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Editorial overview: Conflicts, conflicts everywhere
Curr Opin Genet Dev. 2023 Oct 20;83:102131. doi: 10.1016/j.gde.2023.102131. Online ahead of print.NO ABSTRACTPMID:37866057 | DOI:10.1016/j.gde.2023.102131 (Source: Current Opinion in Genetics and Development)
Source: Current Opinion in Genetics and Development - October 22, 2023 Category: Genetics & Stem Cells Authors: Harmit S Malik Judith E Mank Source Type: research

Divergent outcomes of genetic conflict on the UV sex chromosomes of Marchantia polymorpha and Ceratodon purpureus
Curr Opin Genet Dev. 2023 Oct 19;83:102129. doi: 10.1016/j.gde.2023.102129. Online ahead of print.ABSTRACTIn species with separate sexes, the genome must produce two distinct developmental programs. Sexually dimorphic development may be controlled by either sex-limited loci or biased expression of loci transmitted through both sexes. Variation in the gene content of sex-limited chromosomes demonstrates that eukaryotic species differ markedly in the roles of these two mechanisms in governing sexual dimorphism. The bryophyte model systems Marchantia polymorpha and Ceratodon purpureus provide a particularly striking contrast....
Source: Current Opinion in Genetics and Development - October 21, 2023 Category: Genetics & Stem Cells Authors: Stuart F McDaniel Source Type: research

Insights and applications of direct neuronal reprogramming
Curr Opin Genet Dev. 2023 Oct 18;83:102128. doi: 10.1016/j.gde.2023.102128. Online ahead of print.ABSTRACTDirect neuronal reprogramming converts somatic cells of a defined lineage into induced neuronal cells without going through a pluripotent intermediate. This approach not only provides access to the otherwise largely inaccessible cells of the brain for neuronal disease modeling, but also holds great promise for ultimately enabling neuronal cell replacement without the use of transplantation. To improve efficiency and specificity of direct neuronal reprogramming, much of the current efforts aim to understand the mechanis...
Source: Current Opinion in Genetics and Development - October 20, 2023 Category: Genetics & Stem Cells Authors: Katie Schaukowitch Justyna A Janas Marius Wernig Source Type: research

Overcoming muscle stem cell aging
Curr Opin Genet Dev. 2023 Oct 13;83:102127. doi: 10.1016/j.gde.2023.102127. Online ahead of print.ABSTRACTReduced muscle strength and mass is one of the hallmarks of physiological aging in humans and can result in severe impairment of the quality of life. In part this is caused by a functional loss of the highly specialized muscle stem cells (MuSCs), which in healthy conditions provide maintenance, growth, and regeneration. Recent progress in understanding of the stem cell niche and results from single cell technologies reveal exciting insights at unprecedented detail into MuSCs and muscle biology during aging. Here, we re...
Source: Current Opinion in Genetics and Development - October 15, 2023 Category: Genetics & Stem Cells Authors: Sebastian Memczak Juan Ci Belmonte Source Type: research

Using human pluripotent stem cells to dissect trophoblast development
Curr Opin Genet Dev. 2023 Oct 7;83:102126. doi: 10.1016/j.gde.2023.102126. Online ahead of print.ABSTRACTIn 2021, we showed that naive human pluripotent stem cells (PSCs) can differentiate into trophoblasts via trophectoderm (TE)-like cells. Since TE is a pre-implantation stage of trophoblasts constituting blastocysts, naive human PSCs are an invaluable tool for understanding the entire process of trophoblast development. It has been reported for many years that primed human PSCs can also differentiate into the trophoblast lineage. The in vitro differentiation of naive and primed human PSCs hints at the possibility that hu...
Source: Current Opinion in Genetics and Development - October 9, 2023 Category: Genetics & Stem Cells Authors: Daisuke Suzuki Kuan-Chun Lan Yasuhiro Takashima Source Type: research