophysics Journal : EBJ - October 5, 2023 Category: Physics Authors: Joanna Zuberek Marek Warzecha Mateusz Dobrowolski Anna Modrak-Wojcik Source Type: research
An intramolecular disulphide bond in human 4E-T affects its binding to eIF4E1a protein
Eur Biophys J. 2023 Oct 5. doi: 10.1007/s00249-023-01684-7. Online ahead of print.ABSTRACTThe cap at the 5'terminus of mRNA is a key determinant of gene expression in eukaryotic cells, which among others is required for cap dependent translation and protects mRNA from degradation. These properties of cap are mediated by several proteins. One of them is 4E-Transporter (4E-T), which plays an important role in translational repression, mRNA decay and P-bodies formation. 4E-T is also one of several proteins that interact with eukaryotic initiation factor 4E (eIF4E), a cap binding protein which is a key component of the transla...
Source: European Biophysics Journal : EBJ - October 5, 2023 Category: Physics Authors: Joanna Zuberek Marek Warzecha Mateusz Dobrowolski Anna Modrak-Wojcik Source Type: research
An intramolecular disulphide bond in human 4E-T affects its binding to eIF4E1a protein
Eur Biophys J. 2023 Oct 5. doi: 10.1007/s00249-023-01684-7. Online ahead of print.ABSTRACTThe cap at the 5'terminus of mRNA is a key determinant of gene expression in eukaryotic cells, which among others is required for cap dependent translation and protects mRNA from degradation. These properties of cap are mediated by several proteins. One of them is 4E-Transporter (4E-T), which plays an important role in translational repression, mRNA decay and P-bodies formation. 4E-T is also one of several proteins that interact with eukaryotic initiation factor 4E (eIF4E), a cap binding protein which is a key component of the transla...
Source: European Biophysics Journal : EBJ - October 5, 2023 Category: Physics Authors: Joanna Zuberek Marek Warzecha Mateusz Dobrowolski Anna Modrak-Wojcik Source Type: research
An intramolecular disulphide bond in human 4E-T affects its binding to eIF4E1a protein
Eur Biophys J. 2023 Oct 5. doi: 10.1007/s00249-023-01684-7. Online ahead of print.ABSTRACTThe cap at the 5'terminus of mRNA is a key determinant of gene expression in eukaryotic cells, which among others is required for cap dependent translation and protects mRNA from degradation. These properties of cap are mediated by several proteins. One of them is 4E-Transporter (4E-T), which plays an important role in translational repression, mRNA decay and P-bodies formation. 4E-T is also one of several proteins that interact with eukaryotic initiation factor 4E (eIF4E), a cap binding protein which is a key component of the transla...
Source: European Biophysics Journal : EBJ - October 5, 2023 Category: Physics Authors: Joanna Zuberek Marek Warzecha Mateusz Dobrowolski Anna Modrak-Wojcik Source Type: research
Relation between flexibility and intrinsically disorder regions in thermosensitive TRP channels reveal allosteric effects
Eur Biophys J. 2023 Sep 30. doi: 10.1007/s00249-023-01682-9. Online ahead of print.ABSTRACTHow a protein propagates the conformational changes throughout its structure remains largely unknown. In thermosensitive TRP channels, this allosteric communication is triggered by ligand interaction or in response to temperature changes. Because dynamic allostery suggests a dynamic role of disordered regions, in this work we set out to thoroughly evaluate these regions in six thermosensitive TRP channels. Thus, by contrasting the intrinsic flexibility of the transmembrane region as a function of the degree of disorder in those prote...
Source: European Biophysics Journal : EBJ - September 30, 2023 Category: Physics Authors: Garc ía-Morales Abigail Pulido Nancy O Balleza Daniel Source Type: research
Relation between flexibility and intrinsically disorder regions in thermosensitive TRP channels reveal allosteric effects
Eur Biophys J. 2023 Sep 30. doi: 10.1007/s00249-023-01682-9. Online ahead of print.ABSTRACTHow a protein propagates the conformational changes throughout its structure remains largely unknown. In thermosensitive TRP channels, this allosteric communication is triggered by ligand interaction or in response to temperature changes. Because dynamic allostery suggests a dynamic role of disordered regions, in this work we set out to thoroughly evaluate these regions in six thermosensitive TRP channels. Thus, by contrasting the intrinsic flexibility of the transmembrane region as a function of the degree of disorder in those prote...
Source: European Biophysics Journal : EBJ - September 30, 2023 Category: Physics Authors: Garc ía-Morales Abigail Pulido Nancy O Balleza Daniel Source Type: research
Relation between flexibility and intrinsically disorder regions in thermosensitive TRP channels reveal allosteric effects
Eur Biophys J. 2023 Sep 30. doi: 10.1007/s00249-023-01682-9. Online ahead of print.ABSTRACTHow a protein propagates the conformational changes throughout its structure remains largely unknown. In thermosensitive TRP channels, this allosteric communication is triggered by ligand interaction or in response to temperature changes. Because dynamic allostery suggests a dynamic role of disordered regions, in this work we set out to thoroughly evaluate these regions in six thermosensitive TRP channels. Thus, by contrasting the intrinsic flexibility of the transmembrane region as a function of the degree of disorder in those prote...
Source: European Biophysics Journal : EBJ - September 30, 2023 Category: Physics Authors: Garc ía-Morales Abigail Pulido Nancy O Balleza Daniel Source Type: research
Relation between flexibility and intrinsically disorder regions in thermosensitive TRP channels reveal allosteric effects
Eur Biophys J. 2023 Sep 30. doi: 10.1007/s00249-023-01682-9. Online ahead of print.ABSTRACTHow a protein propagates the conformational changes throughout its structure remains largely unknown. In thermosensitive TRP channels, this allosteric communication is triggered by ligand interaction or in response to temperature changes. Because dynamic allostery suggests a dynamic role of disordered regions, in this work we set out to thoroughly evaluate these regions in six thermosensitive TRP channels. Thus, by contrasting the intrinsic flexibility of the transmembrane region as a function of the degree of disorder in those prote...
Source: European Biophysics Journal : EBJ - September 30, 2023 Category: Physics Authors: Garc ía-Morales Abigail Pulido Nancy O Balleza Daniel Source Type: research
