Current Treatment Options in Allergy Current Treatment Options in Allergy RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Biologics in Treatment for Chronic Rhinosinusitis with Comorbid Asthma
AbstractPurpose of ReviewIt is reported that the prevalence of asthma is as high as 25% in patients with CRS, resulting in prolonged inflammation and recurrence. The remission of asthma has been found to be highly significant in contribution to the remission of CRS; hence, the usage of biologics treatment for asthma can be expanded towards the treatment for CRS with asthma. In this review, we summarized the usage of biologics in CRS with asthma treatment, their mechanisms, and future biologics in the development pipeline that would aid treatment for CRS with asthma.Recent FindingsChronic rhinosinusitis is an inflammatory d...
Source: Current Treatment Options in Allergy - April 7, 2021 Category: Allergy & Immunology Source Type: research

Cereal Anaphylaxis
AbstractPurpose of reviewTo summarize the current understanding and important aspects of anaphylaxis related to cereal grains.Recent findingsSkin applied products have recently shown to be associated with cereal anaphylaxis; advances in wheat antigen investigation are discussed; new evidence of cereal cross-reactivity; and oral immunotherapy has been attempted with some success.SummaryCereal grains have been shown to cause anaphylaxis. Recent investigation into wheat antigens has led to identification of possible markers for WDEIA and wheat allergy. Cereal cross-reactivity has been noted, which is clinically relevant when ...
Source: Current Treatment Options in Allergy - March 22, 2021 Category: Allergy & Immunology Source Type: research

Management of Anaphylaxis During the SARS-CoV-2 Pandemic
AbstractPurpose of ReviewManagement of anaphylaxis during the SARS-CoV-2 pandemic should consider local infection rates so as to not burden local ED at times of pandemic, while also protecting patients from infection risks and progression of anaphylaxis. In this review, we identify a treatment strategy for anaphylaxis that balances the risks versus benefits of ED versus home management in this unprecedented time.Recent FindingsPhysicians and patients have had to adapt new approaches to medical care during the SARS-CoV-2 pandemic due to restricted access to health care facilities. Telemedicine has substituted in-person visi...
Source: Current Treatment Options in Allergy - March 10, 2021 Category: Allergy & Immunology Source Type: research

Allergen Preparation in AIT, Now and in the Future
Opinion StatementPurpose of ReviewAt present,in vivo allergy diagnosis and allergen-specific immunotherapy (AIT) are still based on allergens extracted from natural material. The inherent content and activity change of allergen source cannot be resolved, which impedes the standardization of AIT and limits doctors ’ desire to recommend it.Recent FindingsWith the increasing use of allergen molecules in allergy diagnosis, the molecular allergens in AIT are believed to be the future trend. However, the current clinical phase III trials are not satisfying. Improvements have been made in the field of allergen extracts or molec...
Source: Current Treatment Options in Allergy - March 5, 2021 Category: Allergy & Immunology Source Type: research

Management of Pet Allergies in Children in China
AbstractPurpose of the reviewWith the increase in pet keeping among families in China, there has been a corresponding increase in the incidence of allergic diseases such as bronchial asthma and allergic rhinoconjunctivitis. Pet allergies pose important social and health problems, making their management in children crucial.Recent findingsThere is an increasing trend of sensitization to cat and dog dander among Chinese children. The process underlying allergic sensitization is complex and is associated with an IgE-mediated type I hypersensitivity reaction that involves the upregulation of type 2 T-helper (Th2) cells, result...
Source: Current Treatment Options in Allergy - February 23, 2021 Category: Allergy & Immunology Source Type: research

The Impact of Climate Change on the Pollen Allergy and Sporulation of Allergic Fungi
AbstractPurpose of reviewThe purpose of this chapter is to review allergic disease and how it is potentially impacted by climate change. It is difficult to measure the direct impact climate change has on allergic disease. This is difficult because there are many variables impacting human health as well as what capacity humans have to adapt to these changes. Asthma is tightly associated with allergies and environmental factors, especially in children. In this review, we will explore evidence of environmental changes associated with climate change and the potential impacts on allergy and associated respiratory disease. Furth...
Source: Current Treatment Options in Allergy - January 29, 2021 Category: Allergy & Immunology Source Type: research

Patients ’ Perspectives and Needs on Novel Food Allergy Treatments in the United States
AbstractPurposeFood allergy management places a daily psychosocial burden on patients and their caregivers. New food allergy treatments may positively impact their lives, but also introduce new stressors. The purpose of this paper is to provide an overview of the current state of the literature regarding patients ’ and caregivers’ food allergy experiences and needs within the United States as well as a set of recommendations regarding how best to proceed with patient-centered development and evaluation of new food allergy treatments.Recent findingsThe first pharmaceutical-grade product for peanut oral immunotherapy was...
Source: Current Treatment Options in Allergy - January 23, 2021 Category: Allergy & Immunology Source Type: research

Ubiquity, Hazardous Effects, and Risk Assessment of Fragrances in Consumer Products
AbstractPurpose of reviewThe main aims of fragrances are to create pleasing scents or to mask unpleasant odors. We hereby review their main exposure sources, presumed benefits, and unwanted effects, with special attention to allergic contact dermatitis (prevalence, regulatory environment, risk assessment methodology, and preventive measures).Recent findingsFragrances elicit positive emotions and presumably have therapeutic benefits related to stress reduction and memory enhancement. However, they also cause detrimental health or environmental effects including contact dermatitis (irritant and/or allergic), non-eczematous c...
Source: Current Treatment Options in Allergy - January 23, 2021 Category: Allergy & Immunology Source Type: research

Genetic Variants Associated With Drug-Induced Hypersensitivity Reactions: towards Precision Medicine?
AbstractPurpose of reviewDrug hypersensitivity represents an important problem for health care and patient ’s management, as they limit therapeutic decisions, hampering treatment and being a frequent cause of complications during hospitalization, and, in some instances, being life threatening. The risk of developing drug hypersensitivity reactions depends not only on some specific individual characteri stics but it seems to be also influenced by genetic factors. The identification of such factors could conceivably help to their diagnosis and prevention, avoiding therapeutic failure and leading to the development of preci...
Source: Current Treatment Options in Allergy - January 18, 2021 Category: Allergy & Immunology Source Type: research

Choosing the Optimal Self-Injector Epinephrine
AbstractPurpose of reviewAnaphylaxis is an acute, systemic, life-threatening allergic reaction, and its choice treatment is epinephrine. Epinephrine may be administered by several routes, but intramuscular is the preferred one because of its fast time of action, as well as easy access. Several devices are commercially available for self-administration, with some differences between them. There are concerns about defects or errors in administration when using autoinjectors.Recent findingsThe main factors that determine the correct use of an autoinjector are the length of needle, body mass index, use of clothing, type of dev...
Source: Current Treatment Options in Allergy - January 4, 2021 Category: Allergy & Immunology Source Type: research

The Challenge of Establishing the Burden of Anaphylaxis: Some Recent Trends
AbstractPurpose of reviewThis review aims to describe some of the limitations in defining anaphylaxis and therefore the difficulties in studying its epidemiology. Despite these limitations we also aim to describe some of the trends observed in recent studies.Recent findingsThe epidemiological study of anaphylaxis is problematic. Although first described over 100  years ago, the definition of anaphylaxis has undergone revision in the last 2 decades, and a new international consensus definition was proposed in 2014. Clinical diagnostic criteria have been in use for little over a decade. Mast cell tryptase can be used to con...
Source: Current Treatment Options in Allergy - November 26, 2020 Category: Allergy & Immunology Source Type: research

Progress in Anisakis Allergy Research: Milestones and Reversals
AbstractPurpose of the reviewAnisakis has gained cosmopolitan celebrity mainly through its potential to induce allergic disease. In the last two decades, several regions in the world, including the Mediterranean region, Japan, or Korea have reported high numbers of Anisakiasis-accompanied allergic symptoms: Gastro-allergic Anisakiasis.Recent findingsRecent wide-scale epidemiological studies highlight the global scenario ofAnisakis for human health, and awareness is the main contributing factor. After two decades of research in the field ofAnisakis allergy, in the last years, molecular studies ofAnisakis allergens including...
Source: Current Treatment Options in Allergy - September 9, 2020 Category: Allergy & Immunology Source Type: research

Current Management of Juvenile Nasopharyngeal Angiofibroma
AbstractPurpose of reviewThe purpose of this article is to provide a current review of the most important management principles for evaluation and treatment of juvenile nasopharyngeal angiofibroma.Recent findingsNumerical staging systems have been adapted many times over the years, but a new nominal staging system based on specific anatomical site involvement and residual internal carotid artery vascularization helps to provide a more comprehensive alternative for evaluation. An expanding body of evidence supports the use of an endoscopic surgical approach to reduce risk of tumor recurrence and reduce intraoperative blood ...
Source: Current Treatment Options in Allergy - August 27, 2020 Category: Allergy & Immunology Source Type: research

The Present and Future Burden of Contact Dermatitis from Acrylates in Manicure
AbstractPurpose of Review(Meth)acrylates are chemical compounds used in a wide variety of settings such as nail esthetics and the medical field. A progressive increase in the frequency of acrylate-induced sensitization likely caused by the popularity and wide-spread use of semi-permanent polishes has been described.Recent FindingsSeveral factors contribute to such scenario including the insufficient training of beauticians regarding the risks posed by the manipulation of acrylate-based manicure materials, the fact that some consumers end up self-applying these products at home, and the poor training of the general dermatol...
Source: Current Treatment Options in Allergy - August 17, 2020 Category: Allergy & Immunology Source Type: research

The Role of Biologics and Precision-Based Medicine in Treating Atopic Diseases in Children
AbstractPurpose of ReviewChildren with atopic diseases such as asthma and atopic dermatitis often have poorly controlled disease, which can occur as a result of noncompliance from the concern of side effects from prolonged use of medications. This fear is not unfounded as often increasing doses of inhaled, topical, or oral steroids are required for control and carry a cumulative risk burden for growth and development in this population. The availability of biologics in this patient population has been pivotal in expanding options to reduce disease burden and unfavorable side effects.Recent FindingsIn addition to biologics ...
Source: Current Treatment Options in Allergy - August 16, 2020 Category: Allergy & Immunology Source Type: research