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In-vitro Augmentation of Mesenchymal Stem Cells by Using Adult Bovine Serum
CONCLUSION: Intriguingly, ABS proved to be an effective supplement in the growth medium for expanding UC-MSCs in vitro, providing a viable alternative to FBS.PMID:37861050 | DOI:10.2174/011574888X260118230927050143 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - October 20, 2023 Category: Stem Cells Authors: Somia Shehzadi Maryam Javed Asmat Ullah Ahmad Bilal Waqar Fatima Iftikhar Shah Sajjad Ullah Source Type: research

Tumor Organoid as a Drug Screening Platform for Cancer Research
Curr Stem Cell Res Ther. 2023 Oct 6. doi: 10.2174/011574888X268366230922080423. Online ahead of print.ABSTRACTA number of studies have been conducted on the application of 3D models for drug discovery, drug sensitivity assessment, and drug toxicity. Most of these studies focused on disease modelling and attempted to control cellular differentiation, heterogeneity, and key physiological features to mimic organ reconstitution so that researchers could achieve an accurate response in drug evaluation. Recently, organoids have been used by various scientists due to their highly organotypic structure, which facilitates the trans...
Source: Current Stem Cell Research and Therapy - October 19, 2023 Category: Stem Cells Authors: Reyhaneh Mahbubi Niloufar Yousefi Amir Ali Hamidieh Fatemeh Gholizadeh Mahsa Mollapour Sisakht Source Type: research

Insight to Biofabrication of Liver Microtissues for Disease Modeling: Challenges and Opportunities
Curr Stem Cell Res Ther. 2023 Oct 13. doi: 10.2174/011574888X257744231009071810. Online ahead of print.ABSTRACTIn the last decade, liver diseases with high mortality rates have become one of the most important health problems in the world. Organ transplantation is currently considered the most effective treatment for compensatory liver failure. An increasing number of patients and shortage of donors has led to the attention of reconstructive medicine methods researchers. The biggest challenge in the development of drugs effective in chronic liver disease is the lack of a suitable preclinical model that can mimic the microe...
Source: Current Stem Cell Research and Therapy - October 17, 2023 Category: Stem Cells Authors: Hengameh Dortaj Negar Azarpira Sara Pakbaz Source Type: research

Mesenchymal Stem Cell-conditioned Medium Protecting Renal Tubular Epithelial Cells by Inhibiting Hypoxia-inducible Factor-1 α and Nuclear Receptor Coactivator-1
CONCLUSION: Our results suggest that MSC-CM has a protective effect on RTECs by down-regulating HIF-1α and NCoA-1, which may be the harmful factors in renal injury.PMID:37817516 | DOI:10.2174/011574888X247652230928064627 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - October 11, 2023 Category: Stem Cells Authors: Chunling Liao Wenjuan Weng Yiping Liu Yongda Lin Jiali Wang Tianbiao Zhou Source Type: research

Impact of Mesenchymal Stem Cells on the Gut Microbiota and Microbiota Associated Functions in Inflammatory Bowel Disease: A Systematic Review of Preclinical Evidence on Animal Models
CONCLUSION: Current data support the remodeling effect on gut microbiota with MSC administration, which provides a potential therapeutic mechanism for MSCs in the treatment of IBD. Additional studies in humans and animal models are warranted to further confirm the role of gut microflora in MSCs repairing IBD.PMID:37817517 | DOI:10.2174/011574888X250413230920051715 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - October 11, 2023 Category: Stem Cells Authors: Airu Liu Chenyang Li Chen Wang Xiaonan Liang Xiaolan Zhang Source Type: research

Adipose Stem Cells Derived Exosomes Alleviate Bronchopulmonary Dysplasia and Regulate Autophagy in Neonatal Rats
CONCLUSION: The intratracheal administration of ADSC-Exos significantly improved alveolarization and pulmonary vascularization arrest in hyperoxia-induced BPD, which was associated with facilitating autophagy in part.PMID:37817518 | DOI:10.2174/011574888X260261230928094309 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - October 11, 2023 Category: Stem Cells Authors: Yuanyuan Sun Cuie Chen Yuanyuan Liu Anqun Sheng Shi Wang Xixi Zhang Dan Wang Qiu Wang Chaosheng Lu Zhenlang Lin Source Type: research

Mesenchymal Stem Cell Transplantation in Type 1 Diabetes Treatment: Current Advances and Future Opportunity
Curr Stem Cell Res Ther. 2023 Oct 10. doi: 10.2174/011574888X268740231002054459. Online ahead of print.ABSTRACTType 1 Diabetes (T1D) is characterized by hyperglycemia, and caused by a lack of insulin secretion. At present there is no cure for T1D and patients are dependent on exogenous insulin for lifelong, which seriously affects their lives. Mesenchymal stem cells (MSCs) can be differentiated to β cell-like cells to rescue the secretion of insulin and reconstruct immunotolerance to preserve the function of islet β cells. Due to the higher proportion of children and adolescents in T1D patients, the efficacy and safety i...
Source: Current Stem Cell Research and Therapy - October 11, 2023 Category: Stem Cells Authors: Jie Liu Xin-Xing Wan Sheng-Yuan Zheng Hui-Hong He Md Asaduzzaman Khan Yu-Xing Feng Jing-Ge Xiao Yu Chen Xi-Min Hu Qi Zhang Kun Xiong Source Type: research

Cancer Stem Cells and Treatment of Cancer: An Update and Future Perspectives
This article concentrates on the development of novel therapeutic strategies that combine conventional treatments with CSC inhibitors to eradicate cancer cells and CSCs, thereby treating cancer and preventing its recurrence. However, the diversity of CSCs poses a significant obstacle to the development of CSC-targeted therapies, necessitating extensive research for a better understanding and exploration of therapeutic approaches. Future development of CSC-targeted therapies will rely heavily on overcoming this obstacle.PMID:37818567 | DOI:10.2174/011574888X247548230921063514 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - October 11, 2023 Category: Stem Cells Authors: Mudassir Khan Mashal Naeem Sana Aftab Chaudary Affan Ahmed Aftab Ahmed Source Type: research