Beta-Blockers in Pregnancy: Clinical Update
AbstractPurpose of ReviewThe aim of this review was to determine the anticipated benefits and adverse effects of beta-blockers in pregnant women with hypertension. The other issue was to assess the possible adverse effects of beta-blockers for their babies and provide current consensus recommendations for appropriate selection and individualized antihypertensive treatment with beta-blockers in pregnancy-associated hypertension.Recent FindingsHypertensive disorders of pregnancy are a major cause of maternal and fetal morbidity, with consequences later in life. Certain beta-blockers are useful for ameliorating hypertension i...
Source: Current Hypertension Reports - February 3, 2023 Category: Primary Care Source Type: research
Six Decades of History of Hypertension Research at the University of Toledo: Highlighting Pioneering Contributions in Biochemistry, Genetics, and Host-Microbiota Interactions
AbstractPurpose of ReviewThe study aims to capture the history and lineage of hypertension researchers from the University of Toledo in Ohio and showcase their collective scientific contributions dating from their initial discoveries of the physiology of adrenal and renal systems and genetics regulating blood pressure (BP) to its more contemporary contributions including microbiota and metabolomic links to BP regulation.Recent FindingsThe University of Toledo College of Medicine and Life Sciences (UTCOMLS), previously known as the Medical College of Ohio, has contributed significantly to our understanding of the etiology o...
Source: Current Hypertension Reports - December 1, 2022 Category: Primary Care Source Type: research
Hypertension Across a Woman ’s Life Cycle
AbstractPurpose of ReviewWe reviewed the effects of hypertension and the means to prevent and treat it across the spectrum of a woman ’s lifespan and identified gaps in sex-specific mechanisms contributing to hypertension in women that need to be addressed.Recent FindingsHypertension continues to be an important public health problem for women across all life stages from adolescence through pregnancy, menopause, and older age. There remain racial, ethnic, and socioeconomic differences in hypertension rates not only overall but also between the sexes. Blood pressure cutoffs during pregnancy have not been updated to reflec...
Source: Current Hypertension Reports - December 1, 2022 Category: Primary Care Source Type: research
Cardiovascular Dysfunction in Intrauterine Growth Restriction
AbstractPurpose of ReviewWe highlight important new findings on cardiovascular dysfunction in intrauterine growth restriction.Recent FindingsIntrauterine growth restriction (IUGR) is a multifactorial condition which negatively impacts neonatal growth during pregnancy and is associated with health problems during the lifespan. It affects 5 –15% of all pregnancies in the USA and Europe with varying percentages in developing countries. Epidemiological studies have reported that IUGR is associated with the pathogenesis of hypertension, activation of the renin-angiotensin system (RAS), disruption in placental-mTORC and TGFβ ...
Source: Current Hypertension Reports - December 1, 2022 Category: Primary Care Source Type: research
Hypoxia-Inducible Factor 1 and Preeclampsia: A New Perspective
The objective of the present narrative review was to find the association between PE and hypoxia-inducible factor 1 (HIF-1) in pregnant women from a new perspective.Recent FindingsHIF-1 is the key transcription factor that regulates cellular responses to hypoxia and low oxygen tension. HIF-1 α is involved in the differentiation and growth of the placenta mainly in the first and second trimesters. During normal gestation, HIF-1α responds to the alterations in oxygen tension, cytokine, and angiogenic factors release. HIF-1α is considered a key biomarker of placental function and vascul arization during pregnancy.SummaryHI...
Source: Current Hypertension Reports - December 1, 2022 Category: Primary Care Source Type: research
Does the Naked Emperor Parable Apply to Current Perceptions of the Contribution of Renin Angiotensin System Inhibition in Hypertension?
AbstractPurpose of ReviewTo address contemporary hypertension challenges, a critical reexamination of therapeutic accomplishments using angiotensin converting enzyme inhibitors and angiotensin II receptor blockers, and a greater appreciation of evidence-based shortcomings from randomized clinical trials are fundamental in accelerating future progress.Recent FindingsMedications targeting angiotensin II mechanism of action are essential for managing primary hypertension, type 2 diabetes, heart failure, and chronic kidney disease. While the ability of angiotensin converting enzyme inhibitors and angiotensin II receptor bloc...
Source: Current Hypertension Reports - December 1, 2022 Category: Primary Care Source Type: research
Ambulatory Blood Pressure Monitoring in Pediatrics, an Update on Interpretation and Classification of Hypertension Phenotypes
AbstractPurpose of Review
This review highlights the major changes reflected in the 2022 American Heart Association (AHA) Scientific Statement on Ambulatory Blood Pressure Monitoring (ABPM) in Children and Adolescents with a specific focus on the newly defined phenotypes of hypertension and their epidemiology and associated outcomes.Recent FindingsThe 2022 AHA guidelines ’ most notable changes include the following: (1) alignment of blood pressure (BP) thresholds with the 2017 American Academy of Pediatrics (AAP) clinical practice guidelines, 2017 American College of Cardiology (ACC)/AHA hypertension guidelines, and 2...
Source: Current Hypertension Reports - November 25, 2022 Category: Primary Care Source Type: research
Hypertension Across a Woman ’s Life Cycle
AbstractPurpose of ReviewWe reviewed the effects of hypertension and the means to prevent and treat it across the spectrum of a woman ’s lifespan and identified gaps in sex-specific mechanisms contributing to hypertension in women that need to be addressed.Recent FindingsHypertension continues to be an important public health problem for women across all life stages from adolescence through pregnancy, menopause, and older age. There remain racial, ethnic, and socioeconomic differences in hypertension rates not only overall but also between the sexes. Blood pressure cutoffs during pregnancy have not been updated to reflec...
Source: Current Hypertension Reports - November 9, 2022 Category: Primary Care Source Type: research
Hypoxia-Inducible Factor 1 and Preeclampsia: A New Perspective
The objective of the present narrative review was to find the association between PE and hypoxia-inducible factor 1 (HIF-1) in pregnant women from a new perspective.Recent FindingsHIF-1 is the key transcription factor that regulates cellular responses to hypoxia and low oxygen tension. HIF-1 α is involved in the differentiation and growth of the placenta mainly in the first and second trimesters. During normal gestation, HIF-1α responds to the alterations in oxygen tension, cytokine, and angiogenic factors release. HIF-1α is considered a key biomarker of placental function and vascul arization during pregnancy.SummaryHI...
Source: Current Hypertension Reports - November 7, 2022 Category: Primary Care Source Type: research
Cardiovascular Dysfunction in Intrauterine Growth Restriction
AbstractPurpose of ReviewWe highlight important new findings on cardiovascular dysfunction in intrauterine growth restriction.Recent FindingsIntrauterine growth restriction (IUGR) is a multifactorial condition which negatively impacts neonatal growth during pregnancy and is associated with health problems during the lifespan. It affects 5 –15% of all pregnancies in the USA and Europe with varying percentages in developing countries. Epidemiological studies have reported that IUGR is associated with the pathogenesis of hypertension, activation of the renin-angiotensin system (RAS), disruption in placental-mTORC and TGFβ ...
Source: Current Hypertension Reports - November 2, 2022 Category: Primary Care Source Type: research
Six Decades of History of Hypertension Research at the University of Toledo: Highlighting Pioneering Contributions in Biochemistry, Genetics, and Host-Microbiota Interactions
AbstractPurpose of ReviewThe study aims to capture the history and lineage of hypertension researchers from the University of Toledo in Ohio and showcase their collective scientific contributions dating from their initial discoveries of the physiology of adrenal and renal systems and genetics regulating blood pressure (BP) to its more contemporary contributions including microbiota and metabolomic links to BP regulation.Recent FindingsThe University of Toledo College of Medicine and Life Sciences (UTCOMLS), previously known as the Medical College of Ohio, has contributed significantly to our understanding of the etiology o...
Source: Current Hypertension Reports - October 27, 2022 Category: Primary Care Source Type: research
Does the Naked Emperor Parable Apply to Current Perceptions of the Contribution of Renin Angiotensin System Inhibition in Hypertension?
AbstractPurpose of ReviewTo address contemporary hypertension challenges, a critical reexamination of therapeutic accomplishments using angiotensin converting enzyme inhibitors and angiotensin II receptor blockers, and a greater appreciation of evidence-based shortcomings from randomized clinical trials are fundamental in accelerating future progress.Recent FindingsMedications targeting angiotensin II mechanism of action are essential for managing primary hypertension, type 2 diabetes, heart failure, and chronic kidney disease. While the ability of angiotensin converting enzyme inhibitors and angiotensin II receptor bloc...
Source: Current Hypertension Reports - October 22, 2022 Category: Primary Care Source Type: research
