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Cancer Stem Cells in Carcinogenesis and Potential Role in Pancreatic Cancer
Curr Stem Cell Res Ther. 2023 Sep 14. doi: 10.2174/1574888X19666230914103420. Online ahead of print.ABSTRACTA poor prognosis is associated with pancreatic cancer because of resistance during treatment and early distant metastases. The discovery of cancer stem cells has opened up novel avenues for research into the biology and treatment of cancer. Many investigations have pointed out the role of these types of stem cells in the oncogenesis and progression of hematologic and solid malignancies, specifically. Due to the existence of cancer stem cells in the proliferation and preservation of pancreatic tumors, such malignancie...
Source: Current Stem Cell Research and Therapy - September 15, 2023 Category: Stem Cells Authors: Rishav Sharma Rishabha Malviya Source Type: research

Comparative efficacy of endogenous stem cells recruiting hydrogels and stem cell-loaded hydrogels in knee cartilage regeneration: a meta-analysis
Conclusion The current study indicates that both endogenous stem cell recruiting hydrogels and stem cell loaded hydrogels can effectively promote knee joint cartilage regeneration in animal trials.PMID:37711133 | DOI:10.2174/1574888X19666230914123443 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - September 15, 2023 Category: Stem Cells Authors: Wanyun Feng Chaohua Zhu Ruoxiang Miao Danni Li Xi Xiong Ruyu Wang Guobing Liu Jun Ma Source Type: research

Secretome Derived from Mesenchymal Stem/Stromal Cells: A Promising Strategy for Diabetes and its Complications
Curr Stem Cell Res Ther. 2023 Sep 13. doi: 10.2174/1574888X19666230913154544. Online ahead of print.ABSTRACTDiabetes is a complex metabolic disease with a high global prevalence. The health and quality of life of patients with diabetes are threatened by many complications, including diabetic foot ulcers, diabetic kidney diseases, diabetic retinopathy, and diabetic peripheral neuropathy. The application of mesenchymal stem/stromal cells (MSCs) in cell therapies has been recognized as a potential treatment for diabetes and its complications. MSCs were originally thought to exert biological effects exclusively by differentiat...
Source: Current Stem Cell Research and Therapy - September 15, 2023 Category: Stem Cells Authors: Ling Li Siyu Hua Lianghui You Tianying Zhong Source Type: research

Advancements in autologous stem cell transplantation for Parkinson's Disease
Curr Stem Cell Res Ther. 2023 Sep 7. doi: 10.2174/1574888X19666230907112413. Online ahead of print.ABSTRACTParkinson's disease (PD) is a progressive neurodegenerative disease marked by comparatively focal dopaminergic neuron degeneration in the substantia nigra of the midbrain and dopamine loss in the striatum, which causes motor and non-motor symptoms. Currently, pharmacological therapy and deep brain stimulation(DBS) are the primary treatment modalities for PD in clinical practice. While these approaches offer temporary symptom control, they do not address the underlying neurodegenerative process, and complications often...
Source: Current Stem Cell Research and Therapy - September 11, 2023 Category: Stem Cells Authors: Jia-Xin Shi Ke-Zhong Zhang Source Type: research

Evaluation of The Composite Skin Patch Loaded with Bioactive Functional Factors Derived from Multicellular Spheres of EMSCs for Regeneration of Full-thickness Skin Defects in Rats
CONCLUSION: In summary, the bioactive functional composite skin patch containing EMSCs-CM lyophilized powder can effectively accelerate skin repair, which has promising application prospects in the treatment of skin defects.PMID:37694794 | DOI:10.2174/1574888X19666230908142426 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - September 11, 2023 Category: Stem Cells Authors: Xuan Zhang Wentao Shi Xun Wang Yin Zou Wen Xiang Naiyan Lu Source Type: research

Bone marrow mesenchymal stem cell extracellular vesicle-derived miR-27b-3p activates the Wnt/ β-catenin pathway by targeting SMAD4 and aggravates hepatic ischemia-reperfusion injury
CONCLUSION: Our findings revealed the role and mechanism of miR-27-3p in HIRI and provide novel insights for the prevention and treatment of HIRI; for example, EVs derived from BMSCs transfected with antimiR-27 might demonstrate better protection against HIRI.PMID:37680161 | DOI:10.2174/1574888X19666230901140628 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - September 8, 2023 Category: Stem Cells Authors: Hongnan Li Weidong Lin Yunlei Li Jiayang Zhang Runsheng Liu Minghai Qu Ruihua Wang Xiaomin Kang Xuekun Xing Source Type: research