Epidemiology of growth hormone deficiency in children and adolescents: a systematic review
ConclusionsThe included studies are mostly European, so the provided estimates cannot be considered global. International multicentre studies are needed to compare epidemiological estimates of GHD among different ethnical groups. Considering the considerable cost of human recombinant GH, the only available therapy to treat GHD, understanding accurate epidemiological estimates of GHD in each country is fundamental for resource allocation. (Source: Endocrine)
Source: Endocrine - March 18, 2024 Category: Endocrinology Source Type: research
Radioiodine whole body scan pitfalls in differentiated thyroid cancer
ConclusionsWBS is useful in the follow-up of patients with differentiated thyroid carcinoma, however it can be falsely positive in various circumstances. For this reason, it is critically important to correlate the scintigraphic result with patient ’s medical history, serum thyroglobulin levels, additional imaging studies and cytologic and/or histologic result. (Source: Endocrine)
Source: Endocrine - March 18, 2024 Category: Endocrinology Source Type: research
Somatostatin receptor imaging of thyroid tissue and differentiated thyroid cancer using gallium-68-labeled radiotracers —a review of clinical studies
ConclusionAlthough study variations exist, Ga-based somatostatin receptor imaging holds potential as a complementary tool alongside diagnostic methods in thyroid cancer diagnosis, with particular relevance to RAI-R DTC. In carefully selected patients demonstrating the presence of Ga-68 DOTATATE avid lesions, further exploration, and investigation into the potential utilization of Lu177 DOTATATE are warranted. (Source: Endocrine)
Source: Endocrine - March 18, 2024 Category: Endocrinology Source Type: research
Early age at menarche and the risk of gestational diabetes mellitus: a cohort study
ConclusionEarly AAM may be associated with an increased risk of GDM. Therefore, it can be used to identify high-risk women and implement preconception interventions for GDM prevention. Future studies should be conducted to confirm these findings. (Source: Endocrine)
Source: Endocrine - March 18, 2024 Category: Endocrinology Source Type: research
Epidemiology of growth hormone deficiency in children and adolescents: a systematic review
ConclusionsThe included studies are mostly European, so the provided estimates cannot be considered global. International multicentre studies are needed to compare epidemiological estimates of GHD among different ethnical groups. Considering the considerable cost of human recombinant GH, the only available therapy to treat GHD, understanding accurate epidemiological estimates of GHD in each country is fundamental for resource allocation. (Source: Endocrine)
Source: Endocrine - March 18, 2024 Category: Endocrinology Source Type: research
Radioiodine whole body scan pitfalls in differentiated thyroid cancer
ConclusionsWBS is useful in the follow-up of patients with differentiated thyroid carcinoma, however it can be falsely positive in various circumstances. For this reason, it is critically important to correlate the scintigraphic result with patient ’s medical history, serum thyroglobulin levels, additional imaging studies and cytologic and/or histologic result. (Source: Endocrine)
Source: Endocrine - March 18, 2024 Category: Endocrinology Source Type: research
Somatostatin receptor imaging of thyroid tissue and differentiated thyroid cancer using gallium-68-labeled radiotracers —a review of clinical studies
ConclusionAlthough study variations exist, Ga-based somatostatin receptor imaging holds potential as a complementary tool alongside diagnostic methods in thyroid cancer diagnosis, with particular relevance to RAI-R DTC. In carefully selected patients demonstrating the presence of Ga-68 DOTATATE avid lesions, further exploration, and investigation into the potential utilization of Lu177 DOTATATE are warranted. (Source: Endocrine)
Source: Endocrine - March 18, 2024 Category: Endocrinology Source Type: research
Early age at menarche and the risk of gestational diabetes mellitus: a cohort study
ConclusionEarly AAM may be associated with an increased risk of GDM. Therefore, it can be used to identify high-risk women and implement preconception interventions for GDM prevention. Future studies should be conducted to confirm these findings. (Source: Endocrine)
Source: Endocrine - March 18, 2024 Category: Endocrinology Source Type: research
Effect of post-transplant diabetes mellitus on cardiovascular events and mortality: a single ‐center retrospective cohort study
ConclusionsPTDM had no impact on patient survival. Hepatitis C seropositivity and recipient age at transplant predicted cardiovascular events in PTDM patients. (Source: Endocrine)
Source: Endocrine - March 15, 2024 Category: Endocrinology Source Type: research
Biochemical characteristics and clinical manifestation of normocalcemic primary hyperparathyroidism
ConclusionThe patients with nPHPT show a more favorable biochemical profile compared to those with hPHPT. Nevertheless, clinical manifestations and complications are similar, without a significant difference in the frequency of osteoporosis, nephrolithiasis, gastrointestinal disorders and low-energy fractures. (Source: Endocrine)
Source: Endocrine - March 15, 2024 Category: Endocrinology Source Type: research
Assessment of ChatGPT ’s adherence to ETA-thyroid nodule management guideline over two different time intervals 14 days apart: in binary and multiple-choice queries
ConclusionChatGPT exhibited improving potential as a clinical support tool in thyroid nodule management altgouh it showed varied performance for binary and multiple-choice questions.Clinical trial registrationN/A (Source: Endocrine)
Source: Endocrine - March 15, 2024 Category: Endocrinology Source Type: research
Effect of post-transplant diabetes mellitus on cardiovascular events and mortality: a single ‐center retrospective cohort study
ConclusionsPTDM had no impact on patient survival. Hepatitis C seropositivity and recipient age at transplant predicted cardiovascular events in PTDM patients. (Source: Endocrine)
Source: Endocrine - March 15, 2024 Category: Endocrinology Source Type: research
Biochemical characteristics and clinical manifestation of normocalcemic primary hyperparathyroidism
ConclusionThe patients with nPHPT show a more favorable biochemical profile compared to those with hPHPT. Nevertheless, clinical manifestations and complications are similar, without a significant difference in the frequency of osteoporosis, nephrolithiasis, gastrointestinal disorders and low-energy fractures. (Source: Endocrine)
Source: Endocrine - March 15, 2024 Category: Endocrinology Source Type: research
Assessment of ChatGPT ’s adherence to ETA-thyroid nodule management guideline over two different time intervals 14 days apart: in binary and multiple-choice queries
ConclusionChatGPT exhibited improving potential as a clinical support tool in thyroid nodule management altgouh it showed varied performance for binary and multiple-choice questions.Clinical trial registrationN/A (Source: Endocrine)
Source: Endocrine - March 15, 2024 Category: Endocrinology Source Type: research
Deficiency of protein C or protein S as a possible cause of osteoporosis
AbstractProteins C and S are vitamin K-dependent anticoagulative factors that also exert a significant influence on bone quality. Clinical studies have linked the deficiency of proteins C and S to lower bone mineral density and the onset of femoral head osteonecrosis in children. Rare foundational studies analyzing this topic have demonstrated that activated protein C, upon binding to the endothelial protein C receptor expressed on the surface of osteoblasts, promotes osteoblast proliferation. It is also established that proteins C and S play crucial roles in proper collagen synthesis and in maintaining the number of osteo...
Source: Endocrine - March 14, 2024 Category: Endocrinology Source Type: research
