Closed analyser lids do not reduce the measurement uncertainty of serum total carbon dioxide
Ann Clin Biochem. 2023 Nov 18:45632231216598. doi: 10.1177/00045632231216598. Online ahead of print.NO ABSTRACTPMID:37978867 | DOI:10.1177/00045632231216598 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - November 18, 2023 Category: Biochemistry Authors: Francesca Borrillo Alessia Capoferri Leila Rovegno Mauro Panteghini Source Type: research
Closed analyser lids do not reduce the measurement uncertainty of serum total carbon dioxide
Ann Clin Biochem. 2023 Nov 18:45632231216598. doi: 10.1177/00045632231216598. Online ahead of print.NO ABSTRACTPMID:37978867 | DOI:10.1177/00045632231216598 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - November 18, 2023 Category: Biochemistry Authors: Francesca Borrillo Alessia Capoferri Leila Rovegno Mauro Panteghini Source Type: research
Closed analyser lids do not reduce the measurement uncertainty of serum total carbon dioxide
Ann Clin Biochem. 2023 Nov 18:45632231216598. doi: 10.1177/00045632231216598. Online ahead of print.NO ABSTRACTPMID:37978867 | DOI:10.1177/00045632231216598 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - November 18, 2023 Category: Biochemistry Authors: Francesca Borrillo Alessia Capoferri Leila Rovegno Mauro Panteghini Source Type: research
Closed analyser lids do not reduce the measurement uncertainty of serum total carbon dioxide
Ann Clin Biochem. 2023 Nov 18:45632231216598. doi: 10.1177/00045632231216598. Online ahead of print.NO ABSTRACTPMID:37978867 | DOI:10.1177/00045632231216598 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - November 18, 2023 Category: Biochemistry Authors: Francesca Borrillo Alessia Capoferri Leila Rovegno Mauro Panteghini Source Type: research
The role of nutrition and oxidative stress as aging factors in < em > Caenorhabditis elegans < /em >
J Clin Biochem Nutr. 2023 Nov;73(3):173-177. doi: 10.3164/jcbn.23-44. Epub 2023 Jul 6.ABSTRACTThe molecular mechanism of aging, which has been a "black box" for many years, has been elucidated in recent years, and the nematode C. elegans, which is a model animal for aging research, has played a major role in its elucidation. From the analysis of C. elegans longevity-related mutant genes, many signal transduction systems, with the insulin/insulin-like growth factor signal transduction system at the core, have emerged. It has become clear that this signal transduction system is greatly affected by external nutrients and is i...
Source: Clinical Biochemistry - November 16, 2023 Category: Biochemistry Authors: Kayo Yasuda Masaki Miyazawa Takamasa Ishii Naoaki Ishii Source Type: research
Knockdown of LRRK2 inhibits the progression of lung cancer by regulating TLR4/NF- κB pathways and NLRP3 inflammasome
In conclusion, this study suggested that the mechanism of si-LRRK2 inhibiting the progression of lung cancer is to regulate the TLR4/NF-κB signaling pathways and NLRP3 inflammasome.PMID:37970545 | PMC:PMC10636582 | DOI:10.3164/jcbn.22-122 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - November 16, 2023 Category: Biochemistry Authors: Junfang Wu Shumei Yang Hua Wu Yongcheng Huang Yi Miao Source Type: research
Acute effect of proprotein convertase subtilisin/kexin type 9 inhibitor on oxidized low-density lipoprotein and lipid profile in patients at cardiovascular risk
In conclusion, PCSK9 inhibitors reduce ox-LDL levels in very high-risk ASCVD patients in a short time.PMID:37970546 | PMC:PMC10636578 | DOI:10.3164/jcbn.23-45 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - November 16, 2023 Category: Biochemistry Authors: Yiming Li Minni Sun Ran Li Min Dou Haozhe Dong Liqi Xue Guoju Sun Source Type: research
Letter to the Editor: Increased uric acid levels following fructose consumption: a biochemical perspective
J Clin Biochem Nutr. 2023 Nov;73(3):262. doi: 10.3164/jcbn.23-72L. Epub 2023 Nov 1.NO ABSTRACTPMID:37970547 | PMC:PMC10636572 | DOI:10.3164/jcbn.23-72L (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - November 16, 2023 Category: Biochemistry Authors: Sarita Anil Shinde Source Type: research
Association between reactive oxygen species production in neutrophils and liver fibrosis in the general population
J Clin Biochem Nutr. 2023 Nov;73(3):214-220. doi: 10.3164/jcbn.23-46. Epub 2023 Jul 25.ABSTRACTFibrosis, induced by reactive oxygen species (ROS) production in neutrophils, has harmful effects on the liver and various other organs. However, little is known about the association between liver fibrosis and ROS levels in neutrophils in the general population. This large-scale epidemiological study aimed to determine the association between liver fibrosis and neutrophil-generated ROS levels according to age and sex in the general population. This cross-sectional study included 1,000 participants from a district health promotio...
Source: Clinical Biochemistry - November 16, 2023 Category: Biochemistry Authors: Satoshi Sato Shigeyuki Nakaji Kaori Sawada Naoki Akimoto Tetsuyuki Tateda Masatoshi Kaizuka Takafumi Sasada Hiroki Nomiya Go Igarashi Chikara Iino Daisuke Chinda Tatsuya Mikami Hirotake Sakuraba Shinsaku Fukuda Source Type: research
Association of lysophosphatidic acid molecules with liver fibrosis: different roles indicated
In conclusion, the degree of association varied among the different LPA molecule chemical forms, suggesting different pathophysiological roles of individual LPA molecules, although total LPA concentration was shown to be associated with liver fibrosis.PMID:37970549 | PMC:PMC10636581 | DOI:10.3164/jcbn.23-58 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - November 16, 2023 Category: Biochemistry Authors: Hiroshi Tobita Hiromichi Sakai Akane Yamaguchi Yoshitomo Notsu Masatoshi Kataoka Tomotaka Yazaki Toru Nabika Shunji Ishihara Hironori Kobayashi Source Type: research
Humoral and cellular factors inhibit phosphate-induced vascular calcification during the growth period
J Clin Biochem Nutr. 2023 Nov;73(3):198-204. doi: 10.3164/jcbn.23-11. Epub 2023 Jun 28.ABSTRACTHyperphosphatemia is an independent and non-classical risk factor of cardiovascular disease and mortality in patients with chronic kidney disease (CKD). Increased levels of extracellular inorganic phosphate (Pi) are known to directly induce vascular calcification, but the detailed underlying mechanism has not been clarified. Although serum Pi levels during the growth period are as high as those observed in hyperphosphatemia in adult CKD, vascular calcification does not usually occur during growth. Here, we have examined whether t...
Source: Clinical Biochemistry - November 16, 2023 Category: Biochemistry Authors: Yuki Kamei Yosuke Okumura Yuichiro Adachi Yuki Mori Maiko Sakai Kohta Ohnishi Hirokazu Ohminami Masashi Masuda Hisami Yamanaka-Okumura Yutaka Taketani Source Type: research
Inhibition of ALA dehydratase activity in heme biosynthesis reduces cytoglobin expression which is related to the proliferation and viability of keloid fibroblasts
In conclusion, the use of succinyl acetone at a concentration of 1; 2.5; and 5 mM caused decrease ALAD enzyme activity which indicated the inhibition of the heme synthesis. Inhibition of heme synthesis can affect cytoglobin expression, which correlates with the viability and proliferation of keloid fibroblasts.PMID:37970551 | PMC:PMC10636574 | DOI:10.3164/jcbn.23-25 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - November 16, 2023 Category: Biochemistry Authors: Raisa Nauli Septelia I Wanandi Mohamad Sadikin Radiana D Antarianto Sri Widia A Jusman Source Type: research
Combined fructose and sucrose consumption from an early age aggravates cardiac oxidative damage and causes a dilated cardiomyopathy in SHR rats
J Clin Biochem Nutr. 2023 Nov;73(3):205-213. doi: 10.3164/jcbn.23-2. Epub 2023 Aug 9.ABSTRACTObesity increases the risk of arterial hypertension in young adults and favors an early-onset cardiomyopathy by generating oxidative stress. In this sense, indiscriminate consumption of sucrose and fructose sweetened beverages from early ages causes obesity, however its consequences on the heart when there is a genetic predisposition to develop hypertension are not clear. We compared the effects of sucrose, fructose, and their combination in weanling male spontaneously hypertensive rats to determine the relationship between genetic...
Source: Clinical Biochemistry - November 16, 2023 Category: Biochemistry Authors: David Julian Arias-Ch ávez Patrick Mailloux-Salinas Jessica Ledesma Aparicio Guadalupe Bravo Norma Leticia G ómez-Viquez Source Type: research
The significance of CDT1 expression in non-cancerous and cancerous liver in cases with hepatocellular carcinoma
This study aimed to clarify the clinical significance or pathogenesis of CDT1 expression in both non-cancerous and cancerous liver in HCC cases, including previously published data. We investigated the association between the expression of CDT1 in non-cancerous or cancerous liver tissues and histologic findings or biochemical examination results in 62 cases. We also examined the dual localization between CDT1 and FbxW7, P57kip2, P53 and c-Myc by confocal laser scanning microscopy. CDT1 mRNA expression was significantly higher in cancerous liver than in non-cancerous liver (p<0.0001). Elevated CDT1 mRNA expression indica...
Source: Clinical Biochemistry - November 16, 2023 Category: Biochemistry Authors: Masahiro Ogawa Mitsuhiko Moriyama Yutaka Midorikawa Hitomi Nakamura Toshikatu Shibata Kazumichi Kuroda Hisashi Nakayama Kazunori Kanemaru Toshio Miki Masahiko Sugitani Tadatoshi Takayama Source Type: research
The efficacy of hydrogen/oxygen therapy favored the recovery of omicron SARS-CoV-2 variant infection: results of a multicenter, randomized, controlled trial
J Clin Biochem Nutr. 2023 Nov;73(3):228-233. doi: 10.3164/jcbn.23-32. Epub 2023 Aug 18.ABSTRACTClinical studies had found that hydrogen/oxygen mixed inhalation was beneficial to ameliorate the respiratory symptoms in the adjuvant treatment of patients with COVID-19. We aimed to explore the efficacy of hydrogen/oxygen therapy in favoring the recovery of Omicron SARS-CoV-2 variant infection. There were 64 patients who randomly assigned to receive hydrogen/oxygen inhalation (32 patients) and oxygen inhalation (32 patients). The average shedding duration of Omicron in hydrogen/oxygen group was shorter than oxygen group. The tr...
Source: Clinical Biochemistry - November 16, 2023 Category: Biochemistry Authors: Meng-Meng Shi Yun-Tian Chen Xiao-Dan Wang Yun-Feng Zhang Ting Cheng Hui Chen Feng Sun Hong Bao Rong Chen Wei-Ning Xiong Yuan-Lin Song Qing-Yun Li Jie-Ming Qu Source Type: research
