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RNA in chromatin organization and nuclear architecture
Curr Opin Genet Dev. 2024 Mar 14;86:102176. doi: 10.1016/j.gde.2024.102176. Online ahead of print.ABSTRACTIn the cell nucleus, genomic DNA is surrounded by nonmembranous nuclear bodies. This might result from specific regions of the genome being transcribed into long noncoding RNAs (lncRNAs), which tend to remain at the sites of their own transcription. The lncRNAs seed the nuclear bodies by recruiting and concentrating proteins and RNAs, which undergo liquid-liquid-phase separation, and form molecular condensates, the so-called nuclear bodies. These nuclear bodies may provide appropriate environments for gene activation o...
Source: Current Opinion in Genetics and Development - March 15, 2024 Category: Genetics & Stem Cells Authors: Maierdan Palihati Noriko Saitoh Source Type: research

Temporal patterning of the vertebrate developing neural tube
Curr Opin Genet Dev. 2024 Mar 14;86:102179. doi: 10.1016/j.gde.2024.102179. Online ahead of print.ABSTRACTThe chronologically ordered generation of distinct cell types is essential for the establishment of neuronal diversity and the formation of neuronal circuits. Recently, single-cell transcriptomic analyses of various areas of the developing vertebrate nervous system have provided evidence for the existence of a shared temporal patterning program that partitions neurons based on the timing of neurogenesis. In this review, I summarize the findings that lead to the proposal of this shared temporal program before focusing o...
Source: Current Opinion in Genetics and Development - March 15, 2024 Category: Genetics & Stem Cells Authors: Andreas Sagner Source Type: research

Dynamic microenvironments shape nuclear organization and gene expression
Curr Opin Genet Dev. 2024 Mar 9;86:102177. doi: 10.1016/j.gde.2024.102177. Online ahead of print.ABSTRACTLive imaging has revealed that the regulation of gene expression is largely driven by transient interactions. For example, many regulatory proteins bind chromatin for just seconds, and loop-like genomic contacts are rare and last only minutes. These discoveries have been difficult to reconcile with our canonical models that are predicated on stable and hierarchical interactions. Proteomic microenvironments that concentrate nuclear factors may explain how brief interactions can still mediate gene regulation by creating c...
Source: Current Opinion in Genetics and Development - March 10, 2024 Category: Genetics & Stem Cells Authors: Gabriela Hayward-Lara Matthew D Fischer Mustafa Mir Source Type: research