Current Treatment Options in Allergy Current Treatment Options in Allergy RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Diagnosis and Management of Allergic Conjunctivitis
AbstractPurpose of the reviewThe purpose of this review is to define the classification, diagnosis, and management in adults and children with allergic conjunctivitis with emphasis on recent findings.Recent findingsCurrent literature divides allergic conjunctivitis according to severity and frequency, facilitating its diagnosis, study, and treatment choices. Novel pharmacological therapies aim at inhibiting inflammatory pathways at a specific molecular level and include selective glucocorticoid receptor agonists, kinase inhibitors, and IL-1 receptor antagonists.SummaryOcular allergies are a group of heterogeneous diseases ...
Source: Current Treatment Options in Allergy - April 27, 2018 Category: Allergy & Immunology Source Type: research

Use of a Combination of Allergen Immunotherapy and Omalizumab for Prevention of Anaphylaxis
AbstractPurpose of reviewAllergen immunotherapy (AIT) is aimed at the etiological treatment of respiratory allergy and Hymenoptera venom allergy, while it is still under investigation for food allergy. The incidence of anaphylactic reactions to AIT is generally low, but may hamper its completion and makes needed preventive treatment.Recent findingsSeveral studies focused the attention on the use of the anti-IgE antibody omalizumab to prevent anaphylaxis in patients at high risk of systemic reactions, that is especially elevated during food allergy AIT and, in certain circumstances, during venom immunotherapy (VIT).SummaryW...
Source: Current Treatment Options in Allergy - April 23, 2018 Category: Allergy & Immunology Source Type: research

Impact and Assessment of Sleep Disturbance in Adults and Children with Allergic Rhinitis
AbstractPurpose of ReviewIn this article, we review the impact and the treatment of sleep disturbance caused by allergic rhinitis (AR) in adult and pediatric patients.Recent FindingsAlthough intranasal corticosteroids (INS) remain the mainstay treatments for AR-induced sleep disturbance, allergen immunotherapy (AIT) has been suggested to be effective in altering the course and progression of moderate-to-severe AR that is refractory to pharmacotherapy. MP-AzeFlu is a recently developed formulation containing azelastine, an intranasal antihistamine (INAH), and fluticasone propionate, an INS. MP-AzeFlu has been reported to ha...
Source: Current Treatment Options in Allergy - April 20, 2018 Category: Allergy & Immunology Source Type: research

An Update on the Management of Anaphylaxis
AbstractPurpose of reviewTo highlight the latest evidence supporting management recommendations in anaphylaxis and discuss the implications for further research in anaphylaxis management.Recent findingsThe acute management of anaphylaxis is largely centered on resuscitation and administration of epinephrine. There is little evidence to support the use of antihistamines and corticosteroids in the acute management of anaphylaxis.SummaryAnaphylaxis is an acute, systemic, potentially life-threatening reaction caused by the release of mast cell and basophil mediators that could lead to distributive shock. Anaphylaxis is associa...
Source: Current Treatment Options in Allergy - April 20, 2018 Category: Allergy & Immunology Source Type: research

Precision Medicine in the Management of Drug Allergy
AbstractPurpose of studyThe term precision medicine has been developed in the last five or more years to describe the concept of treating patients individually based on a variety of factors. Precision medicine can be applied to the field of drug allergy where phenotypes, endotypes, and biomarkers have been defined.Recent findingsPhenotypes of drug allergy can be based on (1) the mechanism of the underlying reaction; (2) the clinical presentation of the reaction; and (3) the timing of the reaction in regards to exposure to the drug. Endotypes of drug allergy can be defined based on mechanisms, pharmacologic processes, and h...
Source: Current Treatment Options in Allergy - February 15, 2018 Category: Allergy & Immunology Source Type: research

Lessons of Drug Allergy Management Through the World Health Organization ’s International Classification of Diseases (ICD)-11
AbstractPurposes of reviewIn order to introduce the advances and use of the new sub-section addressed to the drug hypersensitivity reactions (DHRs) in the World Health Organizations ’ International Classification of Diseases (ICD)-11 revision, we here proposed a used case document and discuss the perspective of this new framework.Recent findingsWe expect that the construction of the new section addressed to DHRs in the ICD-11 will allow the collection of more accurate epidemiological data to support quality management of patients with drug allergies, and better facilitate health care planning to implement public health m...
Source: Current Treatment Options in Allergy - February 9, 2018 Category: Allergy & Immunology Source Type: research

Occupational Asthma, Not a Trivial Disorder and a Source of Fatal and N ear-Fatal Events
Opinion statementPurpose of reviewAsthma is one of our society ’s heaviest health burdens, which is estimated to be responsible for 250,000 deaths every year. Whenever severe asthma with fatal or near-fatal events is described, occupational asthma is not specifically mentioned, but its importance should not be underestimated.Recent findingsOccupational asthma (OA) is the most prevalent work-related pulmonary disease. Therefore, it is a very important concern for health prevention and occupational health professionals. Although asthma treatments and earlier diagnosis have improved this condition ’s control, severe exace...
Source: Current Treatment Options in Allergy - February 7, 2018 Category: Allergy & Immunology Source Type: research

How to Manage Antibiotic Allergy in Cystic Fibrosis? Epidemiologic, Diagnostic, and Therapeutic Aspects
AbstractPurpose of studyCystic fibrosis (CF) is a complex genetic disease with high mortality, of which 85% is a result of lung disease characterized by serious endobronchial infections.Recent findingsAntibiotic therapy is one of the main treatments of CF, both during acute exacerbations and as chronic maintenance medications, contributing to a prolonged survival. Since neonatal CF screening programs have been implemented universally and the longevity of patients with CF steadily increases, antibiotic hypersensitivity reactions (HSRs) are becoming more important. HSR to antibiotics in CF has been reported since the 1980s a...
Source: Current Treatment Options in Allergy - February 6, 2018 Category: Allergy & Immunology Source Type: research

Asthma and Cleaning: What ’s New?
AbstractProfessional and domestic cleanings are associated with work-related asthma (WRA). Increased risk of asthma has been shown in many epidemiological and surveillance studies, and several case reports describe the relationship between exposure to one or more cleaning agents and WRA. Moreover, exposure to cleaning chemicals could be associated with severe uncontrolled asthma. Cleaning sprays, bleach, ammonia, disinfectants, mixing products, and specific job tasks have been identified as specific causes and/or triggers of asthma or airway respiratory diseases. Their measurements at the workplace could be interesting but...
Source: Current Treatment Options in Allergy - February 2, 2018 Category: Allergy & Immunology Source Type: research

Options in Hypersensitivity Reactions to Chemotherapeutics
This article has tried to highlight and summarize the most recent scientific progress concerning risk factors, pathogenesis, diagnosis, and treatment of these reactions.Recent findingsIdentification of patients at high risk of developing hypersensitivity reactions allows risk stratification to guide clinical decision-making. Therefore, the most recent researches evaluated the possibility to perform risk stratification in case of hypersensitivity reactions to platinum compounds and taxanes. In addition, new data are now available regarding the role of in vitro test for the diagnosis of reactions to platins and the role of d...
Source: Current Treatment Options in Allergy - January 30, 2018 Category: Allergy & Immunology Source Type: research

Hypersensitivity Reactions to Iodinated Contrast Media: Is it a True Allergy?
Opinion statementClassically, hypersensitivity reactions to iodinated contrast media (ICM) have been termed pseudoallergic, allergy-like, or anaphylactoid. The origin of these terms to define ICM hypersensitivity reactions could be in relation to the use of traditional, classic, ionic ICMs. These ionic ICMs have a high osmolality, and the reactions have been considered as secondary to non-specific histamine release. Currently, ionic ICMs have been replaced by non-ionic compounds with low or iso-osmolality, which, although to a lesser extent, can also produce hypersensitivity reactions. In recent years, there has been growi...
Source: Current Treatment Options in Allergy - January 29, 2018 Category: Allergy & Immunology Source Type: research

Allergic Contact Dermatitis: Therapeutic Management
AbstractPurpose of ReviewAllergic contact dermatitis (ACD) is a common condition and may entail negative impacts on people ’s quality of life along with a substantial economic burden. Appropriately managing it through patient education, allergen avoidance, and symptomatic treatment is crucial for its resolution. Our review aims to establish a practical approach to ACD management, based on a comprehensive discussion of available therapeutic options for ACD, a review of the latest findings in this field, and personal insights from our clinical practice experience.Recent FindingsTopical treatments constitute the first-line ...
Source: Current Treatment Options in Allergy - January 25, 2018 Category: Allergy & Immunology Source Type: research

How Can We Influence the Performance of Drug Challenge in Future Treatment
AbstractDrug provocation tests are assumed to be the gold standard of drug allergy workup by ensuring the most objective results in clinical observation irrespective of the underlying mechanism of the reaction. Despite its some disadvantages, it is still one of the cornerstones of the drug allergy diagnosis. In this review, new methods for improving diagnostic accuracy of drug provocation tests will be discussed. In this sense, extended challenges are recently shown to have better outcome especially in diagnosing non-immediate reactions due to antibiotics. In children with non-immediate mild cutaneous reactions, provocatio...
Source: Current Treatment Options in Allergy - January 25, 2018 Category: Allergy & Immunology Source Type: research

Anaphylaxis in the Workplace
AbstractOccupational anaphylaxis (OcAn) main causes comprise food, medications, insect stings/bites, and natural rubber latex (NRL). An in-depth investigation is required, before labeling a reaction as OcAn.A written emergency management plan, health and safety education, and training and surveillance should be implemented after proper diagnosis. Education on when and how to use the adrenaline auto-injector device should be provided likewise. Moreover, surveillance and advice on risk of allergen exposure and how to minimize their risk of sensitization at the beginning of their employment or training is mandatory. Workers w...
Source: Current Treatment Options in Allergy - January 22, 2018 Category: Allergy & Immunology Source Type: research

Mast Cell Activation Syndromes and Environmental Exposures
Opinion statementMast cell activation syndromes (MCAS) are an emerging entity that includes a heterogeneous group of diseases presenting with typical signs and symptoms secondary to the release of mast cell (MC) mediators. Triggering factors underlying the activation of mast cells show a wide variability, and episodes of MC-mediator release are usually triggered by idiopathic or by mixed causes, which makes avoidance recommendations difficult to devise. Sometimes, environmental or occupational exposures are responsible for MC activation. In this article, we review the main workplace environment eliciting factors described ...
Source: Current Treatment Options in Allergy - January 20, 2018 Category: Allergy & Immunology Source Type: research