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Polycomb repressive complex 2 accessory factors: rheostats for cell fate decision?
Curr Opin Genet Dev. 2023 Dec 12;84:102137. doi: 10.1016/j.gde.2023.102137. Online ahead of print.ABSTRACTEpigenetic reprogramming during development is key to cell identity and the activities of the Polycomb repressive complexes are vital for this process. We focus on polycomb repressive complex 2 (PRC2), which catalyzes H3K27me1/2/3 and safeguards cellular integrity by ensuring proper gene repression. Notably, various accessory factors associate with PRC2, strongly influencing cell fate decisions, and their deregulation contributes to various illnesses. Yet, the exact role of these factors during development and carcinog...
Source: Current Opinion in Genetics and Development - December 13, 2023 Category: Genetics & Stem Cells Authors: Hina Bharti Sungwook Han Han-Wen Chang Danny Reinberg Source Type: research

Human blastoid as an in vitro model of human blastocysts
Curr Opin Genet Dev. 2023 Dec 4;84:102135. doi: 10.1016/j.gde.2023.102135. Online ahead of print.ABSTRACTHuman development is a highly coordinated process, with any abnormalities during the early embryonic stages that can often have detrimental consequences. The complexity and nuances of human development underpin its significance in embryo research. However, this research is often hindered by limited availability and ethical considerations associated with the use of donated blastocysts from in vitro fertilization (IVF) surplus. Human blastoids offer promising alternatives as they can be easily generated and manipulated in...
Source: Current Opinion in Genetics and Development - December 5, 2023 Category: Genetics & Stem Cells Authors: Xiaodong Liu Jose M Polo Source Type: research

Topical section: embryonic models (2023) for Current Opinion in Genetics & amp; Development
Curr Opin Genet Dev. 2023 Dec 4;84:102134. doi: 10.1016/j.gde.2023.102134. Online ahead of print.ABSTRACTStem cell-based mammalian embryo models facilitate the discovery of developmental mechanisms because they are more amenable to genetic and epigenetic perturbations than natural embryos. Here, we highlight exciting recent advances that have yielded a plethora of models of embryonic development. Imperfections in these models highlight gaps in our current understanding and outline future research directions, ushering in an exciting new era for embryology.PMID:38052116 | DOI:10.1016/j.gde.2023.102134 (Source: Current Opinio...
Source: Current Opinion in Genetics and Development - December 5, 2023 Category: Genetics & Stem Cells Authors: Charlotte E Handford Sergi Junyent Victoria Jorgensen Magdalena Zernicka-Goetz Source Type: research