Genetic Appraisal of RAAS-Associated SNPs: REN (rs16853055), AGT (rs3789678) and ACE (rs4305) in Preeclamptic Women Living with HIV Infection
AbstractPurpose of ReviewThe primary goal of this review article was to determine whether the three RAAS-associated SNPs, Renin-rs16853055, AGT-rs3789678 and ACE-rs4305 are genetically linked to the development of hypertension in preeclampsia. The secondary goal was to establish if there was a link between these SNPs and HIV infection.Recent FindingsThere is a paucity of findings related to the aforementioned SNPs and preeclampsia. There are no recent findings on the rs16853055 renin polymorphism. The rs3789678 angiotensinogen polymorphism correlated significantly with gestational hypertension. The rs4305 ACE polymorphism ...
Source: Current Hypertension Reports - February 27, 2024 Category: Primary Care Source Type: research
Resistant Hypertension: Disease Burden and Emerging Treatment Options
AbstractPurpose of ReviewTo define resistant hypertension (RHT), review its pathophysiology and disease burden, identify barriers to effective hypertension management, and to highlight emerging treatment options.Recent FindingsRHT is defined as uncontrolled blood pressure (BP) ≥ 130/80 mm Hg despite concurrent prescription of ≥ 3 or ≥ 4 antihypertensive drugs in different classes or controlled BP despite prescription of ≥ to 4 drugs, at maximally tolerated doses, including a diuretic. BP is regulated by a complex interplay between the renin–angi otensin–aldosterone system, the sympathetic nervo...
Source: Current Hypertension Reports - February 16, 2024 Category: Primary Care Source Type: research
Strategies for Identifying Patients for Deprescribing of Blood Pressure Medications in Routine Practice: An Evidence Review
AbstractPurpose of ReviewTo summarise the evidence regarding which patients might benefit from deprescribing antihypertensive medications.Recent FindingsOlder patients with frailty, multi-morbidity and subsequent polypharmacy are at higher risk of adverse events from antihypertensive treatment, and therefore may benefit from antihypertensive deprescribing. It is possible to examine an individual ’s risk of these adverse events, and use this to identify those people where the benefits of treatment may be outweighed by the harms. While such patients might be considered for deprescribing, the long-term effects of this treat...
Source: Current Hypertension Reports - February 2, 2024 Category: Primary Care Source Type: research
Hyperuricemia: An Intriguing Connection to Metabolic Syndrome, Diabetes, Kidney Disease, and Hypertension
AbstractPurpose of the ReviewOur review explores the epidemiology, physiology, and clinical data surrounding the connection between hyperuricemia and metabolic syndrome, chronic kidney disease, and hypertension.Recent FindingsCompelling physiologic mechanisms have been proposed to explain a causal relationship between hyperuricemia and metabolic syndrome, chronic kidney disease, and hypertension but clinical studies have given mixed results in terms of whether intervening with hyperuricemia using urate-lowering therapy has any beneficial effects for patients with these conditions.SummaryDespite the large amount of research...
Source: Current Hypertension Reports - January 25, 2024 Category: Primary Care Source Type: research
Update on the Use of Pulse Wave Velocity to Measure Age-Related Vascular Changes
AbstractPurpose of ReviewPulse wave velocity (PWV) is an important and well-established measure of arterial stiffness that is strongly associated with aging. Age-related alterations in the elastic properties and integrity of arterial walls can lead to cardiovascular disease. PWV measurements play an important role in the early detection of these changes, as well as other cardiovascular disease risk fa ctors, such as hypertension. This review provides a comprehensive summary of the current knowledge of the effects of aging on arterial stiffness, as measured by PWV.Recent FindingsThis review highlights recent findings ...
Source: Current Hypertension Reports - December 30, 2023 Category: Primary Care Source Type: research
Managing Hypertension in Older Adults
AbstractPurpose of ReviewThe population of older adults 60 –79 years globally is projected to double from 800 million to 1.6 billion between 2015 and 2050, while adults ≥ 80 years were forecast to more than triple from 125 to 430 million. The risk for cardiovascular events doubles with each decade of aging and each 20 mmHg increase of systolic bl ood pressure. Thus, successful management of hypertension in older adults is critical in mitigating the projected global health and economic burden of cardiovascular disease.Recent FindingsWomen live longer than men, yet with aging systolic blood pressure and prevalent ...
Source: Current Hypertension Reports - December 27, 2023 Category: Primary Care Source Type: research
Cell-Free Nucleic Acids for Early Prediction of Preeclampsia
AbstractPurpose of ReviewThis review summarizes the potential of cell-free nucleic acids for predicting preeclampsia, contrasts them with other methods, and discusses these findings ’ relevance to preeclampsia’s pathogenesis and care.Recent FindingsRecent studies have demonstrated the utility of cell-free nucleic acids in early preeclampsia risk prediction. Encouragingly, nucleic acid measurement exhibits similar or better sensitivity as compared to standard screening assays and furthermore sheds light on preeclampsia ’s underlying placental biology.SummaryOver the past decade, liquid biopsies measuring cell-free nuc...
Source: Current Hypertension Reports - December 26, 2023 Category: Primary Care Source Type: research
Preeclampsia and the Retina
AbstractPurpose of ReviewThis review summarizes key findings relating to the association between preeclampsia and retinal disorders.Recent FindingsPreeclampsia is a major cause of maternal morbidity. Pregnant women with preeclampsia frequently describe having visual disturbances. Retinal changes can be identified on fundoscopy in most patients with preeclampsia. While retinal pathology secondary to preeclampsia usually resolves postpartum, there is growing evidence that women with preeclampsia have a higher long-term risk of developing retinal disorders after pregnancy.SummaryPregnant women often experience visual changes....
Source: Current Hypertension Reports - December 22, 2023 Category: Primary Care Source Type: research
