The 3rd Edition of Bethesda System for Reporting Thyroid Cytopathology: Highlights and Comments
(Source: Endocrine Pathology)
Source: Endocrine Pathology - November 30, 2023 Category: Pathology Source Type: research
Fundamentals of Endocrine Pathology: Part I
(Source: Endocrine Pathology)
Source: Endocrine Pathology - November 24, 2023 Category: Pathology Source Type: research
Obstacles to Tumor Capsule Assessment in Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP)
(Source: Endocrine Pathology)
Source: Endocrine Pathology - November 18, 2023 Category: Pathology Source Type: research
Endocrine Pathology Society Hubert Wolfe Award for 2023: Call for Nominations
(Source: Endocrine Pathology)
Source: Endocrine Pathology - November 18, 2023 Category: Pathology Source Type: research
A Critical Assessment of Diagnostic Criteria for the Tall Cell Subtype of Papillary Thyroid Carcinoma —How Much? How Tall? And When Is It Relevant?
AbstractTall cell papillary thyroid carcinoma (TC-PTC) is considered adverse histology. However, previous studies are confounded by inconsistent criteria and strong associations with other adverse features. It is therefore still unclear if TC-PTC represents an independent prognostic factor in multivariate analysis and, if it does, what criteria should be employed for the diagnosis. We retrospectively reviewed 487 PTCs from our institution (where we have historically avoided the prospective diagnosis of TC-PTC) for both the height of tall cells (that is if the cells were two, or three, times as tall as wide) and the percent...
Source: Endocrine Pathology - October 21, 2023 Category: Pathology Source Type: research
Neoplasms in Struma Ovarii: A Review
AbstractStruma ovarii is a well-known ovarian teratoma made up of benign thyroid tissue. These lesions demonstrate variable, normal architecture and normal thyroid immunohistochemical staining with positivity for TTF1, PAX8, and thyroglobulin. Though most are benign, some of these lesions can also present with a malignant component. Within this article, we review the most common diagnostic malignancies including papillary thyroid carcinoma, strumal carcinoid, highly differentiated follicular thyroid carcinoma, and other thyroid carcinomas. We additionally review the use of TTF1 staining to assist in differentiating these l...
Source: Endocrine Pathology - October 21, 2023 Category: Pathology Source Type: research
Glomangiosarcoma-like Anaplastic Transformation in Papillary Thyroid Carcinoma: A Novel Form of Heterologous Differentiation and a Systematic Review of Heterologous Element Prevalence
AbstractAnaplastic thyroid carcinoma (ATC) demonstrates a wide variety of morphologies and is characteristically associated with a differentiated thyroid carcinoma component. Heterologous differentiation is a rare, potentially challenging phenomenon in ATC, mostly observed as osteosarcomatous or chondrosarcomatous differentiation. We now describe a novel ‘glomangiosarcoma-like’ differentiation, review our archival experience from two institutions (UPMC, CC), and perform a systematic review for the prevalence of heterologous elements in ATC. The patient is a 57-year-old female who presented with 4.5 cm left thyroid, an...
Source: Endocrine Pathology - October 4, 2023 Category: Pathology Source Type: research
The Atlas of Non-neoplastic Disorders of the Endocrine System by Anthony J. Gill, Lori A. Erickson and Talia L. Fuchs, Series 5, Fascicle 13
(Source: Endocrine Pathology)
Source: Endocrine Pathology - September 11, 2023 Category: Pathology Source Type: research
Identification of NIFTP-Specific mRNA Markers for Reliable Molecular Diagnosis of Thyroid Tumors
This study is aimed at discovering NIFTP-specific mRNA markers through RNA sequencing analysis of thyroid tumor tissues. We performed mRNA expression profiling for 74 fresh frozen thyroid tissue samples, including NIFTP and benign and malignant follicular-cell-derived tumors. NIFTP/malignant tumors showed 255 downregulated genes and 737 upregulated genes compared to benign tumors. Venn diagram analysis revealed 19 significantly upregulated and 7 downregulated mRNAs in NIFTP. Akaike information criterion analysis allowed us to selectOCLN,ZNF423,LYG1, andAQP5 mRNA markers. We subsequently developed a predictive model based o...
Source: Endocrine Pathology - September 2, 2023 Category: Pathology Source Type: research
The Spectrum of Neuroendocrine Neoplasia: A Practical Approach to Diagnosis, Classification and Therapy by Sylvia L. Asa, Stefano La Rosa, Ozgur Mete
(Source: Endocrine Pathology)
Source: Endocrine Pathology - August 24, 2023 Category: Pathology Source Type: research
Well-Differentiated Neuroendocrine Tumor of the Gallbladder with Paraganglioma-Like Features: a Potential Mimicker of Gallbladder Paraganglioma
(Source: Endocrine Pathology)
Source: Endocrine Pathology - August 21, 2023 Category: Pathology Source Type: research
In Memory of Kalman Kovacs and Eva Horvath
(Source: Endocrine Pathology)
Source: Endocrine Pathology - August 15, 2023 Category: Pathology Source Type: research
DICER1 Mutations Do Not Always Indicate Dismal Prognosis in Pediatric Poorly Differentiated Thyroid Carcinomas
AbstractProgress in the field of pediatric thyroid pathology has linkedDICER1 mutations to benign follicular cell –derived thyroid tumors (e.g., follicular adenoma with papillary architecture, follicular nodular disease), low-risk follicular cell–derived differentiated thyroid carcinomas and PDTCs enriched in fatal or recurrent/progressive disease. The dismal outcome ofDICER1-harboring pediatric PDTCs stems from a limited number of reported patients ’ data given the rarity of pediatric PDTCs. In light of the former observations, the current study assessed clinicopathological variables of a series of 5 pediatric (≤â...
Source: Endocrine Pathology - August 14, 2023 Category: Pathology Source Type: research
A Combination of BRAF and EZH1/SPOP/ZNF148 Three-Gene Mutational Classifier Improves Benign Call Rate in Indeterminate Thyroid Nodules
AbstractReliable preoperative diagnosis of thyroid nodules remained challenging because of the inconclusiveness of fine-needle aspiration (FNA) cytology. In the present study, 583 formalin-fixed paraffin embedded (FFPE) thyroid nodule tissues and 161 FNA specimens were enrolled retrospectively. ThenBRAF V600E,EZH1 Q571R,SPOP P94R, andZNF148 mutations among these samples were identified using Sanger sequencing. Based on this four-gene genomic classifier, we proposed a two-step modality to diagnose thyroid nodules to differentiate benign and malignant thyroid nodules. In the FFPE group, thyroid cancers were effectively diagn...
Source: Endocrine Pathology - August 12, 2023 Category: Pathology Source Type: research
Immunoreactivity of HOXB13 in Neuroendocrine Neoplasms Is a Sensitive and Specific Marker of Rectal Well-Differentiated Neuroendocrine Tumors
AbstractHoxB13 is a transcription factor involved in defining of posterior endodermal derivatives, including prostate and rectum. While it is used as a marker of prostatic adenocarcinoma, it has not been studied systematically in neuroendocrine neoplasms. Thus, we performed HoxB13 immunohistochemistry in tissue microarrays and the whole sections of 232 neuroendocrine neoplasms. These included 34 paragangliomas (PGs), 20 cauda equina neuroendocrine tumors (CENETs), 123 well-differentiated neuroendocrine tumors (WDNETs), and 55 neuroendocrine carcinomas (NECs). WDNETs were additionally analyzed with SATB2, and colorectal WDN...
Source: Endocrine Pathology - August 8, 2023 Category: Pathology Source Type: research
