Role of bisphosphonates in hypertrophic osteoarthropathy: a systematic review
ConclusionBisphosphonates provide an effective and safe treatment option for primary and secondary HPOA. However, there is a lack of randomized controlled trials. (Source: Endocrine)
Source: Endocrine - April 2, 2024 Category: Endocrinology Source Type: research
Targeting DUSP5 suppresses malignant phenotypes of BRAF-mutant thyroid cancer cells and improves their response to sorafenib
ConclusionsOur data demonstrate an oncogenic role ofDUSP5 in BRAF-mutant thyroid cancer cells, and combined analysis of its expression andBRAFV600E mutation can accurately diagnose thyroid cancer. In addition, inhibition of DUSP5 improves the response of BRAF-mutant thyroid cancer cells to sorafenib. (Source: Endocrine)
Source: Endocrine - April 2, 2024 Category: Endocrinology Source Type: research
Association between educational attainment and thyroid cancer: evidence from a univariable and multivariable Mendelian randomization study
ConclusionThis MR study provided genetic evidence that longer education attainment is related to a lower risk of thyroid cancer. Strategies of expanding education may reduce the burden of thyroid cancer in the world. (Source: Endocrine)
Source: Endocrine - April 2, 2024 Category: Endocrinology Source Type: research
Role of bisphosphonates in hypertrophic osteoarthropathy: a systematic review
ConclusionBisphosphonates provide an effective and safe treatment option for primary and secondary HPOA. However, there is a lack of randomized controlled trials. (Source: Endocrine)
Source: Endocrine - April 2, 2024 Category: Endocrinology Source Type: research
Targeting DUSP5 suppresses malignant phenotypes of BRAF-mutant thyroid cancer cells and improves their response to sorafenib
ConclusionsOur data demonstrate an oncogenic role ofDUSP5 in BRAF-mutant thyroid cancer cells, and combined analysis of its expression andBRAFV600E mutation can accurately diagnose thyroid cancer. In addition, inhibition of DUSP5 improves the response of BRAF-mutant thyroid cancer cells to sorafenib. (Source: Endocrine)
Source: Endocrine - April 2, 2024 Category: Endocrinology Source Type: research
Lost in translation: evaluating the readability of online patient information for neuroendocrine tumors
ConclusionOur findings underscore the need to develop online patient education material that is readable and therefore easily understandable for patients and caregivers dealing with this unique group of malignancies. (Source: Endocrine)
Source: Endocrine - April 1, 2024 Category: Endocrinology Source Type: research
Effective TRIAC treatment of a THR β-mutated patient with thyroid hormone resistance
AbstractResistance to thyroid hormone (RTH) is a rare autosomal dominant disease characterized by an alteration of thyroid hormone negative feedback, usually as a consequence of a mutation in the thyroid hormone receptor-b gene (THR β). It is characterized by high variability of clinical manifestations, ranging from isolated abnormal thyroid function tests without symptoms to severe and impaired clinical conditions. Here we report the case of a woman who was diagnosed with RTH β when she was 35 years old and was treated with 3,5,3-triiodiothyroacetic acid (TRIAC) because of the onset of clinical symptoms of hyperthyroidi...
Source: Endocrine - April 1, 2024 Category: Endocrinology Source Type: research
Serum sex hormones correlate with pathological features of papillary thyroid cancer
ConclusionWe observed that serum sex hormones correlate with the pathological features of PTC in male patients, for the first time in a clinical study. High serum estrogens may be a risk factor for PTC, while androgens are the opposite. This somewhat corroborates previous research and provides new variables for future PTC prediction models. (Source: Endocrine)
Source: Endocrine - April 1, 2024 Category: Endocrinology Source Type: research
Efficacy of fecal microbiota transplantation in type 2 diabetes mellitus: a systematic review and meta-analysis
ConclusionIn patients with type 2 diabetes mellitus, FMT treatment can reduce the levels of PBG, TG, HOMA-IR, TC, ALT, and DBP, especially in the combined treatment regimen. In addition, FMT can reshape the intestinal flora and establish the balance of dominant flora. (Source: Endocrine)
Source: Endocrine - April 1, 2024 Category: Endocrinology Source Type: research
Clinical characteristics, densitometric parameters and outcomes of patients with atypical femoral fractures related to bisphosphonate treatment for osteoporosis
ConclusionAFF was characterised by usually long duration of bisphosphonate use, higher BMD and more acute neck-shaft angle. AFF did not confer significant impairment in mobility or mortality. Nonetheless, further research work is necessary to optimise bone health among patients who develop AFF. (Source: Endocrine)
Source: Endocrine - April 1, 2024 Category: Endocrinology Source Type: research
Changes in the outcomes of patients with anaplastic thyroid carcinoma over the past two decades
ConclusionsWhile anaplastic thyroid carcinoma remains a deadly cancer, survival seems to be improving for the last few years compared to earlier years. There is still additional work to be done to improve the outcomes of those patients. (Source: Endocrine)
Source: Endocrine - April 1, 2024 Category: Endocrinology Source Type: research
Lost in translation: evaluating the readability of online patient information for neuroendocrine tumors
ConclusionOur findings underscore the need to develop online patient education material that is readable and therefore easily understandable for patients and caregivers dealing with this unique group of malignancies. (Source: Endocrine)
Source: Endocrine - April 1, 2024 Category: Endocrinology Source Type: research
A prediction model based on random survival forest analysis of the overall survival of elderly female papillary thyroid carcinoma patients: a SEER-based study
ConclusionsThe RSF model we developed performed better than the Cox model and might be valuable for clinical practice. (Source: Endocrine)
Source: Endocrine - April 1, 2024 Category: Endocrinology Source Type: research
Effective TRIAC treatment of a THR β-mutated patient with thyroid hormone resistance
AbstractResistance to thyroid hormone (RTH) is a rare autosomal dominant disease characterized by an alteration of thyroid hormone negative feedback, usually as a consequence of a mutation in the thyroid hormone receptor-b gene (THR β). It is characterized by high variability of clinical manifestations, ranging from isolated abnormal thyroid function tests without symptoms to severe and impaired clinical conditions. Here we report the case of a woman who was diagnosed with RTH β when she was 35 years old and was treated with 3,5,3-triiodiothyroacetic acid (TRIAC) because of the onset of clinical symptoms of hyperthyroidi...
Source: Endocrine - April 1, 2024 Category: Endocrinology Source Type: research
Long-term effectiveness of zoledronic acid in patients with Paget ’s disease of bone – a retrospective cohort study
ConclusionThe majority of patients with PDB experience a mild disease course, marked by monostotic involvement and a low prevalence of fractures. Zoledronic acid effectively manages PDB, providing sustained biochemical response. The necessity for multiple zoledronic acid injections remains questionable, often implemented due to osteoporosis. (Source: Endocrine)
Source: Endocrine - March 30, 2024 Category: Endocrinology Source Type: research
