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Development of a second-tier method for C4, C5 and C2 acylcarnitine analysis in plasma
CONCLUSION: We developed a qualitative LC-MS/MS method for butyl-ester derivatized acylcarnitines, which can be used as a second-tier method for diagnosis and monitoring of various inborn errors of metabolism in our hospital network.PMID:38048898 | DOI:10.1016/j.clinbiochem.2023.110698 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - December 4, 2023 Category: Biochemistry Authors: Josko Ivica Faisal Adam Lyse Wortel Teresa Kalika Heather Pelly Jeannette Gauthier Murray Potter Source Type: research

Serum human epididymis protein 4 is associated with disease severity in patients with IgA nephropathy
CONCLUSIONS: Serum HE4 levels were significantly associated with both renal function and the pathological classification of patients with IgAN, indicating that HE4 may serve as a promising biomarker for assessing the severity of IgAN.PMID:38048899 | DOI:10.1016/j.clinbiochem.2023.110701 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - December 4, 2023 Category: Biochemistry Authors: Hou-Long Luo Chen He Hao Xue Mingyang Li Ling Ji Yong Xia Source Type: research

Accuracy-based proficiency testing for estradiol measurements
CONCLUSIONS: Improvement in accuracy of estradiol measurements is needed, particularly at low estradiol concentrations. Accuracy-based PT provides unambiguous information about the accuracy of methods/analytical systems.PMID:38043696 | DOI:10.1016/j.clinbiochem.2023.110700 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - December 3, 2023 Category: Biochemistry Authors: Zhimin Tim Cao Robert Rej Hubert Vesper J Rex Astles Source Type: research

Case report: Skin protective barrier cream interference in benzethonium chloride method for urine protein measurement in a 6-month-old girl
Ann Clin Biochem. 2023 Nov 26:45632231218833. doi: 10.1177/00045632231218833. Online ahead of print.ABSTRACTThis case report describes the positive interference of the commonly used skin protective barrier cream used together with urine collection bags on the benzethonium chloride method for urine protein measurements in a 6-month-old female baby, leading to falsely elevated results. The interference was identified by both artificially mixing urine samples with this cream and comparing the results obtained using the benzethonium chloride method with those obtained using the pyrogallol red method.PMID:38008911 | DOI:10.1177...
Source: Clinical Biochemistry - November 27, 2023 Category: Biochemistry Authors: Ömer Özcan Joanna Ae van Wijk Annet M Bosch Wendy Pj den Elzen Annemieke C Heijboer Johan C Fischer Source Type: research

Comment on the article titled "Serum cystatin C is associated with peripheral artery stiffness in patients with type 2 diabetes mellitus combined with chronic kidney disease"
Clin Biochem. 2023 Nov 23;123:110699. doi: 10.1016/j.clinbiochem.2023.110699. Online ahead of print.NO ABSTRACTPMID:38006925 | DOI:10.1016/j.clinbiochem.2023.110699 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - November 25, 2023 Category: Biochemistry Authors: Mehmet Ilkin Naharci Source Type: research

The liver-heart axis in patients with severe obesity: the association between liver fibrosis and chronic myocardial injury may be explained by shared risk factors of cardiovascular disease
CONCLUSIONS: Contrary to our hypothesis, ELF score did not predict myocardial injury and fibrosis, but rather demonstrated that an association between liver fibrosis and myocardial injury and fibrosis may be explained by shared risk factors of cardiovascular disease.PMID:37995847 | DOI:10.1016/j.clinbiochem.2023.110688 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - November 23, 2023 Category: Biochemistry Authors: J Young K A Seeberg K M Aakre H Borgeraas N Nordstrand T Wisl øff J Hjelmes æth T Omland J K Hertel Source Type: research

Implementation of Point-of-Care HbA1C instruments into Community Pharmacies: Initial development of a pathway for robust community testing
CONCLUSION: POC HbA1c analysers can be successfully established in community pharmacies. The target patient group responded positively to the opportunity to use a pharmacy service.PMID:37996254 | DOI:10.1177/00045632231219380 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - November 23, 2023 Category: Biochemistry Authors: Andrew Radley Lewis Beer Danya Rushdi Hazel Close Stephen McBurney Adrian Mackenzie Anna Gourlay Anna Barnett Alison Grant Neil Greig Ellie Dow Calum Sutherland Source Type: research