Nettle Allergy: a Review and Clinical Perspective

The objectives of this article are to review the available literature regarding the geographic distribution of nettle, allergen(s) involved, cross-reactivity, role in allergic rhinitis, immunotherapy efficacy, and provide a clinical perspective on the evaluation and treatment of nettle sensitized patients.Recent findingsStinging nettle (Urtica dioica) is a bi-annual pollinator with worldwide distribution and wide use in homeopathy. Limited data suggest that nettle pollen allergens may be considered clinically relevant and that nettle pollen allergy may be underestimated. More recent allergomic analysis of nettle pollen has revealed protein allergens including an osmotin and a pectin esterase which may implicate cross-reactivity with other pollens and foods. One study describes in vivo nettle immunotherapy.SummaryOverall, there is a paucity of medical literature evaluating the role of nettle in allergic rhinitis with even fewer studies assessing the clinical efficacy of nettle immunotherapy. Cross-reactivity patterns with other pollens and foods remains to be fully elucidated. Given the immense medical and economic impact of allergic rhinitis and the worldwide distribution of nettle, prospective randomized controlled trials are needed to evaluate the possible contribution of nettle allergy and efficacy of nettle immunotherapy.
Source: Current Treatment Options in Allergy - Category: Allergy & Immunology Source Type: research

Related Links:

Abstract Histamine, acting predominantly via the H1-receptor, is an important mediator of the symptoms of allergy, and H1-antihistamines, which stabilise the receptor in its inactive form, are the treatment of choice for some chronic allergic conditions. Ebastine is a well-established oral second-generation H1-antihistamine. It is administered once daily at a dose of 10-20 mg and is available as a standard tablet and also as a fast-dissolving tablet that disintegrates in the mouth. Ebastine has demonstrated to be efficacious at relieving symptoms in patients with allergic rhinitis or urticaria in multiple clinical...
Source: Journal of Investigational Allergology and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: J Investig Allergol Clin Immunol Source Type: research
ConclusionsOmalizumab appears to be an excellent therapeutic option in children with inadequately controlled severe allergic asthma, allergic rhinitis and rhinosinusitis, with or without food allergy.
Source: Italian Journal of Pediatrics - Category: Pediatrics Source Type: research
Conclusions: In the CAR registry, patients with SAA treated with omalizumab showed a significant positive effect of anti-IgE therapy not only on the asthma control, but also on allergic comorbidities. PMID: 30429711 [PubMed]
Source: Advances in Dermatology and Allergology - Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research
Allergic diseases are of great concern because of their high prevalence, which is still rising in several regions, their impact on patients ’ physical and psychological health, the huge burden they place on patients’ quality of life, as well as the socioeconomic consequences that they cause. Recent research has provided new data on both genetic and environmental risk factors of atopic/allergic diseases. The application of new techno logies such as “omics” has allowed a better understanding of the pathogenesis and has helped with the identification of therapeutic targets. Immense progress has been ma...
Source: International Archives of Allergy and Immunology - Category: Allergy & Immunology Source Type: research
Exercise induced rhinitis is defined as inflammation of the nasal passages leading to rhinorrhea, sneezing, congestion or nasal itching related to physical activity. Although abundant research exists regarding exercise induced asthma, urticaria, and anaphylaxis, as well as allergic rhinitis, little is understood regarding exercise induced rhinitis. Exercise induced rhinitis has been displayed in indoor and outdoor athletes with and without nasal allergy. Similarities exist between the nasal mucosa and the bronchial airways, suggesting similar mechanisms of inflammation between exercise induced asthma and rhinitis.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: M450 Source Type: research
The objectives of this article are to review the available literature regarding the geographic distribution of nettle, allergen(s) involved, cross-reactivity, role in allergic rhinitis, immunotherapy efficacy, and provide a clinical perspective on the evaluation and treatment of nettle sensitized patients.Recent findingsStinging nettle (Urtica dioica) is a bi-annual pollinator with worldwide distribution and wide use in homeopathy. Limited data suggest that nettle pollen allergens may be considered clinically relevant and that nettle pollen allergy may be underestimated. More recent allergomic analysis of nettle pollen has...
Source: Current Treatment Options in Allergy - Category: Allergy & Immunology Source Type: research
Conclusions: Allergic disease has a clear clinical association with IBS with more frequent and severe symptoms of IBS. CU patients have a tendency to suffer from IBS, usually with diarrhea. Serum total IgE and HDM-specific IgE are positively correlated with GI symptoms in atopic patients.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - Category: Allergy & Immunology Source Type: research
kman S, Can D Abstract Yazıcı S, Güneş S, Kurtuluş-Çokboz M, Kemer Ö, Baranlı G, Aşık-Akman S, Can D. Allergen variability and house dust mite sensitivity in pre-school children with allergic complaints. Turk J Pediatr 2018; 60: 41-49. The increase in the prevalence of allergic diseases in pre-school children who are often at home may be due to an increase in house dust mite sensitivity, which is rarely expected in this age group. In our study, it was aimed to investigate allergen sensitivities, especially house dust mite sensitivity in pre-school children with allergic disease complaints b...
Source: The Turkish Journal of Pediatrics - Category: Pediatrics Authors: Tags: Turk J Pediatr Source Type: research
Population histamine burden assessed using wastewater-based epidemiology: The association of 1,4‑methylimidazole acetic acid and fexofenadine. Environ Int. 2018 Aug 07;120:172-180 Authors: Choi PM, O'Brien JW, Li J, Jiang G, Thomas KV, Mueller JF Abstract Systematic sampling and analysis of wastewater has become an important tool for monitoring consumption of drugs and other substances, and has been proposed as a method to evaluate aspects of population health using endogenous biomarkers. 1,4‑methylimidazoleacetic acid (MIAA) is an endogenous biomarker and metabolite of histamine turnover. Its uri...
Source: Environment International - Category: Environmental Health Authors: Tags: Environ Int Source Type: research
Conclusion: Only a small number of our subjects were allergic to latex (7%) or rubber additives (4.8%). Thus, self-reported contact dermatoses (during NRL product use) in dental professionals and students are not commonly caused by allergies to latex and rubber additives, as is often assumed, but by other factors.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - Category: Allergy & Immunology Source Type: research
More News: Allergy | Allergy & Immunology | Complementary Medicine | Hay Fever | Hives | Homeopathy | Immunotherapy | Nettle | Study