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The Role of Mesenchymal Stem/Stromal Cells Secretome in Macrophage Polarization: Perspectives on Treating Inflammatory Diseases
Curr Stem Cell Res Ther. 2023 Sep 4. doi: 10.2174/1574888X18666230811093101. Online ahead of print.ABSTRACTMesenchymal stem/stromal cells (MSCs) have exhibited potential for treating multiple inflammation- related diseases (IRDs) due to their easy acquisition, unique immunomodulatory and tissue repair properties, and immune-privileged characteristics. It is worth mentioning that MSCs release a wide array of soluble bioactive components in the secretome that modulate host innate and adaptive immune responses and promote the resolution of inflammation. As the first line of defense, macrophages exist throughout the entire inf...
Source: Current Stem Cell Research and Therapy - September 19, 2023 Category: Stem Cells Authors: Dongdong Ti Jun Yi Huihua Chen Haojie Hao Chunmeng Shi Source Type: research

Mesenchymal Stem Cell-Derived Exosomes Mitigate Acute Murine Liver Injury via Ets-1 and Heme Oxygenase-1 Up-regulation
CONCLUSION: Exosome therapy activates the JNK signaling activation pathway as well as up-regulates Ets-1 and HO-1 expression, thereby protecting hepatocytes against hepatotoxin-induced cell death.PMID:37723631 | DOI:10.2174/1574888X19666230918102826 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - September 19, 2023 Category: Stem Cells Authors: Ying-Hsien Kao Chih-Yang Chang Yu-Chun Lin Po-Han Chen Po-Huang Lee Huoy-Rou Chang Wen-Yu Chang Yo-Chen Chang Shen-Fa Wun Cheuk-Kwan Sun Source Type: research

Cancer Stem Cells in Carcinogenesis and Potential Role in Pancreatic Cancer
Curr Stem Cell Res Ther. 2023 Sep 14. doi: 10.2174/1574888X19666230914103420. Online ahead of print.ABSTRACTA poor prognosis is associated with pancreatic cancer because of resistance during treatment and early distant metastases. The discovery of cancer stem cells has opened up novel avenues for research into the biology and treatment of cancer. Many investigations have pointed out the role of these types of stem cells in the oncogenesis and progression of hematologic and solid malignancies, specifically. Due to the existence of cancer stem cells in the proliferation and preservation of pancreatic tumors, such malignancie...
Source: Current Stem Cell Research and Therapy - September 15, 2023 Category: Stem Cells Authors: Rishav Sharma Rishabha Malviya Source Type: research

Comparative efficacy of endogenous stem cells recruiting hydrogels and stem cell-loaded hydrogels in knee cartilage regeneration: a meta-analysis
Conclusion The current study indicates that both endogenous stem cell recruiting hydrogels and stem cell loaded hydrogels can effectively promote knee joint cartilage regeneration in animal trials.PMID:37711133 | DOI:10.2174/1574888X19666230914123443 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - September 15, 2023 Category: Stem Cells Authors: Wanyun Feng Chaohua Zhu Ruoxiang Miao Danni Li Xi Xiong Ruyu Wang Guobing Liu Jun Ma Source Type: research

Secretome Derived from Mesenchymal Stem/Stromal Cells: A Promising Strategy for Diabetes and its Complications
Curr Stem Cell Res Ther. 2023 Sep 13. doi: 10.2174/1574888X19666230913154544. Online ahead of print.ABSTRACTDiabetes is a complex metabolic disease with a high global prevalence. The health and quality of life of patients with diabetes are threatened by many complications, including diabetic foot ulcers, diabetic kidney diseases, diabetic retinopathy, and diabetic peripheral neuropathy. The application of mesenchymal stem/stromal cells (MSCs) in cell therapies has been recognized as a potential treatment for diabetes and its complications. MSCs were originally thought to exert biological effects exclusively by differentiat...
Source: Current Stem Cell Research and Therapy - September 15, 2023 Category: Stem Cells Authors: Ling Li Siyu Hua Lianghui You Tianying Zhong Source Type: research