LncRNA GAS8-AS1 dinucleotide genetic variantn.713A & gt;G, n.714T & gt;C is associated with early-stage disease, lymph node, and distant metastasis in differentiated thyroid cancer
ConclusionsThese findings indicate thatGAS8-AS1 is genetically deregulated and implicated in several stages of DTC tumorigenesis suggesting it could be a promising prognostic biomarker in DTCs. (Source: Endocrine)
Source: Endocrine - April 5, 2024 Category: Endocrinology Source Type: research
Long-term use of clomiphene in male macroprolactinomas with persistent hypogonadism
ConclusionCC should be seen as a safe treatment option for men with macroprolactinoma and persistent hypogonadism. (Source: Endocrine)
Source: Endocrine - April 5, 2024 Category: Endocrinology Source Type: research
Quality of life in patients with hypoparathyroidism receiving standard treatment: an updated systematic review
ConclusionPatients with hypoparathyroidism receiving standard treatment report impairments in quality of life. The reasons for these impairments are probably multifaceted, making regular monitoring and the inclusion of various professionals necessary. (Source: Endocrine)
Source: Endocrine - April 5, 2024 Category: Endocrinology Source Type: research
An unusual brain lesion in a patient with Laron Syndrome
(Source: Endocrine)
Source: Endocrine - April 5, 2024 Category: Endocrinology Source Type: research
Deep learning-based computer-aided diagnosis system for the automatic detection and classification of lateral cervical lymph nodes on original ultrasound images of papillary thyroid carcinoma: a prospective diagnostic study
ConclusionsThis study developed a Deformable DETR model-based CAD system for automatically detecting and classifying lateral cervical LNs on original ultrasound images, which showed excellent diagnostic efficacy and clinical utility. It can be an important tool for assisting sonographers in the diagnosis process. (Source: Endocrine)
Source: Endocrine - April 3, 2024 Category: Endocrinology Source Type: research
NIFTP-adjusted risk estimation of Bethesda thyroid cytology categories should consider the indication for FNA according to TIRADS
ConclusionNIFTPs have heterogeneous presentation according to TIRADSs with very low indication rate for FNA. (Source: Endocrine)
Source: Endocrine - April 3, 2024 Category: Endocrinology Source Type: research
Feasibility of primary aldosteronism diagnosis in initial evaluation without medication withdrawal or confirmatory tests
ConclusionsARR during I-RAAS therapy demonstrates reliability and accuracy for PA diagnosis. An ARR > 50 combined with hypokalemia while on I-RAAS medication could be considered indicative of PA diagnosis. (Source: Endocrine)
Source: Endocrine - April 3, 2024 Category: Endocrinology Source Type: research
Disease-free survival and the prognostic factors affecting disease-free survival in patients with medullary thyroid carcinoma: a multicenter cohort study
ConclusionsThe absence of an excellent response after initial therapy is the strongest predictor of a worse DFS. However, a significant proportion of patients who achieve an excellent response could experience a structural recurrence. Therefore, careful follow-up of patients, including those achieving an excellent response is essential. (Source: Endocrine)
Source: Endocrine - April 3, 2024 Category: Endocrinology Source Type: research
Deep learning-based computer-aided diagnosis system for the automatic detection and classification of lateral cervical lymph nodes on original ultrasound images of papillary thyroid carcinoma: a prospective diagnostic study
ConclusionsThis study developed a Deformable DETR model-based CAD system for automatically detecting and classifying lateral cervical LNs on original ultrasound images, which showed excellent diagnostic efficacy and clinical utility. It can be an important tool for assisting sonographers in the diagnosis process. (Source: Endocrine)
Source: Endocrine - April 3, 2024 Category: Endocrinology Source Type: research
NIFTP-adjusted risk estimation of Bethesda thyroid cytology categories should consider the indication for FNA according to TIRADS
ConclusionNIFTPs have heterogeneous presentation according to TIRADSs with very low indication rate for FNA. (Source: Endocrine)
Source: Endocrine - April 3, 2024 Category: Endocrinology Source Type: research
Feasibility of primary aldosteronism diagnosis in initial evaluation without medication withdrawal or confirmatory tests
ConclusionsARR during I-RAAS therapy demonstrates reliability and accuracy for PA diagnosis. An ARR > 50 combined with hypokalemia while on I-RAAS medication could be considered indicative of PA diagnosis. (Source: Endocrine)
Source: Endocrine - April 3, 2024 Category: Endocrinology Source Type: research
Disease-free survival and the prognostic factors affecting disease-free survival in patients with medullary thyroid carcinoma: a multicenter cohort study
ConclusionsThe absence of an excellent response after initial therapy is the strongest predictor of a worse DFS. However, a significant proportion of patients who achieve an excellent response could experience a structural recurrence. Therefore, careful follow-up of patients, including those achieving an excellent response is essential. (Source: Endocrine)
Source: Endocrine - April 3, 2024 Category: Endocrinology Source Type: research
Association between educational attainment and thyroid cancer: evidence from a univariable and multivariable Mendelian randomization study
ConclusionThis MR study provided genetic evidence that longer education attainment is related to a lower risk of thyroid cancer. Strategies of expanding education may reduce the burden of thyroid cancer in the world. (Source: Endocrine)
Source: Endocrine - April 2, 2024 Category: Endocrinology Source Type: research
Role of bisphosphonates in hypertrophic osteoarthropathy: a systematic review
ConclusionBisphosphonates provide an effective and safe treatment option for primary and secondary HPOA. However, there is a lack of randomized controlled trials. (Source: Endocrine)
Source: Endocrine - April 2, 2024 Category: Endocrinology Source Type: research
Targeting DUSP5 suppresses malignant phenotypes of BRAF-mutant thyroid cancer cells and improves their response to sorafenib
ConclusionsOur data demonstrate an oncogenic role ofDUSP5 in BRAF-mutant thyroid cancer cells, and combined analysis of its expression andBRAFV600E mutation can accurately diagnose thyroid cancer. In addition, inhibition of DUSP5 improves the response of BRAF-mutant thyroid cancer cells to sorafenib. (Source: Endocrine)
Source: Endocrine - April 2, 2024 Category: Endocrinology Source Type: research
