From Counting Mitoses to Ki67 Assessment: Technical Pitfalls in the New WHO Classification of Endocrine and Neuroendocrine Tumors
(Source: Endocrine Pathology)
Source: Endocrine Pathology - January 13, 2022 Category: Pathology Source Type: research

Thyroid Carcinoma with NSD3::NUTM1 Fusion: a Case with Thyrocyte Differentiation and Colloid Production
In this report, we present a high-grade thyroid carcinoma with anNSD3::NUTM1 fusion detected on expanded next-generation sequencing testing. Nuclear protein of the testis (NUT) carcinomas comprise high-grade, aggressive tumors characterized by rearrangements of theNUTM1 gene with various partner genes, most commonly the bromodomain protein genesBRD4 andBRD3. Approximately 10% of NUT carcinomas contain anNSD3::NUTM1 fusion. NUT carcinomas manifest as poorly differentiated or undifferentiated squamous carcinomas, and 33% show areas of mature squamous differentiation. Only exceptionally have NUT carcinomas shown histology dis...
Source: Endocrine Pathology - January 8, 2022 Category: Pathology Source Type: research

Alternative Lengthening of Telomeres (ALT) and Telomerase Reverse Transcriptase Promoter Methylation in Recurrent Adult and Primary Pediatric Pituitary Neuroendocrine Tumors
In conclusion, ALT is triggered at onset and maintained during tumor progression in a subset of adult PitNETs, suggesting that it could be used for clinical purposes, as a potential predictor of aggressive behavior. (Source: Endocrine Pathology)
Source: Endocrine Pathology - January 6, 2022 Category: Pathology Source Type: research

Correction to: Two Pituitary Neuroendocrine Tumors (PitNETs) with Very High Proliferation and TP53 Mutation  – High‑Grade PitNET or PitNEC?
(Source: Endocrine Pathology)
Source: Endocrine Pathology - December 21, 2021 Category: Pathology Source Type: research

Unexpected Widespread Bone Metastases from a BRAF K601N Mutated Follicular Thyroid Carcinoma within a Previously Resected Multinodular Goiter
AbstractFollicular thyroid carcinoma (FTC) represents the second most common malignant thyroid neoplasm after papillary carcinoma (PTC). FTC is characterized by the tendency to metastasize to distant sites such as bone and lung. In the last 20  years, the understanding of the molecular pathology of thyroid tumors has greatly improved. UncommonBRAF non-V600E mutations have been identified and are generally believed to associate with follicular patterned tumors of low malignant potential, particularly non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTPs) (i.e., non-invasive encapsulated foll...
Source: Endocrine Pathology - November 29, 2021 Category: Pathology Source Type: research

Immunohistochemical Expression of Choline Acetyltransferase and Catecholamine-Synthesizing Enzymes in Head-and-Neck and Thoracoabdominal Paragangliomas and Pheochromocytomas
AbstractParagangliomas (PGLs) are neural-crest-derived, non-epithelial neuroendocrine tumors distributed along the parasympathetic and sympathetic nerves. Head-and-neck PGLs (HNPGLs) have been recognized as nonchromaffin, nonfunctional, parasympathetic tumors. By contrast, thoracoabdominal paragangliomas and pheochromocytomas (PPGLs) are chromaffin, functional, sympathetic tumors. Although HNPGLs and PPGLs have the same histological structure, the zellballen pattern, composed of chief and sustentacular cells surrounded by abundant capillaries, the pathobiological differences between these types of PGLs remain unclarified. ...
Source: Endocrine Pathology - November 6, 2021 Category: Pathology Source Type: research

Recipient of the 2021 Endocrine Pathology Society Lifetime Achievement Award: Dr. Ronald A. DeLellis
(Source: Endocrine Pathology)
Source: Endocrine Pathology - November 1, 2021 Category: Pathology Source Type: research

Endocrine Pathology Society Hubert Wolfe Award for 2021: Call for Nominations
(Source: Endocrine Pathology)
Source: Endocrine Pathology - October 23, 2021 Category: Pathology Source Type: research

TERT Promoter Mutated Follicular Thyroid Carcinomas Exhibit a Distinct microRNA Expressional Profile with Potential Implications for Tumor Progression
(Source: Endocrine Pathology)
Source: Endocrine Pathology - October 21, 2021 Category: Pathology Source Type: research

Two Pituitary Neuroendocrine Tumors (PitNETs) with Very High Proliferation and TP53 Mutation — High-Grade PitNET or PitNEC?
This report expands the spectrum of pituitary neuroendocrine neo plasms. (Source: Endocrine Pathology)
Source: Endocrine Pathology - October 20, 2021 Category: Pathology Source Type: research