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Mesenchymal Stem Cell-conditioned Medium Protecting Renal Tubular Epithelial Cells by Inhibiting Hypoxia-inducible Factor-1 α and Nuclear Receptor Coactivator-1
CONCLUSION: Our results suggest that MSC-CM has a protective effect on RTECs by down-regulating HIF-1α and NCoA-1, which may be the harmful factors in renal injury.PMID:37817516 | DOI:10.2174/011574888X247652230928064627 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - October 11, 2023 Category: Stem Cells Authors: Chunling Liao Wenjuan Weng Yiping Liu Yongda Lin Jiali Wang Tianbiao Zhou Source Type: research

Impact of Mesenchymal Stem Cells on the Gut Microbiota and Microbiota Associated Functions in Inflammatory Bowel Disease: A Systematic Review of Preclinical Evidence on Animal Models
CONCLUSION: Current data support the remodeling effect on gut microbiota with MSC administration, which provides a potential therapeutic mechanism for MSCs in the treatment of IBD. Additional studies in humans and animal models are warranted to further confirm the role of gut microflora in MSCs repairing IBD.PMID:37817517 | DOI:10.2174/011574888X250413230920051715 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - October 11, 2023 Category: Stem Cells Authors: Airu Liu Chenyang Li Chen Wang Xiaonan Liang Xiaolan Zhang Source Type: research

Adipose Stem Cells Derived Exosomes Alleviate Bronchopulmonary Dysplasia and Regulate Autophagy in Neonatal Rats
CONCLUSION: The intratracheal administration of ADSC-Exos significantly improved alveolarization and pulmonary vascularization arrest in hyperoxia-induced BPD, which was associated with facilitating autophagy in part.PMID:37817518 | DOI:10.2174/011574888X260261230928094309 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - October 11, 2023 Category: Stem Cells Authors: Yuanyuan Sun Cuie Chen Yuanyuan Liu Anqun Sheng Shi Wang Xixi Zhang Dan Wang Qiu Wang Chaosheng Lu Zhenlang Lin Source Type: research

Mesenchymal Stem Cell Transplantation in Type 1 Diabetes Treatment: Current Advances and Future Opportunity
Curr Stem Cell Res Ther. 2023 Oct 10. doi: 10.2174/011574888X268740231002054459. Online ahead of print.ABSTRACTType 1 Diabetes (T1D) is characterized by hyperglycemia, and caused by a lack of insulin secretion. At present there is no cure for T1D and patients are dependent on exogenous insulin for lifelong, which seriously affects their lives. Mesenchymal stem cells (MSCs) can be differentiated to β cell-like cells to rescue the secretion of insulin and reconstruct immunotolerance to preserve the function of islet β cells. Due to the higher proportion of children and adolescents in T1D patients, the efficacy and safety i...
Source: Current Stem Cell Research and Therapy - October 11, 2023 Category: Stem Cells Authors: Jie Liu Xin-Xing Wan Sheng-Yuan Zheng Hui-Hong He Md Asaduzzaman Khan Yu-Xing Feng Jing-Ge Xiao Yu Chen Xi-Min Hu Qi Zhang Kun Xiong Source Type: research

Cancer Stem Cells and Treatment of Cancer: An Update and Future Perspectives
This article concentrates on the development of novel therapeutic strategies that combine conventional treatments with CSC inhibitors to eradicate cancer cells and CSCs, thereby treating cancer and preventing its recurrence. However, the diversity of CSCs poses a significant obstacle to the development of CSC-targeted therapies, necessitating extensive research for a better understanding and exploration of therapeutic approaches. Future development of CSC-targeted therapies will rely heavily on overcoming this obstacle.PMID:37818567 | DOI:10.2174/011574888X247548230921063514 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - October 11, 2023 Category: Stem Cells Authors: Mudassir Khan Mashal Naeem Sana Aftab Chaudary Affan Ahmed Aftab Ahmed Source Type: research

Clinical Trials of Mesenchymal Stem Cells for the Treatment of COVID 19
Curr Stem Cell Res Ther. 2023 Oct 5. doi: 10.2174/011574888X260032230925052240. Online ahead of print.ABSTRACTMesenchymal Stem Cells (MSCs) are being investigated as a treatment for a novel viral disease owing to their immunomodulatory, anti-inflammatory, tissue repair and regeneration characteristics, however, the exact processes are unknown. MSC therapy was found to be effective in lowering immune system overactivation and increasing endogenous healing after SARS-CoV-2 infection by improving the pulmonary microenvironment. Many studies on mesenchymal stem cells have been undertaken concurrently, and we may help speed up ...
Source: Current Stem Cell Research and Therapy - October 10, 2023 Category: Stem Cells Authors: Elham Zendedel Lobat Tayebi Mohammad Nikbakht Elham Hasanzadeh Shiva Asadpour Source Type: research

The Effect of Mesenchymal Stem Cells on Wound Infection
Curr Stem Cell Res Ther. 2023 Oct 5. doi: 10.2174/011574888X252482230926104342. Online ahead of print.ABSTRACTWound infection often requires a long period of care and an onerous treatment process. Also, the rich environment makes the wound an ideal niche for microbial growth. Stable structures, like biofilm, and drug-resistant strains cause a delay in the healing process, which has become one of the important challenges in wound treatment. Many studies have focused on alternative methods to deal the wound infections. One of the novel and highly potential ways is mesenchymal stromal cells (MSCs). MSCs are mesoderm-derived p...
Source: Current Stem Cell Research and Therapy - October 10, 2023 Category: Stem Cells Authors: Mansoor Khaledi Bita Zandi Zeinab Mohsenipour Source Type: research

Progress of Cancer Stem Cells in Retinoblastoma
This article aims to review the relevant research and explore future development direction.PMID:37815190 | DOI:10.2174/011574888X252989230921065809 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - October 10, 2023 Category: Stem Cells Authors: Nan Wang Jian-Min Ma Source Type: research

Advancements in Biotechnology and Stem Cell Therapies for Breast Cancer Patients
Curr Stem Cell Res Ther. 2023 Oct 5. doi: 10.2174/011574888X268109230924233850. Online ahead of print.ABSTRACTThis comprehensive review article examines the integration of biotechnology and stem cell therapy in breast cancer diagnosis and treatment. It discusses the use of biotechnological tools such as liquid biopsies, genomic profiling, and imaging technologies for accurate diagnosis and monitoring of treatment response. Stem cell-based approaches, their role in modeling breast cancer progression, and their potential for breast reconstruction post-mastectomy are explored. The review highlights the importance of personali...
Source: Current Stem Cell Research and Therapy - October 10, 2023 Category: Stem Cells Authors: Shivang Dhoundiyal Prof Dr Md Aftab Alam Source Type: research

Generating Retinas through Guided Pluripotent Stem Cell Differentiation and Direct Somatic Cell Reprogramming
Curr Stem Cell Res Ther. 2023 Oct 2. doi: 10.2174/011574888X255496230923164547. Online ahead of print.ABSTRACTRetinal degeneration diseases affect millions of people worldwide but are among the most difficult eye diseases to cure. Studying the mechanisms and developing new therapies for these blinding diseases requires researchers to have access to many retinal cells. In recent years there has been substantial advances in the field of biotechnology in generating retinal cells and even tissues in vitro, either through programmed sequential stem cell differentiation or direct somatic cell lineage reprogramming. The resemblan...
Source: Current Stem Cell Research and Therapy - October 9, 2023 Category: Stem Cells Authors: Ke Zhang Wenwen Cai Leyi Hu Shuyi Chen Source Type: research

Therapeutic and Safety Promise of Mesenchymal Stem Cells for Liver Failure: from Preclinical Experiment to Clinical Application
Curr Stem Cell Res Ther. 2023 Oct 3. doi: 10.2174/011574888X260690230921174343. Online ahead of print.ABSTRACTLiver failure (LF) is serious liver damage caused by multiple factors, resulting in severe impairment or decompensation of liver synthesis, detoxification, metabolism, and biotransformation. The general prognosis of LF is poor with high mortality in non-transplant patients. The clinical treatments for LF are mainly internal medicine comprehensive care, an artificial liver support system, and liver transplantation. However, none of the above treatment strategies can solve the problems of all liver failure patients a...
Source: Current Stem Cell Research and Therapy - October 9, 2023 Category: Stem Cells Authors: Qiong Xie Jundong Gu Source Type: research

Adipose Mesenchymal Stem Cell-derived Exosomes Enhanced Glycolysis through the SIX1/HBO1 Pathway against Oxygen and Glucose Deprivation Injury in Human Umbilical Vein Endothelial Cells
CONCLUSION: The current study findings demonstrate a useful angiogenic therapeutic strategy for AMSC-exos treatment in vascular injury, thus providing new therapeutic ideas for treating ischaemic diseases.PMID:37779410 | DOI:10.2174/011574888X265623230921045240 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - October 2, 2023 Category: Stem Cells Authors: Xiangyu Zhang Xin Zhang Lu Chen Jiaqi Zhao Ashok Raj Yanping Wang Shulin Li Chi Zhang Jing Yang Dong Sun Source Type: research