Should a Statin be Given to All Hypertensive Patients?
AbstractPurpose of ReviewTo review the milestone trials and recent literature supporting statin therapy for prevention of atherosclerotic cardiovascular disease (ASCVD) and to provide rationale for more generalized use of statin therapy among patients treated for hypertension.Recent FindingsHypertension is a leading modifiable risk factor for ASCVD worldwide. Randomized controlled trial evidence supports initiation of antihypertensive medication for stage 2 hypertension regardless of ASCVD risk. The HOPE-3 trial tested statin therapy in intermediate-risk individuals (defined as an annual risk of major cardiovascular events...
Source: Current Hypertension Reports - January 24, 2022 Category: Primary Care Source Type: research
Firibastat: a Novel Treatment for Hypertension
AbstractPurpose of ReviewThe purpose of this review is to discuss the unique mechanism of firibastat, a new antihypertension medication. Hypertension continues to be a highly prevalent public health issue.Recent FindingsFiribastat is a novel agent developed to treat hypertension. As the first member in the class of centrally acting agents to target the brain renin angiotensin system, firibastat offers new pathways to consider and enhances the regimen of agents currently available to treat hypertension. Recent clinical trials have demonstrated effectiveness and safety in mild hypertension as well as resistant hypertension.S...
Source: Current Hypertension Reports - December 24, 2021 Category: Primary Care Source Type: research
Lipoprotein (a) and Hypertension
AbstractPurpose of ReviewTo provide an overview of the associations between elevated blood pressure and lipoprotein (a) and possible causal links, as well as data on the prevalence of elevated lipoprotein (a) in a cohort of hypertensive patients.Recent FindingsElevated lipoprotein (a) is now considered to be an independent and causal risk factor for atherosclerotic cardiovascular disease and calcific aortic valve disease. Despite this, there are limited data demonstrating an association between elevated lipoprotein (a) and hypertension. Further, there is limited mechanistic data linking lipoprotein (a) and hypertension thr...
Source: Current Hypertension Reports - December 9, 2021 Category: Primary Care Source Type: research
T Cell Immunometabolism and Redox Signaling in Hypertension
AbstractPurpose of ReviewIn this article, we summarize the current literature supporting metabolic and redox signaling pathways as important mechanisms underlying T cell activation in the context of hypertension.Recent FindingsT cell immunometabolism undergoes dramatic remodeling in order to meet the demands of T cell activation, differentiation, and proliferation. Recent evidence demonstrates that the T cell oxidation –reduction (redox) system also undergoes significant changes upon activation, which can itself modulate metabolic processes and T cell function. Dysregulation of these signaling pathways can lead to aberra...
Source: Current Hypertension Reports - December 9, 2021 Category: Primary Care Source Type: research
Lipoprotein (a) and Hypertension
AbstractPurpose of ReviewTo provide an overview of the associations between elevated blood pressure and lipoprotein (a) and possible causal links, as well as data on the prevalence of elevated lipoprotein (a) in a cohort of hypertensive patients.Recent FindingsElevated lipoprotein (a) is now considered to be an independent and causal risk factor for atherosclerotic cardiovascular disease and calcific aortic valve disease. Despite this, there are limited data demonstrating an association between elevated lipoprotein (a) and hypertension. Further, there is limited mechanistic data linking lipoprotein (a) and hypertension thr...
Source: Current Hypertension Reports - December 9, 2021 Category: Primary Care Source Type: research
T Cell Immunometabolism and Redox Signaling in Hypertension
AbstractPurpose of ReviewIn this article, we summarize the current literature supporting metabolic and redox signaling pathways as important mechanisms underlying T cell activation in the context of hypertension.Recent FindingsT cell immunometabolism undergoes dramatic remodeling in order to meet the demands of T cell activation, differentiation, and proliferation. Recent evidence demonstrates that the T cell oxidation –reduction (redox) system also undergoes significant changes upon activation, which can itself modulate metabolic processes and T cell function. Dysregulation of these signaling pathways can lead to aberra...
Source: Current Hypertension Reports - December 9, 2021 Category: Primary Care Source Type: research
The Effect of Behavioral Changes on the Treatment of Hypertension
AbstractPurpose of ReviewHypertension is one of the leading causes of preventable premature death.Recent FindingsStrongly advocating for lifestyle changes to improve blood pressure control is of paramount importance in the successful management of hypertension.SummaryIn this review, we will discuss the effect of various behavioral and lifestyle changes and review the evidence to support these changes to improve blood pressure control. These include dietary modifications, alcohol consumption, weight loss, various types of exercise, device-guided breathing, relaxation, and biofeedback techniques. (Source: Current Hypertension Reports)
Source: Current Hypertension Reports - November 24, 2021 Category: Primary Care Source Type: research
The Effect of Alcohol on Blood Pressure and Hypertension
AbstractPurposeTo examine the acute and chronic effects of alcohol on blood pressure (BP) and the incidence of hypertension. We discuss the most current understanding of the mechanisms underlining these effects and their associations with the putative cardioprotective effects of consumption of low-to-moderate amounts of alcoholic beverages.Recent FindingsA recent meta-analysis confirmed findings of experimental studies, demonstrating an acute biphasic effect of ethanol on BP, decreasing up to 12 h of ingestion and increasing after that. This effect is mediated by vagal inhibition and sympathetic activation. A meta-analys...
Source: Current Hypertension Reports - November 11, 2021 Category: Primary Care Source Type: research
Long-term Trends in Hypertension Prevalence, Awareness, Treatment, and Control Rate in the Middle East and North Africa: a Systematic Review and Meta-analysis of 178 Population-Based Studies
This study investigated and pooled the long-term trends in prevalence, awareness, treatment, and control of hypertension (HTN) in the Middle East and North Africa (MENA) region. In this systematic review and meta-analysis, we searched MEDLINE/PubMed, Web of Science, Google Scholar, EMBASE, and Scopus between database inception and November 2020. All cross-sectional studies that investigated the prevalence of pre-HTN, HTN, awareness, treatment, and control in the MENA coun ties were included. The selection study, data extraction, and quality assessment were conducted by two investigators independently. Heterogeneity betwe...
Source: Current Hypertension Reports - October 8, 2021 Category: Primary Care Source Type: research
The Role of Gut Microbiota in Hypertension Pathogenesis and the Efficacy of Antihypertensive Drugs
AbstractPurpose of HeadingTo review the relationship between intestinal microbes and hypertension and its impact on the efficacy of antihypertensive drugs, and help to address some of these knowledge gaps.Recent FindingsHypertension is associated with cardiovascular diseases and is the most important modifiable risk factor for all-cause morbidity and mortality worldwide. The pathogenesis of hypertension is complex, including factors such as dietary, environmental and genetics. Recently, the studies have shown that the gut microbiota influences the occurrence and development of hypertension through a variety of ways, includ...
Source: Current Hypertension Reports - September 6, 2021 Category: Primary Care Source Type: research
