Key to the Treatment of Primary Aldosteronism in Secondary Hypertension: Subtype Diagnosis
AbstractPurpose of ReviewPrimary aldosteronism (PA) is a leading global cause of secondary hypertension. Subtyping diagnosis of PA is the key to surgery, but accurate classification of PA is crucial but challenging in clinical diagnosis and treatment. The purpose of this review is to provide a summary of current literature and propose subtyping diagnosis flow chart to help us classify PA quickly and accurately.Recent FindingsEarly diagnosis and accurate typing are essential for the timely treatment and appropriate management of PA. For most patients, adrenal venous sampling (AVS) is the central choice for typing diagnosis,...
Source: Current Hypertension Reports - October 3, 2023 Category: Primary Care Source Type: research
Role of Inflammatory Processes in the Brain-Body Relationship Underlying Hypertension
AbstractPurpose of ReviewEssential hypertension is a huge health problem that significantly impacts worldwide population in terms of morbidity and mortality. Idiopathic in its nature, elevated blood pressure results from a complex interaction between polygenic components and environmental and lifestyle factors. The constant growth in the burden of hypertension is at odds with expectations, considering the availability of therapeutic strategies. Hence, there is an endless need to further investigate the complexity of factors contributing to blood pressure elevation.Recent FindingsRecent data indicate that bidirectional inte...
Source: Current Hypertension Reports - October 3, 2023 Category: Primary Care Source Type: research
Key to the Treatment of Primary Aldosteronism in Secondary Hypertension: Subtype Diagnosis
AbstractPurpose of ReviewPrimary aldosteronism (PA) is a leading global cause of secondary hypertension. Subtyping diagnosis of PA is the key to surgery, but accurate classification of PA is crucial but challenging in clinical diagnosis and treatment. The purpose of this review is to provide a summary of current literature and propose subtyping diagnosis flow chart to help us classify PA quickly and accurately.Recent FindingsEarly diagnosis and accurate typing are essential for the timely treatment and appropriate management of PA. For most patients, adrenal venous sampling (AVS) is the central choice for typing diagnosis,...
Source: Current Hypertension Reports - October 3, 2023 Category: Primary Care Source Type: research
Role of Inflammatory Processes in the Brain-Body Relationship Underlying Hypertension
AbstractPurpose of ReviewEssential hypertension is a huge health problem that significantly impacts worldwide population in terms of morbidity and mortality. Idiopathic in its nature, elevated blood pressure results from a complex interaction between polygenic components and environmental and lifestyle factors. The constant growth in the burden of hypertension is at odds with expectations, considering the availability of therapeutic strategies. Hence, there is an endless need to further investigate the complexity of factors contributing to blood pressure elevation.Recent FindingsRecent data indicate that bidirectional inte...
Source: Current Hypertension Reports - October 3, 2023 Category: Primary Care Source Type: research
Challenging Health Inequities in Incarceration: a Call for Equitable Care for Kidney Disease and Hypertension
AbstractPurpose of ReviewTo review the current literature on care of hypertension and chronic kidney disease for people who are currently and formerly incarcerated, and to make recommendations for improving outcomes.Recent FindingsThere is a growing body of literature describing care for kidney disease and hypertension for incarcerated and formerly incarcerated individuals that documents the provision of care itself, notably that many jails contract with private companies; the system is not designed to provide sustained, chronic disease care; and the transition from incarceration to community is fraught with gaps in care. ...
Source: Current Hypertension Reports - September 29, 2023 Category: Primary Care Source Type: research
Management of Hyperkalemia in Patients with Chronic Kidney Disease Using Renin Angiotensin Aldosterone System Inhibitors
AbstractPurpose of ReviewUse of renin –angiotensin–aldosterone system (RAAS) inhibiting medications is critical in the prevention of cardiovascular disease and kidney function decline in patients with chronic kidney disease (CKD); however, these agents can lead to hyperkalemia, an electrolyte disorder associated with risk of arrythm ia, conduction disorders, and increased overall mortality. Discontinuation, or reduction of dose, of RAAS inhibitor therapy in hyperkalemic patients with CKD can lead to loss of kidney and cardiovascular protection afforded by these medications. Given the high prevalence of hyperkalemia amo...
Source: Current Hypertension Reports - September 25, 2023 Category: Primary Care Source Type: research
Angiotensin Receptor Blockers and Cognition: a Scoping Review
AbstractPurpose of ReviewTo provide an overview of the association between angiotensin II receptor blocker (ARB) use and cognitive outcomes.Recent FindingsARBs have previously shown greater neuroprotection compared to other anti-hypertensive classes. The benefits are primarily attributed to the ARB ’s effect on modulating the renin-angiotensin system via inhibiting the Ang II/AT1R pathway and activating the Ang II/AT2R, Ang IV/AT4R, and Ang-(1–7)/MasR pathways. These interactions are associated with pleiotropic neurocognitive benefits, including reduced β-amyloid accumulation and abnormal hyperphosphorylation of tau, ...
Source: Current Hypertension Reports - September 21, 2023 Category: Primary Care Source Type: research
Role of Female Sex Hormones and Immune Response in Salt-Sensitive Hypertension Development: Evidence from Experimental Models
We describe experiences of different research groups and our own, on aspects related to the importance of female sex hormones on blood pressure (BP) regulation and salt-sensitivity-mediated BP response and salt sensitivity without alterations in BP, as well as renal sodium handling and interactions with the immune system.Recent FindingsChanges in sodium intake in normotensive premenopausal women cause more BP variations than in men. After menopause, women often develop arterial hypertension (HT) with a profile of sodium sensitivity. Besides, experimental results have shown that in adult rat models resembling the postmenopa...
Source: Current Hypertension Reports - September 7, 2023 Category: Primary Care Source Type: research
Does Renal Denervation a Reasonable Treatment Option in Hemodialysis-Dependent Patient with Resistant Hypertension? A Narrative Review
AbstractPurpose of ReviewThis narrative review aims to assess the pathophysiology, diagnosis, and treatment of resistant hypertension (RH) in end-stage kidney disease (ESKD) patients on dialysis, with a specific focus on the effect of renal denervation (RDN) on short-term and long-term blood pressure (BP) control. Additionally, we share our experience with the use of RDN in an amyloidotic patient undergoing hemodialysis with RH.Recent FindingsHigh BP, an important modifiable cardiovascular risk factor, is often observed in patients in ESKD, despite the administration of multiple antihypertensive medications. However, in cl...
Source: Current Hypertension Reports - September 6, 2023 Category: Primary Care Source Type: research
Predicting Changes in Systolic and Diastolic Blood Pressure of Hypertensive Patients in Indonesia Using Machine Learning
AbstractPurpose of ReviewThis retrospective study investigated factors that influence the occurrence of decreased systolic and diastolic blood pressure including sociodemographic and economic factors, hypertension duration, cigarette consumption, alcohol consumption, duration of smoking, type of cigarettes, exercise, salt consumption, sleeping pills consumption, insomnia, and diabetes. These factors were applied to predict the reality of systolic and diastolic decrease using the machine learning algorithm Na ïve Bayes, artificial neural network, logistic regression, and decision tree.Recent FindingsThe increase in blood p...
Source: Current Hypertension Reports - August 29, 2023 Category: Primary Care Source Type: research
