Masked Hypertension in Healthy Children and Adolescents: Who Should Be Screened?
AbstractPurpose of ReviewThe goal is to review masked hypertension (MH) as a relatively new phenomenon when patients have normal office BP but elevated out-of-office BP. Firstly, it was described in children in 2004. It has received increased attention in the past decade.Recent FindingsThe prevalence of MH in different pediatric populations differs widely between 0 and 60% based on the population studied, definition of MH, or method of out-of-office BP measurement. The highest prevalence of MH has been demonstrated in children with chronic kidney disease (CKD), obesity, diabetes, and after heart transplantation. In healthy...
Source: Current Hypertension Reports - August 28, 2023 Category: Primary Care Source Type: research
Gut Microbiota and Its Role in the Brain-Gut-Kidney Axis in Hypertension
AbstractPurpose of ReviewThe role of the gut microbiota in modulating blood pressure is increasingly being recognized, currently. The purpose of this review is to summarize recent findings about the mechanisms involved in hypertension with regard to the phenomenon of “gut dysbiosis.”Recent FindingsGut dysbiosis, i.e., the imbalance between the gut microbiota and the host, is characterized by a disruption of the tight junction proteins, such as occludins, claudins, and JAMs (junctional adhesion molecules), resulting in increased gut permeability or the so called “leaky gut.” Due to the influence of genetic as well a...
Source: Current Hypertension Reports - August 26, 2023 Category: Primary Care Source Type: research
The Impact of COVID-19 on Hypertension and Hypertension Medication Adherence Among Underrepresented Racial and Ethnic Groups: A Scoping Review
AbstractPurpose of ReviewTo conduct a scoping review of articles which examined the impact of COVID-19 on HTN and HTN medication adherence among underrepresented racial/ethnic minorities.Recent FindingsSeven studies were included in this review and impact of COVID-19 was examined at 4 levels: patient, provider, health system and society. The results indicated that patient level factors, such as high unemployment and inequitable access to telemedicine due to society factors- lack of access to high-speed Internet and variation in the offering of telehealth by health systems, were most impactful on adherence. Additionally, pr...
Source: Current Hypertension Reports - August 25, 2023 Category: Primary Care Source Type: research
Benzodiazepines Reduce Blood Pressure in Short Term: A Systematic Review and Meta-analysis
AbstractPurpose of ReviewBenzodiazepines, due to their anxiolytic properties, are prescribed to reduce anxiety and insomnia. They might have hypotensive effect via potentiation of the inhibitory effect of gamma-amino butyric acid (GABA) in the central nervous system and vasodilatory properties. However, studies comparing the effect of benzodiazepines in lowering blood pressure (BP) are equivocal. This systematic review and meta-analysis was planned to assess the efficacy of benzodiazepines in reducing blood pressure in short term among hypertensive patients.Recent FindingsVarious trials and retrospective analysis conducted...
Source: Current Hypertension Reports - August 15, 2023 Category: Primary Care Source Type: research
Dual Endothelin Antagonism with Aprocitentan as a Novel Therapeutic Approach for Resistant Hypertension
AbstractPurpose of ReviewResistant hypertension (RH) defined as uncontrolled blood pressure despite the use of a combination of a renin-angiotensin system blocker, a calcium channel blocker, and a diuretic at maximally tolerated doses is associated with a substantially increased risk of cardiovascular and renal events. Despite targeting relevant pathophysiological pathways contributing to elevated blood pressure, approximately 10 –15% of hypertensive patients remain above recommended blood pressure targets. Further optimization of blood pressure control is particularly challenging in patient populations who frequently ...
Source: Current Hypertension Reports - August 11, 2023 Category: Primary Care Source Type: research
Irregularities of Coagulation in Hypertension
This article concludes that D-dimer, fibrinogen and fibrin, prothrombin, P-selectin, soluble urokinase plasminogen activator receptor, thrombomodulin, tissue factor, tissue plasminogen activator, von Willebrand factor, and β-thromboglobulin are important factors involved in the pathogenesis of hypertension. (Source: Current Hypertension Reports)
Source: Current Hypertension Reports - August 10, 2023 Category: Primary Care Source Type: research
Standardizing Blood Pressure Measurements in Pediatric Hemodialysis: a Collaborative Journey
AbstractPurpose of ReviewThis manuscript details the development and execution of a quality improvement (QI) initiative aimed at standardizing blood pressure (BP) measurement practices in pediatric hemodialysis (HD) units across a national dialysis collaborative.Recent FindingsAlthough there are recommendations for the detection and treatment of hypertension in the pediatric population, currently there is no data or recommendations specific to the methodology of measuring blood pressure in a pediatric hemodialysis setting.SummaryIn 2016, the Standardizing Care to Improve Outcomes in Pediatric End Stage Kidney Disease (SCOP...
Source: Current Hypertension Reports - July 28, 2023 Category: Primary Care Source Type: research
