Mast Cell Activation Syndromes and Environmental Exposures

Opinion statementMast cell activation syndromes (MCAS) are an emerging entity that includes a heterogeneous group of diseases presenting with typical signs and symptoms secondary to the release of mast cell (MC) mediators. Triggering factors underlying the activation of mast cells show a wide variability, and episodes of MC-mediator release are usually triggered by idiopathic or by mixed causes, which makes avoidance recommendations difficult to devise. Sometimes, environmental or occupational exposures are responsible for MC activation. In this article, we review the main workplace environment eliciting factors described in MCAS and the current guidance on treatment.
Source: Current Treatment Options in Allergy - Category: Allergy & Immunology Source Type: research