Use of Self-Measured Blood Pressure Monitoring to Improve Hypertension Equity
AbstractPurpose of ReviewTo evaluate how self-measured blood pressure (SMBP) monitoring interventions impact hypertension equity.Recent FindingsWhile a growing number of studies have recruited participants from safety-net settings, racial/ethnic minority groups, rural areas, or lower socio-economic backgrounds, few have reported on clinical outcomes with many choosing to evaluate only patient-reported outcomes (e.g., satisfaction, engagement). The studies with clinical outcomes demonstrate that SMBP monitoring (a) can be successfully adopted by historically excluded patient populations and safety-net settings and (b) impro...
Source: Current Hypertension Reports - August 24, 2022 Category: Primary Care Source Type: research
Lifestyle Interventions for Elevated Blood Pressure in Childhood —Approaches and Outcomes
AbstractPurpose of ReviewThe purpose of this review is to provide an overview of existing and emerging lifestyle treatments in the clinical management of primary elevated blood pressure and hypertension in pediatric patients. The authors hope to expand the knowledge base surrounding pediatric hypertension and update clinicians on best practices to improve outcomes.Recent FindingsElevated blood pressure is traditionally addressed with broad lifestyle recommendations such as limiting salt consumption and losing weight. This approach is not well adapted for pediatric patients. Novel and often underutilized approaches to the t...
Source: Current Hypertension Reports - August 16, 2022 Category: Primary Care Source Type: research
Antihypertensive Deprescribing in Older Adults: a Practical Guide
AbstractPurpose of ReviewTo summarise evidence on both appropriate and inappropriate antihypertensive drug withdrawal.Recent FindingsDeprescribing should be attempted in the following steps: (1) identify patients with several comorbidities and significant functional decline, i.e. people at higher risk for negative outcomes related to polypharmacy and lower blood pressure; (2) check blood pressure; (3) identify candidate drugs for deprescribing; (4) withdraw medications at 4-week intervals; (5) monitor blood pressure and check for adverse events. Although evidence is accumulating regarding short-term outcomes of antihyperte...
Source: Current Hypertension Reports - July 26, 2022 Category: Primary Care Source Type: research
Hypertension in Cancer Survivors
AbstractPurpose of ReviewWith increasing survival after cancer treatment, there is a need for long-term management of risk factors and chronic medical conditions to realize the full benefit of improvement of outcomes. Hypertension is a major risk factor for cardiovascular disease and has a higher prevalence in cancer survivors compared to the general population. In this review article, we discuss the burden of hypertension in cancer survivors and how this impacts their long-term outcomes and risk of cancer recurrence. We then discuss the latest concepts regarding the pathophysiology of hypertension in cancer survivors in d...
Source: Current Hypertension Reports - July 19, 2022 Category: Primary Care Source Type: research
How Dietary Fibre, Acting via the Gut Microbiome, Lowers Blood Pressure
AbstractPurpose of ReviewTo discuss the interplay behind how a high-fibre diet leads to lower blood pressure (BP) via the gut microbiome.Recent FindingsCompelling evidence from meta-analyses support dietary fibre prevents the development of cardiovascular disease and reduces BP. This relation is due to gut microbial metabolites, called short-chain fatty acids (SCFAs), derived from fibre fermentation. The SCFAs acetate, propionate and butyrate lower BP in independent hypertensive models. Mechanisms are diverse but still not fully understood —for example, they include G protein-coupled receptors, epigenetics, immune cells,...
Source: Current Hypertension Reports - July 15, 2022 Category: Primary Care Source Type: research
Epigenetic Mechanisms Involved in Inflammaging-Associated Hypertension
AbstractPurpose of ReviewThis review summarizes the involvement of inflammaging in vascular damage with focus on the epigenetic mechanisms by which inflammaging-induced hypertension is triggered.Recent FindingsInflammaging in hypertension is a complex condition associated with the production of inflammatory mediators by the immune cells, enhancement of oxidative stress, and tissue remodeling in vascular smooth muscle cells and endothelial cells. Cellular processes are numerous, including inflammasome assembly and cell senescence which may involve mitochondrial dysfunction, autophagy, DNA damage response, dysbiosis, and man...
Source: Current Hypertension Reports - July 7, 2022 Category: Primary Care Source Type: research
WNT/ β-catenin Pathway: a Possible Link Between Hypertension and Alzheimer’s Disease
AbstractPurpose of ReviewRecent research has shown that older people with high blood pressure (BP), or hypertension, are more likely to have biomarkers of Alzheimer ’s disease (AD). Essential hypertension represents the most common cardiovascular disease worldwide and is thought to be responsible for about 13% of all deaths. People with essential hypertension who regularly take prescribed BP medications are half as likely to develop AD as those who do not tak e them. What then is the connection?Recent FindingsWe know that high BP can damage small blood vessels in the brain, affecting those parts that are responsible for ...
Source: Current Hypertension Reports - July 5, 2022 Category: Primary Care Source Type: research
Cardiovascular Disease Risk Reduction and Body Mass Index
AbstractPurpose of ReviewAnti-hypertensive and lipid lowering therapy addresses only half of the cardiovascular disease risk in patients with body mass index > 30 kg/m2, i.e., obesity. We examine newer aspects of obesity pathobiology that underlie the partial effectiveness of anti-hypertensive lipid lowering therapy for the reduction of cardiovascular disease risk in obesity.Recent FindingsObesity-related insulin resistance, vascular endothelium dysfunction, increased sympathetic nervous system/renin –angiotensin–aldosterone system activity, and glomerulopathy lead to type 2 diabetes, coronary atherosclerosis...
Source: Current Hypertension Reports - July 5, 2022 Category: Primary Care Source Type: research
Updated Blood Pressure Guidelines: Implications for Athletes
AbstractPurpose of ReviewTo review the prevalence, short- and long-term impact of exercise on blood pressure, and the evaluation and treatment of hypertension in competitive athletes.Recent FindingsDue, in part, to inconsistencies in measurement and the definitions used, the true prevalence of hypertension is unknown as reports range from 0 to 83%. With recent changes in the blood pressure guidelines, the proportion of athletes that meet criteria for elevated blood pressure or stage 1 hypertension has increased dramatically with over one-third of collegiate and professional athletes meeting criteria for hypertension. Data ...
Source: Current Hypertension Reports - July 5, 2022 Category: Primary Care Source Type: research
WNT/ β-catenin Pathway: a Possible Link Between Hypertension and Alzheimer’s Disease
AbstractPurpose of ReviewRecent research has shown that older people with high blood pressure (BP), or hypertension, are more likely to have biomarkers of Alzheimer ’s disease (AD). Essential hypertension represents the most common cardiovascular disease worldwide and is thought to be responsible for about 13% of all deaths. People with essential hypertension who regularly take prescribed BP medications are half as likely to develop AD as those who do not tak e them. What then is the connection?Recent FindingsWe know that high BP can damage small blood vessels in the brain, affecting those parts that are responsible for ...
Source: Current Hypertension Reports - July 5, 2022 Category: Primary Care Source Type: research
