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Human blastoid as an in vitro model of human blastocysts
Curr Opin Genet Dev. 2023 Dec 4;84:102135. doi: 10.1016/j.gde.2023.102135. Online ahead of print.ABSTRACTHuman development is a highly coordinated process, with any abnormalities during the early embryonic stages that can often have detrimental consequences. The complexity and nuances of human development underpin its significance in embryo research. However, this research is often hindered by limited availability and ethical considerations associated with the use of donated blastocysts from in vitro fertilization (IVF) surplus. Human blastoids offer promising alternatives as they can be easily generated and manipulated in...
Source: Current Opinion in Genetics and Development - December 5, 2023 Category: Genetics & Stem Cells Authors: Xiaodong Liu Jose M Polo Source Type: research

Topical section: embryonic models (2023) for Current Opinion in Genetics & amp; Development
Curr Opin Genet Dev. 2023 Dec 4;84:102134. doi: 10.1016/j.gde.2023.102134. Online ahead of print.ABSTRACTStem cell-based mammalian embryo models facilitate the discovery of developmental mechanisms because they are more amenable to genetic and epigenetic perturbations than natural embryos. Here, we highlight exciting recent advances that have yielded a plethora of models of embryonic development. Imperfections in these models highlight gaps in our current understanding and outline future research directions, ushering in an exciting new era for embryology.PMID:38052116 | DOI:10.1016/j.gde.2023.102134 (Source: Current Opinio...
Source: Current Opinion in Genetics and Development - December 5, 2023 Category: Genetics & Stem Cells Authors: Charlotte E Handford Sergi Junyent Victoria Jorgensen Magdalena Zernicka-Goetz Source Type: research

'Enhancing' skeletal muscle and stem cells in three-dimensions: genome regulation of skeletal muscle in development and disease
Curr Opin Genet Dev. 2023 Dec;83:102133. doi: 10.1016/j.gde.2023.102133. Epub 2023 Nov 9.ABSTRACTThe noncoding genome imparts important regulatory control over gene expression. In particular, gene enhancers represent a critical layer of control that integrates developmental and differentiation signals outside the cell into transcriptional outputs inside the cell. Recently, there has been an explosion in genomic techniques to probe enhancer control, function, and regulation. How enhancers are regulated and integrate signals in stem cell development and differentiation is largely an open question. In this review, we focus on...
Source: Current Opinion in Genetics and Development - November 11, 2023 Category: Genetics & Stem Cells Authors: Matthew A Romero April D Pyle Source Type: research

'Enhancing' skeletal muscle and stem cells in three-dimensional: genome regulation of skeletal muscle in development and disease
Curr Opin Genet Dev. 2023 Nov 9;83:102133. doi: 10.1016/j.gde.2023.102133. Online ahead of print.ABSTRACTThe noncoding genome imparts important regulatory control over gene expression. In particular, gene enhancers represent a critical layer of control that integrates developmental and differentiation signals outside the cell into transcriptional outputs inside the cell. Recently, there has been an explosion in genomic techniques to probe enhancer control, function, and regulation. How enhancers are regulated and integrate signals in stem cell development and differentiation is largely an open question. In this review, we ...
Source: Current Opinion in Genetics and Development - November 11, 2023 Category: Genetics & Stem Cells Authors: Matthew A Romero April D Pyle Source Type: research