Extra-adrenal aldosterone: a mini review focusing on the physiology and pathophysiology of intrarenal aldosterone
ConclusionsInhibition of intrarenal aldosterone signaling by aldosterone synthase inhibitors or mineralocorticoid receptor antagonists may be a hopeful pharmacological technique for the therapy of diabetic nephropathy and saltrelated hypertension. Yet, current reports are often conflicting or ambiguous, leading many to question whether extra-adrenal aldosterone exists, or whether it is of any physiological and pathophysiological significance. (Source: Endocrine)
Source: Endocrine - February 1, 2024 Category: Endocrinology Source Type: research
BEYOND 2 years: durability of metabolic benefits by simplification of complex insulin regimens in type 2 diabetes
ConclusionSimplification of complex insulin regimen may be a durable option in at least one-half of patients with type 2 diabetes.Clinical trial registrationClinical trial registration no. NCT04196231, clinicaltrials.gov. (Source: Endocrine)
Source: Endocrine - February 1, 2024 Category: Endocrinology Source Type: research
Is melatonin as an ergogenic hormone a myth? a systematic review and meta-analysis
ConclusionThe data indicate that melatonin is not an ergogenic hormone. In contrast, melatonin supplementation improves post-exercise recovery, even without altering its secretion. (Source: Endocrine)
Source: Endocrine - February 1, 2024 Category: Endocrinology Source Type: research
A role of NR4A2 in Graves ’ disease: regulation of Th17/Treg
ConclusionThese results indicate that the low level of NR4A2 in GD patients may suppress Treg differentiation, but have no influence on Th17 differentiation, leading to the imbalance of Th17/Treg and contributing to the development of GD. Revealing the role of NR4A2 in GD provides a novel insight for the treatment of GD. (Source: Endocrine)
Source: Endocrine - February 1, 2024 Category: Endocrinology Source Type: research
Thyroid transcription factor ‐1 expression in lung neuroendocrine tumours: a gender-related biomarker?
ConclusionsThis study highlights that TTF-1 positivity differs according to sex in lung NET, with a more common TTF-1 positive staining in female. Moreover, TTF-1 positivity correlated with the absence of necrosis. These data suggest that TTF-1 could potentially represent a gender-related biomarker for lung NET. (Source: Endocrine)
Source: Endocrine - February 1, 2024 Category: Endocrinology Source Type: research
