Estrogen promotes fetal skeletal muscle mitochondrial distribution and ATP synthase activity important for insulin sensitivity in offspring
ConclusionWe suggest that estrogen is essential for fetal skeletal muscle mitochondrial development and thus glucose homeostasis in adulthood. (Source: Endocrine)
Source: Endocrine - March 13, 2024 Category: Endocrinology Source Type: research
Is thyroid function associated with polycystic ovary syndrome? A bidirectional Mendelian randomization study
ConclusionAlthough the MR analysis didn ’t indicate genetic causal association between thyroid function and PCOS after Bonferroni correction. Further efforts are needed to interpret the potential causal relationship between thyroid function and PCOS in different age and BMI subgroup. (Source: Endocrine)
Source: Endocrine - March 12, 2024 Category: Endocrinology Source Type: research
Early onset type 2 diabetes mellitus: an update
AbstractThe incidence and prevalence of type 2 diabetes mellitus (T2DM) in young individuals (aged<40 years) have significantly increased in recent years, approximating two to threefold increase in the respective rates. Numerous risk factors including severe obesity, family history, ethnicity, maternal diabetes or gestational diabetes, and female sex contribute to a younger age of onset. In terms of pathogenesis, impaired insulin secretion is the key operating mechanism, alongside with ectopic adiposity-related insulin resistance. T2DM diagnosis in a young adult requires the exclusion of type 1 diabetes mellitus (T1DM),...
Source: Endocrine - March 12, 2024 Category: Endocrinology Source Type: research
Renal effects of GLP-1 receptor agonists and tirzepatide in individuals with type 2 diabetes: seeds of a promising future
ConclusionTirzepatide is likely to counteract most of the pathogenetic factors contributing to CKD in T2D, potentially representing a step forward in incretin-based therapy towards nephroprotection. Further evidence is needed to understand its role in renal hemodynamics, fibrosis, cell damage and atherosclerosis, as well as to conclusively show reduction of hard renal outcomes. (Source: Endocrine)
Source: Endocrine - March 12, 2024 Category: Endocrinology Source Type: research
Is thyroid function associated with polycystic ovary syndrome? A bidirectional Mendelian randomization study
ConclusionAlthough the MR analysis didn ’t indicate genetic causal association between thyroid function and PCOS after Bonferroni correction. Further efforts are needed to interpret the potential causal relationship between thyroid function and PCOS in different age and BMI subgroup. (Source: Endocrine)
Source: Endocrine - March 12, 2024 Category: Endocrinology Source Type: research
Early onset type 2 diabetes mellitus: an update
AbstractThe incidence and prevalence of type 2 diabetes mellitus (T2DM) in young individuals (aged<40 years) have significantly increased in recent years, approximating two to threefold increase in the respective rates. Numerous risk factors including severe obesity, family history, ethnicity, maternal diabetes or gestational diabetes, and female sex contribute to a younger age of onset. In terms of pathogenesis, impaired insulin secretion is the key operating mechanism, alongside with ectopic adiposity-related insulin resistance. T2DM diagnosis in a young adult requires the exclusion of type 1 diabetes mellitus (T1DM),...
Source: Endocrine - March 12, 2024 Category: Endocrinology Source Type: research
Renal effects of GLP-1 receptor agonists and tirzepatide in individuals with type 2 diabetes: seeds of a promising future
ConclusionTirzepatide is likely to counteract most of the pathogenetic factors contributing to CKD in T2D, potentially representing a step forward in incretin-based therapy towards nephroprotection. Further evidence is needed to understand its role in renal hemodynamics, fibrosis, cell damage and atherosclerosis, as well as to conclusively show reduction of hard renal outcomes. (Source: Endocrine)
Source: Endocrine - March 12, 2024 Category: Endocrinology Source Type: research
Shared genetic architecture between periodontal disease and type 2 diabetes: a large scale genome-wide cross-trait analysis
ConclusionOur research has revealed a genetic link between T2D, glycemic traits, and PER that is influenced by biological pleiotropy. Notably, some of these links are not related to BMI. Our research highlights an underlying link between patients with T2D and PER, regardless of their BMI. (Source: Endocrine)
Source: Endocrine - March 9, 2024 Category: Endocrinology Source Type: research
Determination of cortisol cut-off limits and steroid dynamics in the ACTH stimulation test: a comparative analysis using Roche Elecsys Cortisol II immunoassay and LC-MS/MS
ConclusionElecsysCort II has high analytical performance and yields significantly lower cortisol concentrations than prior polyclonal immunoassays. This clinically relevant difference underscores the necessity for revised cut-off limits for improved diagnostic precision. Suggested 30-minute cortisol cutoff limits are 411 nmol/L (LC-MS/MS) and 426 nmol/L (ElecsysCort II). Adrenocortical steroids increased upon ACTH stimulation, except for cortisone in both sexes and testosterone in men, both of which decreased. (Source: Endocrine)
Source: Endocrine - March 9, 2024 Category: Endocrinology Source Type: research
Long-term complications of permanent hypoparathyroidism in adults: prevalence and associated factors
ConclusionOur results revealed high prevalences of neurological, ocular, and renal complications in patients with CHPT and emphasized the importance of regular biological monitoring, therapeutic adjustments, screening, and adherence to treatment in the prevention of these complications. (Source: Endocrine)
Source: Endocrine - March 9, 2024 Category: Endocrinology Source Type: research
Shared genetic architecture between periodontal disease and type 2 diabetes: a large scale genome-wide cross-trait analysis
ConclusionOur research has revealed a genetic link between T2D, glycemic traits, and PER that is influenced by biological pleiotropy. Notably, some of these links are not related to BMI. Our research highlights an underlying link between patients with T2D and PER, regardless of their BMI. (Source: Endocrine)
Source: Endocrine - March 9, 2024 Category: Endocrinology Source Type: research
Determination of cortisol cut-off limits and steroid dynamics in the ACTH stimulation test: a comparative analysis using Roche Elecsys Cortisol II immunoassay and LC-MS/MS
ConclusionElecsysCort II has high analytical performance and yields significantly lower cortisol concentrations than prior polyclonal immunoassays. This clinically relevant difference underscores the necessity for revised cut-off limits for improved diagnostic precision. Suggested 30-minute cortisol cutoff limits are 411 nmol/L (LC-MS/MS) and 426 nmol/L (ElecsysCort II). Adrenocortical steroids increased upon ACTH stimulation, except for cortisone in both sexes and testosterone in men, both of which decreased. (Source: Endocrine)
Source: Endocrine - March 9, 2024 Category: Endocrinology Source Type: research
Long-term complications of permanent hypoparathyroidism in adults: prevalence and associated factors
ConclusionOur results revealed high prevalences of neurological, ocular, and renal complications in patients with CHPT and emphasized the importance of regular biological monitoring, therapeutic adjustments, screening, and adherence to treatment in the prevention of these complications. (Source: Endocrine)
Source: Endocrine - March 9, 2024 Category: Endocrinology Source Type: research
