Bone marrow mesenchymal stem cell extracellular vesicle-derived miR-27b-3p activates the Wnt/ β-catenin pathway by targeting SMAD4 and aggravates hepatic ischemia-reperfusion injury

CONCLUSION: Our findings revealed the role and mechanism of miR-27-3p in HIRI and provide novel insights for the prevention and treatment of HIRI; for example, EVs derived from BMSCs transfected with antimiR-27 might demonstrate better protection against HIRI.PMID:37680161 | DOI:10.2174/1574888X19666230901140628
Source: Current Stem Cell Research and Therapy - Category: Stem Cells Authors: Source Type: research