Artificial Intelligence-based quantitative evaluation of retinal vascular parameters in thyroid-associated ophthalmopathy
ConclusionsDue to its accessibility, affordability, and non-invasive nature, retinal vascular Df may serve as a surrogate marker for TAO and might be used to identify severe cases. With relatively high diagnostic performance, the Df is of some utility for the detection of TAO. (Source: Endocrine)
Source: Endocrine - February 3, 2024 Category: Endocrinology Source Type: research
The impact of thyroid function on total spine bone mineral density in postmenopausal women
ConclusionThe total spinal BMD had a positive relationship with thyroid stimulating hormone in postmenopausal women, and that appropriate TSH level (1.38 –2.32 mIU/L) was accompanied by higher total spinal BMD. (Source: Endocrine)
Source: Endocrine - February 3, 2024 Category: Endocrinology Source Type: research
Artificial Intelligence-based quantitative evaluation of retinal vascular parameters in thyroid-associated ophthalmopathy
ConclusionsDue to its accessibility, affordability, and non-invasive nature, retinal vascular Df may serve as a surrogate marker for TAO and might be used to identify severe cases. With relatively high diagnostic performance, the Df is of some utility for the detection of TAO. (Source: Endocrine)
Source: Endocrine - February 3, 2024 Category: Endocrinology Source Type: research
Examining the molecular mechanisms of topiramate in alleviating insulin resistance: A study on C2C12 myocytes and 3T3L-1 adipocytes
ConclusionThis study provides preliminary insights into the mechanisms through which topiramate modulates insulin resistance in C2C12 myocytes and 3T3L-1 adipocytes, enhancing our understanding of its therapeutic potential in managing weight and insulin sensitivity in migraine patients. (Source: Endocrine)
Source: Endocrine - February 3, 2024 Category: Endocrinology Source Type: research
The impact of thyroid function on total spine bone mineral density in postmenopausal women
ConclusionThe total spinal BMD had a positive relationship with thyroid stimulating hormone in postmenopausal women, and that appropriate TSH level (1.38 –2.32 mIU/L) was accompanied by higher total spinal BMD. (Source: Endocrine)
Source: Endocrine - February 3, 2024 Category: Endocrinology Source Type: research
Somatostatin receptor subtype 2A expression and genetics in 184 paragangliomas: a single center retrospective observational study
ConclusionsSSTR2A negativity was correlated with extra-adrenal tumor location and PVs in cluster 1B and cluster 2 genes such asVHL, FGFR1 andHRAS. Immunohistochemistry of SSTR2A should be taken into consideration in the personalized management of PGLs. (Source: Endocrine)
Source: Endocrine - February 2, 2024 Category: Endocrinology Source Type: research
Surgical outcome after thyroidectomy due to Graves ’ disease and Lugol iodine treatment: a retrospective register-based cohort study
ConclusionPatients in our cohort undergoing thyroidectomy due to Graves ’ disease pre-operatively treated with Lugol iodine as a rescue therapy had a higher risk of experiencing short term post-operative hypocalcemia. (Source: Endocrine)
Source: Endocrine - February 2, 2024 Category: Endocrinology Source Type: research
Somatostatin receptor subtype 2A expression and genetics in 184 paragangliomas: a single center retrospective observational study
ConclusionsSSTR2A negativity was correlated with extra-adrenal tumor location and PVs in cluster 1B and cluster 2 genes such asVHL, FGFR1 andHRAS. Immunohistochemistry of SSTR2A should be taken into consideration in the personalized management of PGLs. (Source: Endocrine)
Source: Endocrine - February 2, 2024 Category: Endocrinology Source Type: research
Surgical outcome after thyroidectomy due to Graves ’ disease and Lugol iodine treatment: a retrospective register-based cohort study
ConclusionPatients in our cohort undergoing thyroidectomy due to Graves ’ disease pre-operatively treated with Lugol iodine as a rescue therapy had a higher risk of experiencing short term post-operative hypocalcemia. (Source: Endocrine)
Source: Endocrine - February 2, 2024 Category: Endocrinology Source Type: research
Is melatonin as an ergogenic hormone a myth? a systematic review and meta-analysis
ConclusionThe data indicate that melatonin is not an ergogenic hormone. In contrast, melatonin supplementation improves post-exercise recovery, even without altering its secretion. (Source: Endocrine)
Source: Endocrine - February 1, 2024 Category: Endocrinology Source Type: research
A role of NR4A2 in Graves ’ disease: regulation of Th17/Treg
ConclusionThese results indicate that the low level of NR4A2 in GD patients may suppress Treg differentiation, but have no influence on Th17 differentiation, leading to the imbalance of Th17/Treg and contributing to the development of GD. Revealing the role of NR4A2 in GD provides a novel insight for the treatment of GD. (Source: Endocrine)
Source: Endocrine - February 1, 2024 Category: Endocrinology Source Type: research
Thyroid transcription factor ‐1 expression in lung neuroendocrine tumours: a gender-related biomarker?
ConclusionsThis study highlights that TTF-1 positivity differs according to sex in lung NET, with a more common TTF-1 positive staining in female. Moreover, TTF-1 positivity correlated with the absence of necrosis. These data suggest that TTF-1 could potentially represent a gender-related biomarker for lung NET. (Source: Endocrine)
Source: Endocrine - February 1, 2024 Category: Endocrinology Source Type: research
Use of vitamin D with anti-osteoporotic drugs: are available clinical trials telling us the whole story?
AbstractThere is a strong rationale for using vitamin D in combination with anti-osteoporotic drugs. Still, available trials do not give clear indications in this setting, presenting a suboptimal and heavily inhomogeneous experimental design. Health authorities should revise requirements for using vitamin D in anti-osteoporotic drug trials to maximise their effect and produce reliable indications for clinical practice in this setting. (Source: Endocrine)
Source: Endocrine - February 1, 2024 Category: Endocrinology Source Type: research
Surgical management of low-risk papillary thyroid cancer in real life in Spain: a nationwide survey of endocrine neck surgeons and endocrinologists
ConclusionThe real clinical practice of Spanish specialists is far from what is recommended by the clinical guidelines in patients with low-risk PTC, especially among high-volume professionals. (Source: Endocrine)
Source: Endocrine - February 1, 2024 Category: Endocrinology Source Type: research
The mystery of transient pregnancy-induced cushing ’s syndrome: a case report and literature review highlighting GNAS somatic mutations and LHCGR overexpression
ConclusionTransient pregnancy-induced Cushing ’s syndrome may be associated with somaticGNAS mutations and altered adrenal pathology due to abnormal activation of LHCGR. (Source: Endocrine)
Source: Endocrine - February 1, 2024 Category: Endocrinology Source Type: research
