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Construction of a Cancer Stem Cell related Histone Acetylation Regulatory Genes Prognostic Model for Hepatocellular Carcinoma via Bioinformatics Analysis: Implications for Tumor Chemotherapy and Immunity
CONCLUSION: This study constructed a mRNAsi and HAGs-related prognostic model, which has implications for potential immunotherapy and drug treatment of LIHC.PMID:38561604 | DOI:10.2174/011574888X305642240327041753 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - April 1, 2024 Category: Stem Cells Authors: Qian Dai Jie Zhu Jing Yang Chun-Yan Zhang Wen-Jing Yang Bai-Shen Pan Xin-Rong Yang Wei Guo Bei-Li Wang Source Type: research

Comparative Outcomes of Intravenous, Intranasal, and Intracerebroventricular Transplantation of Human Neural Stem Cells in Mice Model of Ischemic Stroke
CONCLUSION: IV and IN delivery is suitable for repeated administration of hNSCs to achieve improved prognosis. Comparatively, ICV transplantation provides long-term efficacy at lower doses and fewer administration times.PMID:38529606 | DOI:10.2174/011574888X290104240320041613 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - March 26, 2024 Category: Stem Cells Authors: Mengze Zhang Yaying Song Chong Xie Yangtai Guan Source Type: research

Potential Druggability of Mesenchymal Stem/Stromal Cell-derived Exosomes
Curr Stem Cell Res Ther. 2024 Mar 22. doi: 10.2174/011574888X311270240319084835. Online ahead of print.ABSTRACTExosomes secreted by mesenchymal stem/stromal cells (MSC-Exos) are advantageous candidate sources for novel acellular therapy. Despite the current standards of good manufacturing practice (GMP), the deficiency of suitable quality-control methods and the difficulties in large-scale preparation largely restrict the development of therapeutic products and their clinical applications worldwide. Herein, we mainly focus on three dominating issues commonly encountered in exosomal GMP, including issues upstream of the cel...
Source: Current Stem Cell Research and Therapy - March 25, 2024 Category: Stem Cells Authors: Fan Zhang Leisheng Zhang Hao Yu Source Type: research

Bone Marrow-derived Mesenchymal Stem Cell Therapy in Retinitis Pigmentosa
CONCLUSION: Retinitis pigmentosa is a progressive, inherited disease that can result in severe vision loss. In retinitis pigmentosa, the application of bone marrow-derived mesenchymal stem cells by deep subtenon injection has positive effects on visual function. No systemic or ophthalmic side effects were detected in the patients during the 6-month follow-up period.PMID:38504575 | DOI:10.2174/011574888X293265240311120103 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - March 20, 2024 Category: Stem Cells Authors: Nil Irem Ucgun Cenk Zeki Fikret Mualla Sahin Hamurcu Source Type: research

Conditioned Medium Treatment for the Improvement of Functional Recovery after Spinal Cord Injury: A Meta-Analysis Study
CONCLUSION: CM had a significant effect in improving motor function after SCI, especially in cases of mild lesions. It has been observed that if CM originates from the neural stem cells, it has a more significant effect than mesenchymal cells.PMID:38424429 | DOI:10.2174/011574888X283713240129095031 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - February 29, 2024 Category: Stem Cells Authors: Razieh Hajisoltani Mona Taghizadeh Michael R Hamblin Fatemeh Ramezani Source Type: research