The Significance of RAS-Like Mutations and MicroRNA Profiling in Predicting Malignancy in Thyroid Biopsy Specimens
This study aims to retrospectively evaluate institutional experience of Interpace (ThyGeNEXT® and ThyraMIR®; Pittsburgh, PA) testing and to determine the rate of malignancy in resected nodules, stratified by mutational analysis and microRNA profile. Of 1917 fine need aspirations, 140 (7.3%) underwent Interpace testing: 47 (33.6%) were molecular-not-benign (harbored mutation, fusion, and/or positive miRNA) and 93 (66.4%) were molecular-benign (no mutations or fusions and negative microRNA). Surgery was spared in 79.6% of molecular-benign and 61.4% of all tested patients. Fifty-four (38.6%) underwent resection. Seventeen (...
Source: Endocrine Pathology - October 13, 2022 Category: Pathology Source Type: research
Endocrine Pathology Society Hubert Wolfe Award for 2022: Call for Nominations
(Source: Endocrine Pathology)
Source: Endocrine Pathology - October 6, 2022 Category: Pathology Source Type: research
Thyroid Nodules with Indeterminate FNAC According to the Italian Classification System: Prevalence, Rate of Operation, and Impact on Risk of Malignancy. An Updated Systematic Review and Meta-analysis
This study aimed to achieve high-evidence estimates of the prevalence, rate of operation, and risk of malignancy of ITNs, including TIR3A and TIR3B ITNs. This systematic review was conducted according to MOOSE to retrieve all original studies citing ICCRTC. The last search was performed in February 2022. The risk of bias of the included studies was assessed. Separate proportion meta-analyses were performed with a random-effect model using OpenMeta[Analyst]. The online search processed 271 studies, and 33 were finally considered. First, the cancer prevalence among ITNs was 32.4%. Second, the cancer prevalence among TIR3As w...
Source: Endocrine Pathology - August 31, 2022 Category: Pathology Source Type: research
PHOX2B is a Sensitive and Specific Marker for the Histopathological Diagnosis of Pheochromocytoma and Paraganglioma
AbstractPheochromocytomas (PCCs) and paragangliomas (PGLs) are non-epithelial neuroendocrine neoplasms originating from the adrenal medulla and paraganglion of the sympathetic and parasympathetic nervous system, respectively. PCCs and PGLs show histological similarities with other epithelial neuroendocrine neoplasms and olfactory neuroblastomas (ONBs), and the differential diagnosis of PGLs is particularly difficult. Therefore, we compared the sensitivity of PHOX2A, PHOX2B, and tyrosine hydroxylase (TH) in the histopathological diagnosis of PCCs and PGLs immunohistochemically using the tissue microarrays of 297 neoplasms i...
Source: Endocrine Pathology - August 27, 2022 Category: Pathology Source Type: research
Medullary Thyroid Carcinoma in the IARC/WHO Neuroendocrine Schema
(Source: Endocrine Pathology)
Source: Endocrine Pathology - August 8, 2022 Category: Pathology Source Type: research
The Diagnostic Impact of Epigenomics in Pituicyte-derived Tumors: Report of an Unusual Sellar Lesion with Extensive Hemorrhage and Necrotic Debris
(Source: Endocrine Pathology)
Source: Endocrine Pathology - August 3, 2022 Category: Pathology Source Type: research
Metastatic Risk Stratification of 2526 Medullary Thyroid Carcinoma Patients: A Study Based on Surveillance, Epidemiology, and End Results Database
AbstractThe risk of distant metastasis in medullary thyroid carcinoma (MTC) has not been well studied. Additional evaluation of MTC metastatic risk can be helpful for improving the quality of medical management. Therefore, we conducted a large population study to develop a method to stratify the risk of metastasis at the initial presentation of MTC patients. We collected 3612 MTC patients from the Surveillance, Epidemiology, and End Results (SEER) database, and included 2526 MTC patients in the study after applying exclusion criteria. We selected the most informative variables from a learning cohort of 2019 patients to obt...
Source: Endocrine Pathology - July 19, 2022 Category: Pathology Source Type: research
Multifocal Fibrosing Thyroiditis: an Under-recognized Mimicker of Papillary Thyroid Carcinoma
AbstractMultifocal fibrosing thyroiditis (MFT) is an enigmatic entity, characterized by multiple fibrotic scar-like lesions with a paucicellular fibrotic center surrounded by a cellular peripheral area with reactive-appearing follicular cell atypia and variable chronic inflammation. Although poorly recognized and likely underreported in surgical pathology, the entity is considered rare with only 65 cases to date –including the current one reported to expand on the preoperative findings of this under-recognized entity. The average age of the patients is 46.8 years (range 15–71 years), 94% are female, with female to ma...
Source: Endocrine Pathology - July 11, 2022 Category: Pathology Source Type: research
Amphicrine Medullary Thyroid Carcinoma — a Case-Based Review Expanding on Its MUC Expression Profile
This report undertook a case-based review approach by discussing the cytological, histopathological, and ultrastructural features of this rare enigmatic entity, expanding on the radiological and novel MUC immunohistochemistry findings from a 28-year-old MEN2B syndrome patient with C cell hyperplasia and multifocal MTC with amphicrine features. The patient had widespread hematogenous metastases at presentation. MUC immunoexpression analysis revealed evidence of micro-lumina formation, and unique to-date unreported expression patterns of MUC1, MUC5AC, and MUC6 in an amphicrine subtype of MTC. Review of the literature identif...
Source: Endocrine Pathology - June 23, 2022 Category: Pathology Source Type: research
Immature PIT1-Lineage Pituitary Neuroendocrine Tumor: a 17-Year-Old Male with Pathogenic AIP Mutation
(Source: Endocrine Pathology)
Source: Endocrine Pathology - June 11, 2022 Category: Pathology Source Type: research
Molecular Subtypes of Extra-pulmonary Neuroendocrine Carcinomas Identified by the Expression of Neuroendocrine Lineage-Specific Transcription Factors
In conclusion, our results show that EPNEC possess distinct neuroendocrine-lineage-specific transcriptional profiles; moreover, lowINSM1 gene expression represents a novel potential unfavorable prognostic marker in high-grade NECs including those in extra-pulmonary location. (Source: Endocrine Pathology)
Source: Endocrine Pathology - May 24, 2022 Category: Pathology Source Type: research
Systematic Review and Meta-Analysis to Identify the Immunocytochemical Markers Effective in Delineating Benign from Malignant Thyroid Lesions in FNAC Samples
AbstractConventional cytology-based diagnosis for thyroid cancer is limited with more than 30 –45% of nodules categorized as indeterminate, necessitating surgery for confirming or refuting the diagnosis. This systematic review and meta-analysis were aimed at identifying immunocytochemical markers effective in delineating benign from malignant thyroid lesions in fine needle aspiration cytol ogy (FNAC) samples, thereby improving the accuracy of cytology diagnosis. A systematic review of relevant articles (2000–2021) from online databases was carried out and the search protocol registered in PROSPERO database (CRD42021229...
Source: Endocrine Pathology - May 21, 2022 Category: Pathology Source Type: research
External Validation of Three Available Grading Systems for Medullary Thyroid Carcinoma in a Single Institution Cohort
In conclusion, our results confirm the prognostic role of IMTCGS, supporting the importance of incorporating this information into the pathology report. However, none of the systems proved to predict the overall survival in this validation cohort. (Source: Endocrine Pathology)
Source: Endocrine Pathology - May 18, 2022 Category: Pathology Source Type: research
Ampullary Neuroendocrine Neoplasms: Identification of Prognostic Factors in a Multicentric Series of 119 Cases
In conclusion, we identified prognostic factors, which may eventually help guide treatment decisions in Amp-NENs. (Source: Endocrine Pathology)
Source: Endocrine Pathology - May 13, 2022 Category: Pathology Source Type: research
Grading of Medullary Thyroid Carcinoma: an Interobserver Reproducibility Study
AbstractGrade, based on proliferative activity and tumor necrosis, has recently been shown to be prognostic in medullary thyroid carcinoma (MTC) in multivariate analysis. The aim of this study was to evaluate the interobserver reproducibility of assessed grade in MTC. Three groups (each group included one resident/fellow and one attending pathologist) independently evaluated a cohort of 44 sporadic MTC. For each case, all available tumor slides were reviewed, and mitotic count and the presence of tumor necrosis were recorded. Ki-67 was performed, and the Ki-67 proliferative index was determined in the area of highest proli...
Source: Endocrine Pathology - May 13, 2022 Category: Pathology Source Type: research
