Response to the Letter
J Clin Biochem Nutr. 2023 Nov;73(3):263. doi: 10.3164/jcbn.23-72R. Epub 2023 Nov 1.NO ABSTRACTPMID:37970555 | PMC:PMC10636579 | DOI:10.3164/jcbn.23-72R (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - November 16, 2023 Category: Biochemistry Authors: Hidekazu Arai Source Type: research
Induction of < em > MYCN < /em > -amplified neuroblastoma differentiation through NMYC suppression using PPAR- γ antagonist
J Clin Biochem Nutr. 2023 Nov;73(3):191-197. doi: 10.3164/jcbn.23-28. Epub 2023 Jun 28.ABSTRACTNeuroblastomas are the most common extracranial solid tumors in children and have a unique feature of neuronal differentiation. Peroxisome proliferator-activated receptor (PPAR)-γ is reported to have neuroprotective effects in addition to having antitumor effects in various cancers. Thus, we aimed to clarify the role of PPAR-γ agonist and antagonist in malignant neuroblastomas, which also possess neuronal features. In MYCN-amplified neuroblastoma CHP212 cells, treatment with the PPAR-γ antagonist GW9662 induced growth inhibiti...
Source: Clinical Biochemistry - November 16, 2023 Category: Biochemistry Authors: Yukako Nakao-Ise Takumi Narita Shingo Miyamoto Motoki Watanabe Takuji Tanaka Yoshihiro Sowa Yosuke Iizumi Mitsuharu Masuda Gen Fujii Yasuko Hirai Toshimasa Nakao Hideki Takakura Michihiro Mutoh Source Type: research
Dietary phosphate disturbs of gut microbiome in mice
J Clin Biochem Nutr. 2023 Nov;73(3):221-227. doi: 10.3164/jcbn.23-9. Epub 2023 Jul 15.ABSTRACTDisorder of phosphate metabolism is a common pathological condition in chronic kidney disease patients. Excessive intake of dietary phosphate deteriorates chronic kidney disease and various complications including cardiovascular and infectious diseases. Recent reports have demonstrated that gut microbiome disturbance is associated with both the etiology and progression of chronic kidney disease. However, the relationship between dietary phosphate and gut microbiome remains unknown. Here, we examined the effects of excessive intake...
Source: Clinical Biochemistry - November 16, 2023 Category: Biochemistry Authors: Naoko Oda Kohei Sugihara Takashi Uebanso Hirokazu Ohminami Kohta Ohnishi Masashi Masuda Hisami Yamanaka-Okumura Yutaka Taketani Source Type: research
Lack of observed interference by therapeutic monoclonal antibodies in select commonly utilized immunoassays
CONCLUSION: These findings demonstrate no detectable tmab interference for the assessed immunoassays using spiked preparations of the tmabs in residual human sera. The findings are limited to the tmabs and immunoassays studied here.PMID:37972806 | DOI:10.1016/j.clinbiochem.2023.110685 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - November 16, 2023 Category: Biochemistry Authors: Kornelia D Galior Paula M Ladwig Melissa R Snyder Alicia Algeciras-Schimnich Joshua A Bornhorst Darci R Block Nikola A Baumann Maria Alice V Willrich Source Type: research
The role of nutrition and oxidative stress as aging factors in < em > Caenorhabditis elegans < /em >
J Clin Biochem Nutr. 2023 Nov;73(3):173-177. doi: 10.3164/jcbn.23-44. Epub 2023 Jul 6.ABSTRACTThe molecular mechanism of aging, which has been a "black box" for many years, has been elucidated in recent years, and the nematode C. elegans, which is a model animal for aging research, has played a major role in its elucidation. From the analysis of C. elegans longevity-related mutant genes, many signal transduction systems, with the insulin/insulin-like growth factor signal transduction system at the core, have emerged. It has become clear that this signal transduction system is greatly affected by external nutrients and is i...
Source: Clinical Biochemistry - November 16, 2023 Category: Biochemistry Authors: Kayo Yasuda Masaki Miyazawa Takamasa Ishii Naoaki Ishii Source Type: research
