Current Treatment Options in Allergy 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.What Do We Really Know About Intralymphatic Immunotherapy?
AbstractPurpose of reviewAllergen-specific immunotherapy (AIT) is the only causal treatment method of IgE-mediated allergies that may lead to long-term symptom amelioration even after the end of treatment, positively interfere with the course of disease, and improve the immunological situation of the patient. While AIT in general requires treatment periods over 3 up to 5 years, intralymphatic immunotherapy (ILIT) needs only three ultrasound-guided injections of low allergen doses into inguinal lymph nodes with 4-week time interval making the entire treatment possible within 2 months.Recent findingsThe number of publishe...
Source: Current Treatment Options in Allergy - September 15, 2018 Category: Allergy & Immunology Source Type: research
Duration of Allergen Immunotherapy for Long-Term Efficacy in Allergic Rhinoconjunctivitis
AbstractRationaleSubcutaneous and sublingual immunotherapy are effective for allergic rhinitis. An important question is whether allergen immunotherapy provides a sustained clinical effect after treatment cessation. In view of potential side effects, cost and the necessary patient commitment, long-term benefit is an important consideration for the recommendation of immunotherapy over standard pharmacotherapy.Purpose of reviewIn this review, we analyse the existing evidence for long-term effects of both routes of administration in the context of double-blind, placebo-controlled, randomised clinical trials that included a fo...
Source: Current Treatment Options in Allergy - September 1, 2018 Category: Allergy & Immunology Source Type: research
Nettle Allergy: a Review and Clinical Perspective
The objectives of this article are to review the available literature regarding the geographic distribution of nettle, allergen(s) involved, cross-reactivity, role in allergic rhinitis, immunotherapy efficacy, and provide a clinical perspective on the evaluation and treatment of nettle sensitized patients.Recent findingsStinging nettle (Urtica dioica) is a bi-annual pollinator with worldwide distribution and wide use in homeopathy. Limited data suggest that nettle pollen allergens may be considered clinically relevant and that nettle pollen allergy may be underestimated. More recent allergomic analysis of nettle pollen has...
Source: Current Treatment Options in Allergy - September 1, 2018 Category: Allergy & Immunology Source Type: research
Mechanism of Synthetic Peptide Immuno-Regulatory Epitopes and Their Clinical Efficacy in the Treatment of Allergic Disease
AbstractPurpose of reviewPeptide immunotherapy with synthetic peptide immuno-regulatory epitopes (SPIREs) is a safer alternative to conventional allergen immunotherapy (AIT) owing to the reduced risk of IgE-mediated adverse reactions and shorter treatment schedules. Over the last 5 years, significant advances have been made in evaluating SPIREs for the treatment of allergic rhinitis. This review includes a summary of recent phase II and III clinical trials evaluating the efficacy of SPIREs and a brief discussion on their mechanism of action.Recent findingsTo date, SPIREs have been developed for cat, house dust mite (HDM)...
Source: Current Treatment Options in Allergy - September 1, 2018 Category: Allergy & Immunology Source Type: research
Contact Urticaria and Protein Contact Dermatitis —a Frequently Hidden Diagnosis
AbstractPurpose of reviewWe hope that this review can assist in the classification, diagnosis, prevention, and treatment of a contact urticaria syndrome (CUS), a syndrome in which the understanding of such is still evolving.Recent findingsCUS and protein contact dermatitis (PCD) can be defined as an immediate inflammatory reaction of the skin following contact with an external substance. Erythema, wheals, and eczema, as well as other manifestations can occur as a result of this inflammatory reaction. Many low molecular weight substances and proteins are known to produce these immediate skin contact reactions. These reactio...
Source: Current Treatment Options in Allergy - September 1, 2018 Category: Allergy & Immunology Source Type: research
Duration of Allergen Immunotherapy for Long-Term Efficacy in Allergic Rhinoconjunctivitis
AbstractRationaleSubcutaneous and sublingual immunotherapy are effective for allergic rhinitis. An important question is whether allergen immunotherapy provides a sustained clinical effect after treatment cessation. In view of potential side effects, cost and the necessary patient commitment, long-term benefit is an important consideration for the recommendation of immunotherapy over standard pharmacotherapy.Purpose of reviewIn this review, we analyse the existing evidence for long-term effects of both routes of administration in the context of double-blind, placebo-controlled, randomised clinical trials that included a fo...
Source: Current Treatment Options in Allergy - August 31, 2018 Category: Allergy & Immunology Source Type: research
Mechanism of Synthetic Peptide Immuno-Regulatory Epitopes and Their Clinical Efficacy in the Treatment of Allergic Disease
AbstractPurpose of reviewPeptide immunotherapy with synthetic peptide immuno-regulatory epitopes (SPIREs) is a safer alternative to conventional allergen immunotherapy (AIT) owing to the reduced risk of IgE-mediated adverse reactions and shorter treatment schedules. Over the last 5 years, significant advances have been made in evaluating SPIREs for the treatment of allergic rhinitis. This review includes a summary of recent phase II and III clinical trials evaluating the efficacy of SPIREs and a brief discussion on their mechanism of action.Recent findingsTo date, SPIREs have been developed for cat, house dust mite (HDM)...
Source: Current Treatment Options in Allergy - July 18, 2018 Category: Allergy & Immunology Source Type: research
Nettle Allergy: a Review and Clinical Perspective
The objectives of this article are to review the available literature regarding the geographic distribution of nettle, allergen(s) involved, cross-reactivity, role in allergic rhinitis, immunotherapy efficacy, and provide a clinical perspective on the evaluation and treatment of nettle sensitized patients.Recent findingsStinging nettle (Urtica dioica) is a bi-annual pollinator with worldwide distribution and wide use in homeopathy. Limited data suggest that nettle pollen allergens may be considered clinically relevant and that nettle pollen allergy may be underestimated. More recent allergomic analysis of nettle pollen has...
Source: Current Treatment Options in Allergy - July 16, 2018 Category: Allergy & Immunology Source Type: research
The Association Between Ambient Air Pollution and Allergic Rhinitis Inception and Control
This article summarizes the main consequences of the complex relationship that exists between allergic rhinitis, environmental pollution, and climate change and presents some potential measures aiming at modifying some aspects of this intriguing relationship to achieve a clinical benefit in patients suffering from allergic diseases, especially allergic rhinitis. (Source: Current Treatment Options in Allergy)
Source: Current Treatment Options in Allergy - June 1, 2018 Category: Allergy & Immunology Source Type: research
Food-Dependent Exercise-Induced Anaphylaxis
AbstractPurpose of reviewFood-dependent exercise-induced anaphylaxis (FDEIA) is a form of anaphylaxis that occurs associated with exercise, in which symptoms develop by the combination of food ingestion and physical activity. We aimed to review and discuss the main clinical recommendations for management of FDEIA, focusing on individual factors.Recent findingsNew diagnostic strategies have been developed to optimize the accuracy of provocation challenges, taking in consideration augmenting factors, such as alcohol or non-steroidal anti-inflammatory drugs. However, FDEIA is still insufficiently diagnosed and a high index of...
Source: Current Treatment Options in Allergy - June 1, 2018 Category: Allergy & Immunology Source Type: research
Are Large Local Reactions Useful to Predict Future Anaphylaxis to Hymenoptera Stings?
AbstractPurpose of reviewUnaware of the natural history of large local reactions caused by Hymenoptera stings, patients and clinicians are often concerned when faced with these reactions. These concerns include the difficulty in avoiding stings, the local discomfort, and the fear that the local reaction portends systemic, potentially life-threatening subsequent reactions. This review presents the historical studies that have assessed the natural history of large local reactions caused by Hymenoptera stings and, in doing so, provides rationale for the current consensus guidelines for the management of these reactions.Recent...
Source: Current Treatment Options in Allergy - June 1, 2018 Category: Allergy & Immunology Source Type: research
ARIA 2017: a Review of Major Changes and Innovations
ConclusionARIA guideline has evolved to a technology-based implementation strategy to help rhinitis sufferers to have an active and healthy life and to reduce health and social inequalities caused by this very common disease, irrespective of their age, sex, or socio-economic status. (Source: Current Treatment Options in Allergy)
Source: Current Treatment Options in Allergy - June 1, 2018 Category: Allergy & Immunology Source Type: research
Use of a Combination of Allergen Immunotherapy and Omalizumab for Prevention of Anaphylaxis
AbstractPurpose of reviewAllergen immunotherapy (AIT) is aimed at the etiological treatment of respiratory allergy and Hymenoptera venom allergy, while it is still under investigation for food allergy. The incidence of anaphylactic reactions to AIT is generally low, but may hamper its completion and makes needed preventive treatment.Recent findingsSeveral studies focused the attention on the use of the anti-IgE antibody omalizumab to prevent anaphylaxis in patients at high risk of systemic reactions, that is especially elevated during food allergy AIT and, in certain circumstances, during venom immunotherapy (VIT).SummaryW...
Source: Current Treatment Options in Allergy - June 1, 2018 Category: Allergy & Immunology Source Type: research
