Newer Drugs to Reduce High Blood Pressure and Mitigate Hypertensive Target Organ Damage
AbstractPurpose of ReviewThis review aims to investigate the blood pressure (BP)-lowering effects of emerging drugs developed to treat diabetic kidney disease and heart failure (HF). We summarize the potential pathophysiological mechanisms responsible for mitigating hypertensive target organ damage and evaluating the available clinical data on these newer drugs.Recent FindingsNonsteroidal dihydropyridine-based mineralocorticoid receptor antagonists (MRAs), dual angiotensin II receptor-neprilysin inhibitors (valsartan with sacubitril), sodium-glucose cotransporter 2 inhibitors (SGLT2i), and soluble guanylate cyclase stimula...
Source: Current Hypertension Reports - February 14, 2022 Category: Primary Care Source Type: research
High Prevalence of Autonomous Aldosterone Production in Hypertension: How to Identify and Treat It
AbstractPurpose of ReviewPrimary aldosteronism (PA) affects millions of individuals worldwide. When unrecognized, PA leads to cardiovascular and renal complications via mechanisms independent from those mediated by hypertension. In this review, we emphasize the importance of PA screening in at-risk populations, and we provide options for customized PA therapy, with consideration for a variety of clinical care settings.Recent FindingsCompelling evidence puts PA at the forefront of secondary hypertension etiologies. Cardiovascular and renal damage likely begins in early stages of renin-independent aldosterone excess. PA must...
Source: Current Hypertension Reports - February 14, 2022 Category: Primary Care Source Type: research
Newer Drugs to Reduce High Blood Pressure and Mitigate Hypertensive Target Organ Damage
AbstractPurpose of ReviewThis review aims to investigate the blood pressure (BP)-lowering effects of emerging drugs developed to treat diabetic kidney disease and heart failure (HF). We summarize the potential pathophysiological mechanisms responsible for mitigating hypertensive target organ damage and evaluating the available clinical data on these newer drugs.Recent FindingsNonsteroidal dihydropyridine-based mineralocorticoid receptor antagonists (MRAs), dual angiotensin II receptor-neprilysin inhibitors (valsartan with sacubitril), sodium-glucose cotransporter 2 inhibitors (SGLT2i), and soluble guanylate cyclase stimula...
Source: Current Hypertension Reports - February 14, 2022 Category: Primary Care Source Type: research
Sox6, A Potential Target for MicroRNAs in Cardiometabolic Disease
AbstractPurpose of ReviewThe study aims to review recent advances in knowledge on the interplay between miRNAs and thesex-determining Region Y (SRY)-related high-mobility-group box 6 (Sox6) in physiology and pathophysiology, highlighting an important role in autoimmune and cardiometabolic conditions.Recent FindingsThe transcription factor Sox6 is an important member of the SoxD family and plays an indispensable role in adult tissue homeostasis, regeneration, and physiology. Abnormal expression of the Sox6 gene has been implicated in several disease conditions including diabetes, cardiomyopathy, autoimmune diseases, and hyp...
Source: Current Hypertension Reports - February 5, 2022 Category: Primary Care Source Type: research
The Burden of Resistant Hypertension Across the World
AbstractPurpose of ReviewResistant hypertension (R-HTN) is related to worse cardiovascular, renal outcomes, and death compared to non R-HTN. We aimed to review the burden of R-HTN across the world, focusing on its prevalence, associated factors and outcomes, and the impact of treatment.Recent FindingsR-HTN prevalence among hypertensive individuals varies around 10 –20%, depending on the population and definition applied. R-HTN consistently relates to older age, chronic kidney disease, obesity, and obstructive sleep apnea – which are increasing in prevalence with global population aging. As such, R-HTN prevalence is als...
Source: Current Hypertension Reports - February 3, 2022 Category: Primary Care Source Type: research
Effects of Alcohol Reduction Interventions on Blood Pressure
AbstractPurpose of ReviewMuch of alcohol ’s purported negative impact on a population’s health can be attributed to its association with increased blood pressure, rates of hypertension, and incidence of cardiovascular disease (CVD). Less attention, however, has been placed on the association of the positive impact of alcohol reduction interventions on physical health.Recent FindingsThis review delineates the evidence of blood pressure reductions as a function of alcohol reduction interventions based on current care models. The findings of this review suggest two things: (1) sufficient evidence exists for a relationship...
Source: Current Hypertension Reports - February 2, 2022 Category: Primary Care Source Type: research
Refractory Hypertension: a Narrative Systematic Review with Emphasis on Prognosis
AbstractPurpose of ReviewTo perform a narrative systematic review on refractory hypertension (RfHT) with particular emphasis on prognosis.Recent FindingsThere were 37 articles on RfHT, 13 non-systematic reviews, and 24 original studies. RfHT, a recently described extreme phenotype of anti-hypertensive treatment failure, shall be defined as uncontrolled out-of-office blood pressure (BP) levels despite the use of at least 5 anti-hypertensive drugs, including a long-acting diuretic and a mineraloreceptor antagonist. Its prevalence ranges from 0.5 to 4.3% of general treated hypertensives and between 3.6 and 51.4% of patients w...
Source: Current Hypertension Reports - February 2, 2022 Category: Primary Care Source Type: research
Effects of Alcohol Reduction Interventions on Blood Pressure
AbstractPurpose of ReviewMuch of alcohol ’s purported negative impact on a population’s health can be attributed to its association with increased blood pressure, rates of hypertension, and incidence of cardiovascular disease (CVD). Less attention, however, has been placed on the association of the positive impact of alcohol reduction interventions on physical health.Recent FindingsThis review delineates the evidence of blood pressure reductions as a function of alcohol reduction interventions based on current care models. The findings of this review suggest two things: (1) sufficient evidence exists for a relationship...
Source: Current Hypertension Reports - February 2, 2022 Category: Primary Care Source Type: research
Refractory Hypertension: a Narrative Systematic Review with Emphasis on Prognosis
AbstractPurpose of ReviewTo perform a narrative systematic review on refractory hypertension (RfHT) with particular emphasis on prognosis.Recent FindingsThere were 37 articles on RfHT, 13 non-systematic reviews, and 24 original studies. RfHT, a recently described extreme phenotype of anti-hypertensive treatment failure, shall be defined as uncontrolled out-of-office blood pressure (BP) levels despite the use of at least 5 anti-hypertensive drugs, including a long-acting diuretic and a mineraloreceptor antagonist. Its prevalence ranges from 0.5 to 4.3% of general treated hypertensives and between 3.6 and 51.4% of patients w...
Source: Current Hypertension Reports - February 2, 2022 Category: Primary Care Source Type: research
Uric Acid, Hypertensive Phenotypes, and Organ Damage: Data from the Pamela Study
AbstractPurpose of ReviewTo examine published and unpublished data collected in the context of the Pressioni Arteriose Monitorate E Loro Associazioni (PAMELA) study on the relationships between serum uric acid (SUA), office and out-of-office blood pressure (BP), and organ damage.Recent FindingsSUA values were directly and significantly related to a large number of covariates that participate at cardiovascular risk determination, such as blood glucose, total serum cholesterol, serum triglycerides, body mass index, and serum creatinine. Additional variables included echocardiographically-determined left ventricular mass inde...
Source: Current Hypertension Reports - January 25, 2022 Category: Primary Care Source Type: research
Emergency Department Management of Hypertension in the Context of COVID-19
AbstractPurpose of ReviewThis review describes the relationship between COVID-19 and hypertension (HTN), and considerations for emergency medicine providers in the management of hypertensive patients during the COVID-19 pandemic.Recent FindingsHypertensive patients with COVID-19 have a higher risk of severe disease/complications, hospitalizations, intensive care unit (ICU) admissions, and mortality than non-hypertensive patients. Studies have also shown the importance of consideration of various demographic factors (such as older age) and socioeconomic factors that may confound these relationships. Despite concerns at the ...
Source: Current Hypertension Reports - January 25, 2022 Category: Primary Care Source Type: research
Uric Acid, Hypertensive Phenotypes, and Organ Damage: Data from the Pamela Study
AbstractPurpose of ReviewTo examine published and unpublished data collected in the context of the Pressioni Arteriose Monitorate E Loro Associazioni (PAMELA) study on the relationships between serum uric acid (SUA), office and out-of-office blood pressure (BP), and organ damage.Recent FindingsSUA values were directly and significantly related to a large number of covariates that participate at cardiovascular risk determination, such as blood glucose, total serum cholesterol, serum triglycerides, body mass index, and serum creatinine. Additional variables included echocardiographically-determined left ventricular mass inde...
Source: Current Hypertension Reports - January 25, 2022 Category: Primary Care Source Type: research
Emergency Department Management of Hypertension in the Context of COVID-19
AbstractPurpose of ReviewThis review describes the relationship between COVID-19 and hypertension (HTN), and considerations for emergency medicine providers in the management of hypertensive patients during the COVID-19 pandemic.Recent FindingsHypertensive patients with COVID-19 have a higher risk of severe disease/complications, hospitalizations, intensive care unit (ICU) admissions, and mortality than non-hypertensive patients. Studies have also shown the importance of consideration of various demographic factors (such as older age) and socioeconomic factors that may confound these relationships. Despite concerns at the ...
Source: Current Hypertension Reports - January 25, 2022 Category: Primary Care Source Type: research
