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Therapeutic targeting of BET bromodomain and other epigenetic acetylrecognition domain-containing factors
In conclusion, the potential for further development is discussed with a focus on proximity-based therapies targeting this class of epigenetic factors.PMID:38564841 | DOI:10.1016/j.gde.2024.102181 (Source: Current Opinion in Genetics and Development)
Source: Current Opinion in Genetics and Development - April 2, 2024 Category: Genetics & Stem Cells Authors: Sarah Gold Ali Shilatifard Source Type: research

Linking mitochondria metabolism, developmental timing, and human brain evolution
Curr Opin Genet Dev. 2024 Mar 30;86:102182. doi: 10.1016/j.gde.2024.102182. Online ahead of print.ABSTRACTChanges in developmental timing are an important factor of evolution in organ shape and function. This is particularly striking for human brain development, which, compared with other mammals, is considerably prolonged at the level of the cerebral cortex, resulting in brain neoteny. Here, we review recent findings that indicate that mitochondria and metabolism contribute to species differences in the tempo of cortical neuron development. Mitochondria display species-specific developmental timeline and metabolic activit...
Source: Current Opinion in Genetics and Development - March 31, 2024 Category: Genetics & Stem Cells Authors: Pierre Casimir Ryohei Iwata Pierre Vanderhaeghen Source Type: research

The significance of ultradian oscillations in development
Curr Opin Genet Dev. 2024 Mar 23;86:102180. doi: 10.1016/j.gde.2024.102180. Online ahead of print.ABSTRACTGenes regulating developmental processes have been identified, but the mechanisms underlying their expression with the correct timing are still under investigation. Several genes show oscillatory expression that regulates the timing of developmental processes, such as somitogenesis and neurogenesis. These oscillations are also important for other developmental processes, such as cell proliferation and differentiation. In this review, we discuss the significance of oscillatory gene expression in developmental time and o...
Source: Current Opinion in Genetics and Development - March 24, 2024 Category: Genetics & Stem Cells Authors: Yuki Maeda Ryoichiro Kageyama Source Type: research

RNA in chromatin organization and nuclear architecture
Curr Opin Genet Dev. 2024 Mar 14;86:102176. doi: 10.1016/j.gde.2024.102176. Online ahead of print.ABSTRACTIn the cell nucleus, genomic DNA is surrounded by nonmembranous nuclear bodies. This might result from specific regions of the genome being transcribed into long noncoding RNAs (lncRNAs), which tend to remain at the sites of their own transcription. The lncRNAs seed the nuclear bodies by recruiting and concentrating proteins and RNAs, which undergo liquid-liquid-phase separation, and form molecular condensates, the so-called nuclear bodies. These nuclear bodies may provide appropriate environments for gene activation o...
Source: Current Opinion in Genetics and Development - March 15, 2024 Category: Genetics & Stem Cells Authors: Maierdan Palihati Noriko Saitoh Source Type: research

Temporal patterning of the vertebrate developing neural tube
Curr Opin Genet Dev. 2024 Mar 14;86:102179. doi: 10.1016/j.gde.2024.102179. Online ahead of print.ABSTRACTThe chronologically ordered generation of distinct cell types is essential for the establishment of neuronal diversity and the formation of neuronal circuits. Recently, single-cell transcriptomic analyses of various areas of the developing vertebrate nervous system have provided evidence for the existence of a shared temporal patterning program that partitions neurons based on the timing of neurogenesis. In this review, I summarize the findings that lead to the proposal of this shared temporal program before focusing o...
Source: Current Opinion in Genetics and Development - March 15, 2024 Category: Genetics & Stem Cells Authors: Andreas Sagner Source Type: research