Did Introducing a New Category of Thyroid Tumors (Non-invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features) Decrease the Risk of Malignancy for the Diagnostic Categories in the Bethesda System for Reporting Thyroid Cytopathology?
AbstractIn 2016, Nikiforov et al. (JAMA Oncol 2:1023 –1029, 2016) proposed replacing the term “non-invasive encapsulated follicular variant of papillary thyroid carcinoma” (FVPTC) with the term “non-invasive follicular thyroid neoplasm with papillary-like nuclear features” (NIFTP). In 2018, to avoid the misdiagnosis of papillary thyroid canc er as NIFTP, the authors proposed changes to the criteria for NIFTP classification. Some previous studies evaluated the impact of NIFTP on the risk of malignancy (ROM) in the fine-needle aspiration cytology (FNAC) diagnostic categories according to the Bethesda System for Rep...
Source: Endocrine Pathology - March 30, 2020 Category: Pathology Source Type: research
Histopathologic Assessment of Capsular Invasion in Follicular Thyroid Neoplasms —an Observer Variation Study
In conclusion, this study revealed considerable interobserver variation in the evaluation of capsular invasion, especially in follicular neoplasms with questionable invasion. (Source: Endocrine Pathology)
Source: Endocrine Pathology - March 30, 2020 Category: Pathology Source Type: research
Thyroid Tumor Capsular Invasion: the Bottom Line or Much Ado About Nothing?
(Source: Endocrine Pathology)
Source: Endocrine Pathology - March 23, 2020 Category: Pathology Source Type: research
Lipoadenoma of the Parathyroid Gland: Characterization of an Institutional Series Spanning 28 Years
AbstractParathyroid lipoadenomas (PLAs) are rare tumors, and case descriptions are limited,< 80 to date. As a consequence, scarce information regarding the etiology of these enigmatic lesions is available. We searched our departmental pathology database for PLAs diagnosed between 1992 and 2020, reexamined the histology of each case, and recorded clinical parameters from the patients’ m edical charts. As the diagnostic criteria of this lesion vary over this time period, we defined PLA as an enlarged parathyroid gland with> 50% fat on histologic examination with preoperative evidence of primary hyperparathyroid...
Source: Endocrine Pathology - March 18, 2020 Category: Pathology Source Type: research
Utility of GATA-3 Expression in the Analysis of Pituitary Neuroendocrine Tumour (PitNET) Transcription Factors
AbstractWith the introduction of the WHO 2017 classification of endocrine neoplasms, the use of the pituitary transcription factors PIT-1, Tpit and SF-1 has become the standard of care. However, immunohistochemistry for these transcription factors is not available in all institutions, and their reliability has been questioned. We read with interest the findings of Mete et al. that GATA-3 expression was detected in some pituitary neuroendocrine tumours (PitNET). We therefore sort to validate this in our large cohort of PitNETs. We searched the database of Royal North Shore Hospital for PitNETs between 1998 and 2012, constru...
Source: Endocrine Pathology - March 18, 2020 Category: Pathology Source Type: research
Book Review on “The Survival Guide to Endocrine Pathology (Pathology Survival Guides Series 1, Volume 4) by Sylvia L. Asa, MD, PhD”
(Source: Endocrine Pathology)
Source: Endocrine Pathology - March 18, 2020 Category: Pathology Source Type: research
Frequency and Role of CDKN2A Deletion in High-Risk Pituitary Neuroendocrine Tumors
AbstractThe underlying mechanisms of aggressive pituitary neuroendocrine tumors (pitNETs) are still unclear. The p16 protein, encoded by theCDKN2A tumor suppressor gene on chromosome 9p21, is commonly reported to be lost in numerous types of cancer. For this reason, this study examined to examine the status of homozygous deletion ofCDKN2A in high-risk pitNETs. Thirty-eight high-risk pitNETs (30 male, 8 female) were analyzed forCDKN2A deletion by fluorescent in situ hybridization (FISH). Demographic characteristics such as sex, patient age at operation, and sellar magnetic resonance imaging findings including tumor size and...
Source: Endocrine Pathology - March 8, 2020 Category: Pathology Source Type: research
Practice Paradigms Before and After Introduction of the Diagnosis-Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP): an Institutional Experience
AbstractThe recently adopted terminology of “Noninvasive follicular thyroid neoplasm with papillary-like nuclear features” (NIFTP) reflects the indolent behavior of these tumors. In contrast to conventional papillary thyroid carcinomas, NIFTP can be managed conservatively. The purpose of this study was to investigate changes in surgical a nd pathologic practice patterns at our institution since the introduction of the NIFTP diagnosis in 2016. A retrospective analysis of all thyroid specimens received in our laboratory between January 2015 and April 2017 was performed. The final cohort consisted of 1508 thyroidectomy sp...
Source: Endocrine Pathology - March 6, 2020 Category: Pathology Source Type: research
Images in Endocrine Pathology: High-Grade Intrathyroidal Parathyroid Carcinoma with Crooke ’s Hyalinization
(Source: Endocrine Pathology)
Source: Endocrine Pathology - March 6, 2020 Category: Pathology Source Type: research
Homogeneous MMR Deficiency Throughout the Entire Tumor Mass Occurs in a Subset of Colorectal Neuroendocrine Carcinomas
AbstractNeuroendocrine neoplasms comprise a heterogeneous group of tumors, categorized into neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs) depending on tumor differentiation. NECs and high-grade NETs (G3) confer a poor prognosis, demanding novel treatment strategies such as immune checkpoint inhibition in tumors with microsatellite instability (MSI). To study any possible intratumoral heterogeneity of MSI, a tissue microarray (TMA) containing 199 NETs and 40 NECs was constructed to screen for MSI using immunohistochemistry (IHC) for the mismatch repair (MMR) proteins MLH1, PMS2, MSH2, and MSH6. Four case...
Source: Endocrine Pathology - March 5, 2020 Category: Pathology Source Type: research
Immunohistochemical Profile and 47-Gene Next-Generation Sequencing (NGS) Solid Tumor Panel Analysis of a Series of 13 Strumal Carcinoids
AbstractStrumal carcinoid is an extraordinary rare tumor of the ovary consisting of thyroid tissue intermixed with neuroendocrine tumor component. The cellular origin of strumal carcinoids has been an area of debate. There is also little data on detailed immunohistochemical and molecular characteristics of these neoplasms. For this reason, this series investigated the characteristics of a series of 13 strumal carcinoids using immunohistochemical markers and a 47-gene next-generation sequencing (NGS) solid tumor panel analysis. Both cellular components showed thyroglobulin expression in all tumors. TTF-1 expression was note...
Source: Endocrine Pathology - March 1, 2020 Category: Pathology Source Type: research
Alternative Lengthening of Telomeres and Differential Expression of Endocrine Transcription Factors Distinguish Metastatic and Non-metastatic Insulinomas
AbstractInsulin-producing pancreatic neuroendocrine tumors (PanNETs)/insulinomas are generally considered to be indolent tumors with an excellent prognosis after complete resection. However, some insulinomas have a poor prognosis due to relapses and metastatic disease. Recently, studies in non-functional PanNETs indicated that behavior can be stratified according to alpha- and beta-cell differentiation, as defined by expression of the transcription factors ARX and PDX1, respectively. It is unknown whether similar mechanisms play a role in insulinomas. Therefore, we determined ARX and PDX1 expression in a cohort of 35 spora...
Source: Endocrine Pathology - February 25, 2020 Category: Pathology Source Type: research
Message from the New Editor-in-Chief of Endocrine Pathology
(Source: Endocrine Pathology)
Source: Endocrine Pathology - February 14, 2020 Category: Pathology Source Type: research
Germline Mutations in Familial Papillary Thyroid Cancer
In this study, the genetic basis of hereditary PTC in three Brazilian families was investigated. Whole exom e sequencing (WES) was carried out for probands in each family, and validated, pathogenic/likely pathogenic sequence variants (P/LPSVs) were genotyped in additional family members to establish their putative pathogenic role. Overall, seven P/LPSVs in seven novel genes were detected: p.D283N*ANXA3, p.Y157S*NTN4, p.G172W*SERPINA1, p.G188S*FKBP10, p.R937C*PLEKHG5, p.L32Q*P2RX5, and p.Q76*SAPCD1. These results indicate that these novel genes are seemingly associated with hereditary PTC, but extension and validation in ot...
Source: Endocrine Pathology - February 7, 2020 Category: Pathology Source Type: research
Metastatic Anaplastic Thyroid Carcinoma in Complete Remission: Morphological, Molecular, and Clinical Work-Up of a Rare Case
We describe a 64-year-old male who developed a rapidly growing mass in the left thyroid lobe. A fine-needle aspiration biopsy (FNAB) was consistent with ATC, and the patient underwent preoperative combined chemo- and radiotherapy followed by a hemithyroidectomy. The ensuing histopathological investigation was consistent with ATC adjoined by an oxyphilic well-differentiated lesion, likely a H ürthle cell carcinoma. Tumor margins were negative, and no extrathyroidal extension was noted. Focused next-generation sequencing analysis of the primary tumor tissue identified aTP53 gene mutation but could not identify any potential...
Source: Endocrine Pathology - February 2, 2020 Category: Pathology Source Type: research
