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Fucoxanthin Enhances the Antifibrotic Potential of Placenta-derived Mesenchymal Stem Cells in a CCl4-induced Mouse Model of Liver Fibrosis
CONCLUSION: Fx enhanced the therapeutic potential of PD-MSCs in CCl4-induced liver fibrosis, but more investigations are necessary to understand the mutual impact of PD-MSCs and Fx.PMID:38204245 | DOI:10.2174/011574888X279940231206100902 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - January 11, 2024 Category: Stem Cells Authors: Vasilii Slautin Konstantin Konyshev Ilya Gavrilov Olga Beresneva Irina Maklakova Dmitry Grebnev Source Type: research

Human Adipose-derived Stem Cells Upregulate IGF-1 and Alleviate Osteoarthritis in a Two-stage Rabbit Osteoarthritis Model
CONCLUSIONS: Our data suggest that hADSC transplantation promotes articular cartilage healing in the double-damage rabbit osteoarthritis model, IGF-1 may play an essential role in the hADSC-based cartilage repair process. Transplantation of hADSCs may be suitable for clinical application in the treatment of osteoarthritis.PMID:38192148 | DOI:10.2174/011574888X274359231122064109 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - January 9, 2024 Category: Stem Cells Authors: Juan Wang Shibo Su Chuanming Dong Qiang Fan Jishu Sun Siqing Liang Zuhuo Qin Chuqing Ma Jianfeng Jin Hongwen Zhu Tongmeng Jiang Jun Xu Source Type: research

Mesenchymal Stem Cells Target Gastric Cancer and Deliver Epirubicin via Tunneling Nanotubes for Enhanced Chemotherapy
CONCLUSIONS: We identified a novel approach for precisely targeting epirubicin release in gastric cancer cells. Therefore, mesenchymal stem cell-tunneling nanotubes could serve as a potential tool for targeted delivery of drugs, enhancing their chemotherapeutic effects in cancer cells.PMID:38173205 | DOI:10.2174/011574888X287102240101060146 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - January 4, 2024 Category: Stem Cells Authors: Yali Zhou Yumin Li Haibin Wang Haolin Sun Jing Su Yaqiong Fan Wei Xing Jie Fu Source Type: research

Human Umbilical Cord Mesenchymal Stem Cells Alleviate Chronic Salpingitis by Modulating Macrophage-Associated Inflammatory Factors
CONCLUSION: These results suggest that macrophage function may be related to the immune-modulating characteristics of hucMSCs that contribute to CS.PMID:38173206 | DOI:10.2174/011574888X261128231108043931 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - January 4, 2024 Category: Stem Cells Authors: Wenjuan Liao Xiaomao Li Xinrang Tang Source Type: research

Regulation of ROS/inflammasome Axis is Essential for Cardiac Regeneration in Aging Rats Receiving Transplantation of Mesenchymal Stem Cells
CONCLUSION: These findings suggest that mesenchymal stem cell transplantation effectively ameliorates aging hearts through oxidative stress/inflammasome axis regulation. The results from this study provide clinical potential for stem cell-based therapy in the treatment of aging hearts.PMID:38031779 | DOI:10.2174/011574888X276612231121065203 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - November 30, 2023 Category: Stem Cells Authors: Wei-Syun Hu Jing-Yi Chen Wei-Yu Liao Chin-Hsien Chang Tung-Sheng Chen Source Type: research