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Adipose Mesenchymal Stem Cell-derived Exosomes Enhanced Glycolysis through the SIX1/HBO1 Pathway against Oxygen and Glucose Deprivation Injury in Human Umbilical Vein Endothelial Cells
CONCLUSION: The current study findings demonstrate a useful angiogenic therapeutic strategy for AMSC-exos treatment in vascular injury, thus providing new therapeutic ideas for treating ischaemic diseases.PMID:37779410 | DOI:10.2174/011574888X265623230921045240 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - October 2, 2023 Category: Stem Cells Authors: Xiangyu Zhang Xin Zhang Lu Chen Jiaqi Zhao Ashok Raj Yanping Wang Shulin Li Chi Zhang Jing Yang Dong Sun Source Type: research

Mesenchymal Stem Cell-Derived Exosomes Mitigate Acute Murine Liver Injury via Ets-1 and Heme Oxygenase-1 Up-regulation
CONCLUSION: Exosome therapy activates the JNK signaling activation pathway as well as up-regulates Ets-1 and HO-1 expression, thereby protecting hepatocytes against hepatotoxin-induced cell death.PMID:37723631 | DOI:10.2174/1574888X19666230918102826 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - September 19, 2023 Category: Stem Cells Authors: Ying-Hsien Kao Chih-Yang Chang Yu-Chun Lin Po-Han Chen Po-Huang Lee Huoy-Rou Chang Wen-Yu Chang Yo-Chen Chang Shen-Fa Wun Cheuk-Kwan Sun Source Type: research

The Role of Mesenchymal Stem/Stromal Cells Secretome in Macrophage Polarization: Perspectives on Treating Inflammatory Diseases
Curr Stem Cell Res Ther. 2023 Sep 4. doi: 10.2174/1574888X18666230811093101. Online ahead of print.ABSTRACTMesenchymal stem/stromal cells (MSCs) have exhibited potential for treating multiple inflammation- related diseases (IRDs) due to their easy acquisition, unique immunomodulatory and tissue repair properties, and immune-privileged characteristics. It is worth mentioning that MSCs release a wide array of soluble bioactive components in the secretome that modulate host innate and adaptive immune responses and promote the resolution of inflammation. As the first line of defense, macrophages exist throughout the entire inf...
Source: Current Stem Cell Research and Therapy - September 19, 2023 Category: Stem Cells Authors: Dongdong Ti Jun Yi Huihua Chen Haojie Hao Chunmeng Shi Source Type: research