Incidence and Clinicopathological Features of Differentiated High-Grade Thyroid Carcinomas: An Institutional Experience
This study confirmed that DHGTC is significantly associated with aggressive clinicopathological fea tures and poor clinical outcomes, similar to PDTC. Although the incidence is low, careful microscopic examination of HG features in DTC is required. (Source: Endocrine Pathology)
Source: Endocrine Pathology - July 29, 2023 Category: Pathology Source Type: research
Multilineage Pituitary Neuroendocrine Tumors (PitNETs) Expressing PIT1 and SF1
AbstractPitNETs are usually restricted in their cytodifferentiation to only one of 3 lineages dictated by expression of the pituitary transcription factors (TFs) PIT1, TPIT, or SF1. Tumors that show lineage infidelity and express multiple TFs are rare. We searched the pathology files of 4 institutions for PitNETs with coexpression of PIT1 and SF1. We identified 38 tumors in 21 women and 17 men, average age 53 (range 21 –79) years. They represented 1.3 to 2.5% of PitNETs at each center. Acromegaly was the presentation in 26 patients; 2 had central hyperthyroidism associated with growth hormone (GH) excess and one had sign...
Source: Endocrine Pathology - June 2, 2023 Category: Pathology Source Type: research
Gastric Amphicrine Carcinoma Showing Neuroendocrine and Pancreatic Acinar Cell Differentiation. Lesson from a Challenging Case Opening New Perspectives in the Diagnostic Work-Up of Gastric Neuroendocrine Neoplasms
AbstractAmphicrine carcinomas are epithelial neoplasms composed of cells with co-existing exocrine-neuroendocrine phenotype and are challenging lesions from both diagnostic and therapeutic perspectives.Here, we report the case of a 63-year-old male patient with a gastric nodule that was endoscopically biopsied, revealing histological features of a type 3 well-differentiated gastric neuroendocrine tumor (NET). At imaging, the lesion was single and limited to the stomach, but did not presentIn −111Octreotide uptake, despite SSTR2A immunohistochemical expression. The patient underwent a wedge resection of the gastric wall, ...
Source: Endocrine Pathology - May 30, 2023 Category: Pathology Source Type: research
Cribriform Morular Thyroid Carcinoma – Ultimobranchial Pouch-Related? Deep Molecular Insights of a Unique Case
Abstract
A 44-year-old female patient with a familial adenomatous polyposis (FAP) was diagnosed with a cribriform morular thyroid carcinoma (CMTC). We observed within the very necrotic tumor a small but distinct poorly differentiated carcinomatous component. As expected, next generation sequencing of both components revealed a homozygousAPC mutation and in addition, aTERT promoter mutation. ATP53 mutation was found exclusively in the CMTC part, while the poorly differentiated component showed a clonal evolution, harboring an activatingPIK3CA mutation and copy number gains ofBRCA2,FGF23,FGFR1, andPIK3CB—alterations whi...
Source: Endocrine Pathology - May 30, 2023 Category: Pathology Source Type: research
3rd Edition of Diagnostic Pathology: Endocrine by Vania Nos é
(Source: Endocrine Pathology)
Source: Endocrine Pathology - May 24, 2023 Category: Pathology Source Type: research
Progress in Adrenal Cortical Neoplasms: From Predictive Histomorphology to FLCN-Driven Germline Pathogenesis and the Prognostic Performance of Multiparameter Scoring Systems in Pediatric Adrenal Cortical Neoplasms
(Source: Endocrine Pathology)
Source: Endocrine Pathology - May 23, 2023 Category: Pathology Source Type: research
Inflammatory and Infectious Disorders in Endocrine Pathology
AbstractA variety of inflammatory conditions may directly involve the endocrine glands, leading to endocrine dysfunction that can cause severe consequences on patients ’ health, if left untreated. Inflammation of the endocrine system may be caused by either infectious agents or other mechanisms, including autoimmune and other immune-mediated processes. Not infrequently, inflammatory and infectious diseases may appear as tumor-like lesions of endocrine organs and simulate neoplastic processes. These diseases may be clinically under-recognized and not infrequently the diagnosis is suggested on pathological samples. Thus, t...
Source: Endocrine Pathology - May 20, 2023 Category: Pathology Source Type: research
Clinical and Pathological Features and Gene Expression Profiles of Clinically Aggressive Papillary Thyroid Carcinomas
In conclusion, our study revealed specific molecular signatures and morphological features in aggressive PTC that may be useful to predict more aggressive behavior in a subset of PTC patients. These findings may be useful when developing novel, tailored treatment options for these patients. (Source: Endocrine Pathology)
Source: Endocrine Pathology - May 19, 2023 Category: Pathology Source Type: research
High Grade Differentiated Follicular Cell-Derived Thyroid Carcinoma Versus Poorly Differentiated Thyroid Carcinoma: A Clinicopathologic Analysis of 41 Cases
AbstractCriteria overlap for separating between malignant follicular epithelial cell-derived thyroid gland neoplasms with high grade features of increased mitoses and tumor necrosis but lacking anaplastic histology. Patterns of growth, nuclear features, tumor necrosis, and various mitotic index cutoffs are suggested, but a reproducible Ki-67-based labeling index has not been established. Forty-one cases diagnosed as poorly differentiated thyroid carcinoma (PDTC) or high grade differentiated follicular cell-derived thyroid carcinoma (HGDFCDTC) were reviewed, with histologic features, mitotic figure counts, and Ki-67 labelin...
Source: Endocrine Pathology - May 17, 2023 Category: Pathology Source Type: research
The Driver Role of Pathologists in Endocrine Oncology: What Clinicians Seek in Pathology Reports
AbstractEndocrine neoplasia represents an increasingly broad spectrum of disorders. Endocrine neoplasms range from incidental findings to potentially lethal malignancies. In this paper, we cover the impact of pathology in the interpretation of the clinic-pathological, genetic, and radiographic features underpinning these neoplasms. We highlight the critical role of multidisciplinary interactions in structuring a rational diagnostic and efficient therapeutic plan and emphasize the role of histopathological input in decision-making. In this context, standardized pathology reporting and second opinion endocrine pathology revi...
Source: Endocrine Pathology - May 11, 2023 Category: Pathology Source Type: research
Pediatric Adrenocortical Neoplasms: A Study Comparing Three Histopathological Scoring Systems
AbstractAdrenocortical neoplasms are rare in childhood. Their histopathological categorization into benign and malignant is often challenging, impacting further management. While the AFIP/Wieneke scoring system is widely used for the prognostic classification of these tumors, it has limitations. Few other tumor scoring systems have evolved over the past few years. These have been validated in adults but not yet in pediatric patients. We evaluated a cohort of pediatric adrenocortical neoplasms to assess the applicability of AFIP/Wieneke criteria and the recently introduced Helsinki score and reticulin algorithm in predictin...
Source: Endocrine Pathology - May 9, 2023 Category: Pathology Source Type: research
Thyroid Nodules and Follicular Cell-Derived Thyroid Carcinomas in Children
AbstractAlthough pediatric thyroid tumors have many similarities to those occurring in adults, significant differences are also recognized. For example, although thyroid nodules in children are much less common than in adults, a higher percentage is malignant. Moreover, while pediatric papillary thyroid carcinoma (PTC) is associated with more advanced disease, death due to disease in children and adolescents is very rare, even when distant metastases are present. Some subtypes of thyroid carcinoma, like diffuse sclerosing variant, are especially common in children and adolescents. Moreover, certain histologic findings, suc...
Source: Endocrine Pathology - May 9, 2023 Category: Pathology Source Type: research
Mucinous Amphicrine Carcinoma of the Pancreas: A Diagnostic Pitfall
(Source: Endocrine Pathology)
Source: Endocrine Pathology - May 3, 2023 Category: Pathology Source Type: research
Typical “BRAFV600E-Like” Atypia in Papillary Thyroid Carcinoma: A Morphologic Sign of a Driver Mutation
(Source: Endocrine Pathology)
Source: Endocrine Pathology - April 21, 2023 Category: Pathology Source Type: research
The Unique Importance of Differentiation and Function in Endocrine Neoplasia
AbstractThe assessment of cell differentiation in endocrine neoplasms involves not only the identification of a cell ’s structure and expression of specific transcription factors which regulate that cell, but also the identification of hormones and/or enzymes involved in hormone synthesis. The importance of this functional characterization is emphasized by the fact that the hormones serve as biomarkers for clini cal surveillance to identify persistence, recurrence, or progression of disease. Sometimes, unusual patterns of hormone expression lead to unexpected clinical signs and symptoms. Loss of differentiated hormone pr...
Source: Endocrine Pathology - April 12, 2023 Category: Pathology Source Type: research
