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'Enhancing' skeletal muscle and stem cells in three-dimensional: genome regulation of skeletal muscle in development and disease
Curr Opin Genet Dev. 2023 Nov 9;83:102133. doi: 10.1016/j.gde.2023.102133. Online ahead of print.ABSTRACTThe noncoding genome imparts important regulatory control over gene expression. In particular, gene enhancers represent a critical layer of control that integrates developmental and differentiation signals outside the cell into transcriptional outputs inside the cell. Recently, there has been an explosion in genomic techniques to probe enhancer control, function, and regulation. How enhancers are regulated and integrate signals in stem cell development and differentiation is largely an open question. In this review, we ...
Source: Current Opinion in Genetics and Development - November 11, 2023 Category: Genetics & Stem Cells Authors: Matthew A Romero April D Pyle Source Type: research

'Enhancing' skeletal muscle and stem cells in three-dimensional: genome regulation of skeletal muscle in development and disease
Curr Opin Genet Dev. 2023 Nov 9;83:102133. doi: 10.1016/j.gde.2023.102133. Online ahead of print.ABSTRACTThe noncoding genome imparts important regulatory control over gene expression. In particular, gene enhancers represent a critical layer of control that integrates developmental and differentiation signals outside the cell into transcriptional outputs inside the cell. Recently, there has been an explosion in genomic techniques to probe enhancer control, function, and regulation. How enhancers are regulated and integrate signals in stem cell development and differentiation is largely an open question. In this review, we ...
Source: Current Opinion in Genetics and Development - November 11, 2023 Category: Genetics & Stem Cells Authors: Matthew A Romero April D Pyle Source Type: research

'Enhancing' skeletal muscle and stem cells in three-dimensional: genome regulation of skeletal muscle in development and disease
Curr Opin Genet Dev. 2023 Nov 9;83:102133. doi: 10.1016/j.gde.2023.102133. Online ahead of print.ABSTRACTThe noncoding genome imparts important regulatory control over gene expression. In particular, gene enhancers represent a critical layer of control that integrates developmental and differentiation signals outside the cell into transcriptional outputs inside the cell. Recently, there has been an explosion in genomic techniques to probe enhancer control, function, and regulation. How enhancers are regulated and integrate signals in stem cell development and differentiation is largely an open question. In this review, we ...
Source: Current Opinion in Genetics and Development - November 11, 2023 Category: Genetics & Stem Cells Authors: Matthew A Romero April D Pyle Source Type: research

'Enhancing' skeletal muscle and stem cells in three-dimensional: genome regulation of skeletal muscle in development and disease
Curr Opin Genet Dev. 2023 Nov 9;83:102133. doi: 10.1016/j.gde.2023.102133. Online ahead of print.ABSTRACTThe noncoding genome imparts important regulatory control over gene expression. In particular, gene enhancers represent a critical layer of control that integrates developmental and differentiation signals outside the cell into transcriptional outputs inside the cell. Recently, there has been an explosion in genomic techniques to probe enhancer control, function, and regulation. How enhancers are regulated and integrate signals in stem cell development and differentiation is largely an open question. In this review, we ...
Source: Current Opinion in Genetics and Development - November 11, 2023 Category: Genetics & Stem Cells Authors: Matthew A Romero April D Pyle Source Type: research

'Enhancing' skeletal muscle and stem cells in three-dimensional: genome regulation of skeletal muscle in development and disease
Curr Opin Genet Dev. 2023 Nov 9;83:102133. doi: 10.1016/j.gde.2023.102133. Online ahead of print.ABSTRACTThe noncoding genome imparts important regulatory control over gene expression. In particular, gene enhancers represent a critical layer of control that integrates developmental and differentiation signals outside the cell into transcriptional outputs inside the cell. Recently, there has been an explosion in genomic techniques to probe enhancer control, function, and regulation. How enhancers are regulated and integrate signals in stem cell development and differentiation is largely an open question. In this review, we ...
Source: Current Opinion in Genetics and Development - November 11, 2023 Category: Genetics & Stem Cells Authors: Matthew A Romero April D Pyle Source Type: research

'Enhancing' skeletal muscle and stem cells in three-dimensional: genome regulation of skeletal muscle in development and disease
Curr Opin Genet Dev. 2023 Nov 9;83:102133. doi: 10.1016/j.gde.2023.102133. Online ahead of print.ABSTRACTThe noncoding genome imparts important regulatory control over gene expression. In particular, gene enhancers represent a critical layer of control that integrates developmental and differentiation signals outside the cell into transcriptional outputs inside the cell. Recently, there has been an explosion in genomic techniques to probe enhancer control, function, and regulation. How enhancers are regulated and integrate signals in stem cell development and differentiation is largely an open question. In this review, we ...
Source: Current Opinion in Genetics and Development - November 11, 2023 Category: Genetics & Stem Cells Authors: Matthew A Romero April D Pyle Source Type: research

'Enhancing' skeletal muscle and stem cells in three-dimensional: genome regulation of skeletal muscle in development and disease
Curr Opin Genet Dev. 2023 Nov 9;83:102133. doi: 10.1016/j.gde.2023.102133. Online ahead of print.ABSTRACTThe noncoding genome imparts important regulatory control over gene expression. In particular, gene enhancers represent a critical layer of control that integrates developmental and differentiation signals outside the cell into transcriptional outputs inside the cell. Recently, there has been an explosion in genomic techniques to probe enhancer control, function, and regulation. How enhancers are regulated and integrate signals in stem cell development and differentiation is largely an open question. In this review, we ...
Source: Current Opinion in Genetics and Development - November 11, 2023 Category: Genetics & Stem Cells Authors: Matthew A Romero April D Pyle Source Type: research

Somatic mutation burden in relation to aging and functional life span: implications for cellular reprogramming and rejuvenation
Curr Opin Genet Dev. 2023 Nov 4;83:102132. doi: 10.1016/j.gde.2023.102132. Online ahead of print.ABSTRACTThe accrual of somatic mutations has been implicated as causal factors in aging since the 1950s. However, the quantitative analysis of somatic mutations has posed a major challenge due to the random nature of de novo mutations in normal tissues, which has limited analysis to tumors and other clonal lineages. Advances in single-cell and single-molecule next-generation sequencing now allow to obtain, for the first time, detailed insights into the landscape of somatic mutations in different human tissues and cell types as ...
Source: Current Opinion in Genetics and Development - November 6, 2023 Category: Genetics & Stem Cells Authors: Alexander Y Maslov Jan Vijg Source Type: research

Somatic mutation burden in relation to aging and functional life span: implications for cellular reprogramming and rejuvenation
Curr Opin Genet Dev. 2023 Nov 4;83:102132. doi: 10.1016/j.gde.2023.102132. Online ahead of print.ABSTRACTThe accrual of somatic mutations has been implicated as causal factors in aging since the 1950s. However, the quantitative analysis of somatic mutations has posed a major challenge due to the random nature of de novo mutations in normal tissues, which has limited analysis to tumors and other clonal lineages. Advances in single-cell and single-molecule next-generation sequencing now allow to obtain, for the first time, detailed insights into the landscape of somatic mutations in different human tissues and cell types as ...
Source: Current Opinion in Genetics and Development - November 6, 2023 Category: Genetics & Stem Cells Authors: Alexander Y Maslov Jan Vijg Source Type: research

Somatic mutation burden in relation to aging and functional life span: implications for cellular reprogramming and rejuvenation
Curr Opin Genet Dev. 2023 Nov 4;83:102132. doi: 10.1016/j.gde.2023.102132. Online ahead of print.ABSTRACTThe accrual of somatic mutations has been implicated as causal factors in aging since the 1950s. However, the quantitative analysis of somatic mutations has posed a major challenge due to the random nature of de novo mutations in normal tissues, which has limited analysis to tumors and other clonal lineages. Advances in single-cell and single-molecule next-generation sequencing now allow to obtain, for the first time, detailed insights into the landscape of somatic mutations in different human tissues and cell types as ...
Source: Current Opinion in Genetics and Development - November 6, 2023 Category: Genetics & Stem Cells Authors: Alexander Y Maslov Jan Vijg Source Type: research

Somatic mutation burden in relation to aging and functional life span: implications for cellular reprogramming and rejuvenation
Curr Opin Genet Dev. 2023 Nov 4;83:102132. doi: 10.1016/j.gde.2023.102132. Online ahead of print.ABSTRACTThe accrual of somatic mutations has been implicated as causal factors in aging since the 1950s. However, the quantitative analysis of somatic mutations has posed a major challenge due to the random nature of de novo mutations in normal tissues, which has limited analysis to tumors and other clonal lineages. Advances in single-cell and single-molecule next-generation sequencing now allow to obtain, for the first time, detailed insights into the landscape of somatic mutations in different human tissues and cell types as ...
Source: Current Opinion in Genetics and Development - November 6, 2023 Category: Genetics & Stem Cells Authors: Alexander Y Maslov Jan Vijg Source Type: research

Modifying gastruloids to dissect mechanisms of tissue-specific induction
Curr Opin Genet Dev. 2023 Oct 25;83:102130. doi: 10.1016/j.gde.2023.102130. Online ahead of print.ABSTRACTHow functional organisms arise from a single cell is a fundamental question in biology with direct relevance to understanding developmental defects and diseases. Dissecting developmental processes provides the basic, critical framework for understanding disease progression and treatment. Bottom-up approaches to recapitulate formation of various components of the embryo have been effective to probe symmetry-breaking, self-organisation, tissue patterning and morphogenesis. However, these studies have been mostly concerne...
Source: Current Opinion in Genetics and Development - October 28, 2023 Category: Genetics & Stem Cells Authors: David A Turner Jennifer Nichols Source Type: research

Modifying gastruloids to dissect mechanisms of tissue-specific induction
Curr Opin Genet Dev. 2023 Oct 25;83:102130. doi: 10.1016/j.gde.2023.102130. Online ahead of print.ABSTRACTHow functional organisms arise from a single cell is a fundamental question in biology with direct relevance to understanding developmental defects and diseases. Dissecting developmental processes provides the basic, critical framework for understanding disease progression and treatment. Bottom-up approaches to recapitulate formation of various components of the embryo have been effective to probe symmetry-breaking, self-organisation, tissue patterning and morphogenesis. However, these studies have been mostly concerne...
Source: Current Opinion in Genetics and Development - October 28, 2023 Category: Genetics & Stem Cells Authors: David A Turner Jennifer Nichols Source Type: research

Modifying gastruloids to dissect mechanisms of tissue-specific induction
Curr Opin Genet Dev. 2023 Oct 25;83:102130. doi: 10.1016/j.gde.2023.102130. Online ahead of print.ABSTRACTHow functional organisms arise from a single cell is a fundamental question in biology with direct relevance to understanding developmental defects and diseases. Dissecting developmental processes provides the basic, critical framework for understanding disease progression and treatment. Bottom-up approaches to recapitulate formation of various components of the embryo have been effective to probe symmetry-breaking, self-organisation, tissue patterning and morphogenesis. However, these studies have been mostly concerne...
Source: Current Opinion in Genetics and Development - October 28, 2023 Category: Genetics & Stem Cells Authors: David A Turner Jennifer Nichols Source Type: research

Modifying gastruloids to dissect mechanisms of tissue-specific induction
Curr Opin Genet Dev. 2023 Oct 25;83:102130. doi: 10.1016/j.gde.2023.102130. Online ahead of print.ABSTRACTHow functional organisms arise from a single cell is a fundamental question in biology with direct relevance to understanding developmental defects and diseases. Dissecting developmental processes provides the basic, critical framework for understanding disease progression and treatment. Bottom-up approaches to recapitulate formation of various components of the embryo have been effective to probe symmetry-breaking, self-organisation, tissue patterning and morphogenesis. However, these studies have been mostly concerne...
Source: Current Opinion in Genetics and Development - October 28, 2023 Category: Genetics & Stem Cells Authors: David A Turner Jennifer Nichols Source Type: research