Dual-release hydrocortisone improves body composition and the glucometabolic profile in patients with secondary adrenal insufficiency
ConclusionThis study suggests that switching to DR-HC leads to lower late-evening cortisol/cortisone exposure and a more favourable metabolic profile and body composition. In contrast, decreased osteocalcin with increasing sclerostin might indicate a negative impact on bones.Clinical trial registrationEudraCT201400203932 (Source: Endocrine)
Source: Endocrine - February 12, 2024 Category: Endocrinology Source Type: research
Thyroid disorders induced by immune checkpoint inhibitors
AbstractImmune checkpoint inhibitors (ICIs) are a revolutionary class of drugs that powerfully contribute to cancer therapy by harnessing the immune system to fight malignancies. However, their successful use as anti-cancer drugs is accompanied by a wide spectrum of immune-related adverse effects (irAEs), including endocrinopathies. Among them, thyroid dysfunction stands out as one of the most common endocrinopathies induced by ICI therapy and surfaces as a prominent concern. Destructive thyroiditis is the pathophysiological basis shared by the most common patterns of thyrotoxicosis followed by hypothyroidism and isolated ...
Source: Endocrine - February 12, 2024 Category: Endocrinology Source Type: research
Impact of COVID-19 on testicular function: a systematic review and meta-analysis
ConclusionThe present systematic review and meta-analysis suggests the presence of an association between SARS-CoV-2 infection and primary testicular damage manifested with a picture of altered steroidogenesis and worsening spermatogenesis. The absence of the virus in the seminal fluid indicates a low possibility of sexual transmission of the infection to partners and offspring. However, our findings mostly show short-term follow-up, while few studies have considered the long-term consequences of the viral infection, thus further studies are needed to evaluate the long-term consequences on male reproductive health. (Source: Endocrine)
Source: Endocrine - February 12, 2024 Category: Endocrinology Source Type: research
The significance of an immunohistochemical marker-based panel in assisting the diagnosis of parathyroid carcinoma
ConclusionAn IHC panel of parafibromin, Ki-67 and E-cadherin may help to distinguish PC from parathyroid neoplasms. Among the 6 IHC markers and clinical features examined, the risk factor related to PC recurrence was parafibromin staining loss. (Source: Endocrine)
Source: Endocrine - February 10, 2024 Category: Endocrinology Source Type: research
Nodal metastasis in noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)
We present an adult male patient with a final histological diagnosis of NIFTP and lymph node metastasis noted at post-therapy whole-body scintigraphy performed some days after radioiodine therapy. (Source: Endocrine)
Source: Endocrine - February 10, 2024 Category: Endocrinology Source Type: research
The significance of an immunohistochemical marker-based panel in assisting the diagnosis of parathyroid carcinoma
ConclusionAn IHC panel of parafibromin, Ki-67 and E-cadherin may help to distinguish PC from parathyroid neoplasms. Among the 6 IHC markers and clinical features examined, the risk factor related to PC recurrence was parafibromin staining loss. (Source: Endocrine)
Source: Endocrine - February 10, 2024 Category: Endocrinology Source Type: research
Nodal metastasis in noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)
We present an adult male patient with a final histological diagnosis of NIFTP and lymph node metastasis noted at post-therapy whole-body scintigraphy performed some days after radioiodine therapy. (Source: Endocrine)
Source: Endocrine - February 10, 2024 Category: Endocrinology Source Type: research
Predictors of bone mineral density in patients receiving glucocorticoid replacement for Addison ’s disease
ConclusionStandard HC substitution does not considerably accelerate BMD loss in AD patients and their serum BTMs: CTX, osteocalcin, sclerostin, DKK-1, and ALP activity remain within the reference ranges. Independent predictors of low lumbar spine BMD, especially ALP activity, serum CTX and sclerostin, might be monitored during GC substitution. (Source: Endocrine)
Source: Endocrine - February 9, 2024 Category: Endocrinology Source Type: research
A rare case report of reversible glucose counterregulation in an insulinoma patient with type 2 diabetes
ConclusionsThe diagnosis of T2DM in the patient after surgery may be related to increased food intake and insulin resistance induced by hyperinsulinemia caused by long-term hypoglycemia. The reversible decrease in cortisol levels, not adrenocortical insufficiency during the diagnostic process, may be caused by a transient abnormality in glucose counterregulation. (Source: Endocrine)
Source: Endocrine - February 9, 2024 Category: Endocrinology Source Type: research
Predictors of bone mineral density in patients receiving glucocorticoid replacement for Addison ’s disease
ConclusionStandard HC substitution does not considerably accelerate BMD loss in AD patients and their serum BTMs: CTX, osteocalcin, sclerostin, DKK-1, and ALP activity remain within the reference ranges. Independent predictors of low lumbar spine BMD, especially ALP activity, serum CTX and sclerostin, might be monitored during GC substitution. (Source: Endocrine)
Source: Endocrine - February 9, 2024 Category: Endocrinology Source Type: research
A rare case report of reversible glucose counterregulation in an insulinoma patient with type 2 diabetes
ConclusionsThe diagnosis of T2DM in the patient after surgery may be related to increased food intake and insulin resistance induced by hyperinsulinemia caused by long-term hypoglycemia. The reversible decrease in cortisol levels, not adrenocortical insufficiency during the diagnostic process, may be caused by a transient abnormality in glucose counterregulation. (Source: Endocrine)
Source: Endocrine - February 9, 2024 Category: Endocrinology Source Type: research
Predictors of amputation in patients with diabetic foot ulcers: a multi-centre retrospective cohort study
ConclusionOur findings underscore Blood type-B, Hx. Of amputation, Bacterial culture-positive, Wagner 3 –5, and PAD as independent risk factors for amputation in DFU patients. The resultant nomogram exhibits substantial accuracy in predicting amputation occurrence. Timely identification of these risk factors can reduce DFU-related amputation rates. (Source: Endocrine)
Source: Endocrine - February 8, 2024 Category: Endocrinology Source Type: research
Comment on Guo et al. “Fat-free mass index is a feasible predictor of insulin resistance in women with polycystic ovary syndrome: evidence from a cross-sectional study”
(Source: Endocrine)
Source: Endocrine - February 8, 2024 Category: Endocrinology Source Type: research
Predictors of amputation in patients with diabetic foot ulcers: a multi-centre retrospective cohort study
ConclusionOur findings underscore Blood type-B, Hx. Of amputation, Bacterial culture-positive, Wagner 3 –5, and PAD as independent risk factors for amputation in DFU patients. The resultant nomogram exhibits substantial accuracy in predicting amputation occurrence. Timely identification of these risk factors can reduce DFU-related amputation rates. (Source: Endocrine)
Source: Endocrine - February 8, 2024 Category: Endocrinology Source Type: research
Comment on Guo et al. “Fat-free mass index is a feasible predictor of insulin resistance in women with polycystic ovary syndrome: evidence from a cross-sectional study”
(Source: Endocrine)
Source: Endocrine - February 8, 2024 Category: Endocrinology Source Type: research
