Bone marrow mesenchymal stem cell extracellular vesicle-derived miR-27b-3p activates the Wnt/ β-catenin pathway by targeting SMAD4 and aggravates hepatic ischemia-reperfusion injury
CONCLUSION: Our findings revealed the role and mechanism of miR-27-3p in HIRI and provide novel insights for the prevention and treatment of HIRI; for example, EVs derived from BMSCs transfected with antimiR-27 might demonstrate better protection against HIRI.PMID:37680161 | DOI:10.2174/1574888X19666230901140628 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - September 8, 2023 Category: Stem Cells Authors: Hongnan Li Weidong Lin Yunlei Li Jiayang Zhang Runsheng Liu Minghai Qu Ruihua Wang Xiaomin Kang Xuekun Xing Source Type: research

Characterization of Central and Nasal Orbital Adipose Stem Cells and their Neural Differentiation Footprints
CONCLUSION: We suggested the explant method of culture as an easy and suitable method for the expansion of OASCs. Our findings denote mesenchymal properties of both central and nasal OASCs, while mesenchymal and neural characteristics were expressed stronger in nasal OASCs when compared to central ones. These findings can be added to the literature when cell transplantation is targeted in the treatment of neuro-retinal degenerative disorders.PMID:37670706 | DOI:10.2174/1574888X19666230905114246 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - September 6, 2023 Category: Stem Cells Authors: Fatemeh Sanie-Jahromi M Hossein Nowroozzadeh Mina Shaabanian Behzad Khademi Naser Owji Davood Mehrabani Source Type: research

Characterization of Central and Nasal Orbital Adipose Stem Cells and their Neural Differentiation Footprints
CONCLUSION: We suggested the explant method of culture as an easy and suitable method for the expansion of OASCs. Our findings denote mesenchymal properties of both central and nasal OASCs, while mesenchymal and neural characteristics were expressed stronger in nasal OASCs when compared to central ones. These findings can be added to the literature when cell transplantation is targeted in the treatment of neuro-retinal degenerative disorders.PMID:37670706 | DOI:10.2174/1574888X19666230905114246 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - September 6, 2023 Category: Stem Cells Authors: Fatemeh Sanie-Jahromi M Hossein Nowroozzadeh Mina Shaabanian Behzad Khademi Naser Owji Davood Mehrabani Source Type: research

Interferon-gamma treatment of human umbilical cord mesenchymal stem cells can significantly reduce damage associated with diabetic peripheral neuropathy in mice
CONCLUSION: Interferon-gamma treatment of umbilical cord mesenchymal stem cells enhanced osteogenic differentiation, adipogenic differentiation, and proliferative potential. It can enhance the ability of human umbilical cord mesenchymal stem cells to alleviate damage to diabetic nerve fibers and Schwann cells, in addition to improving the neurological function of diabetic mice.PMID:37644749 | DOI:10.2174/1574888X19666230829155046 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - August 30, 2023 Category: Stem Cells Authors: Li-Fen Yang Jun-Dong He Wei-Qi Jiang Xiao-Dan Wang Xiao-Chun Yang Zhi Liang Yi-Kun Zhou Source Type: research

Interferon-gamma treatment of human umbilical cord mesenchymal stem cells can significantly reduce damage associated with diabetic peripheral neuropathy in mice
CONCLUSION: Interferon-gamma treatment of umbilical cord mesenchymal stem cells enhanced osteogenic differentiation, adipogenic differentiation, and proliferative potential. It can enhance the ability of human umbilical cord mesenchymal stem cells to alleviate damage to diabetic nerve fibers and Schwann cells, in addition to improving the neurological function of diabetic mice.PMID:37644749 | DOI:10.2174/1574888X19666230829155046 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - August 30, 2023 Category: Stem Cells Authors: Li-Fen Yang Jun-Dong He Wei-Qi Jiang Xiao-Dan Wang Xiao-Chun Yang Zhi Liang Yi-Kun Zhou Source Type: research