Increased serum SGLT2 and its potential diagnostic and prognostic value in patients with acute ischemic stroke
CONCLUSIONS: The serum SGLT2 concentration may be a potential biomarker for the diagnosis of AIS. However, it does not exhibit any association with disease severity or functional prognosis.PMID:38373585 | DOI:10.1016/j.clinbiochem.2024.110733 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - February 19, 2024 Category: Biochemistry Authors: Yuhan Dong Bo Long Zhanglin Tian Junmeng Huang Youdong Wei Source Type: research
Serial high sensitivity troponin sampling in patients with SARS-CoV-2 infection
CONCLUSIONS: Patients hospitalized with COVID-19 with myocardial injury have higher odds of death. Serial hs-cTn testing provides additional risk stratification in these patients.PMID:38364931 | DOI:10.1016/j.clinbiochem.2024.110732 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - February 16, 2024 Category: Biochemistry Authors: Ronstan Lobo Laura De Michieli Grant M Spears Elitza S Theel Leslie J Donato Amy M Wockenfus Brandon R Kelley Allan S Jaffe Source Type: research
Serial high sensitivity troponin sampling in patients with SARS-CoV-2 infection
CONCLUSIONS: Patients hospitalized with COVID-19 with myocardial injury have higher odds of death. Serial hs-cTn testing provides additional risk stratification in these patients.PMID:38364931 | DOI:10.1016/j.clinbiochem.2024.110732 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - February 16, 2024 Category: Biochemistry Authors: Ronstan Lobo Laura De Michieli Grant M Spears Elitza S Theel Leslie J Donato Amy M Wockenfus Brandon R Kelley Allan S Jaffe Source Type: research
Serial high sensitivity troponin sampling in patients with SARS-CoV-2 infection
CONCLUSIONS: Patients hospitalized with COVID-19 with myocardial injury have higher odds of death. Serial hs-cTn testing provides additional risk stratification in these patients.PMID:38364931 | DOI:10.1016/j.clinbiochem.2024.110732 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - February 16, 2024 Category: Biochemistry Authors: Ronstan Lobo Laura De Michieli Grant M Spears Elitza S Theel Leslie J Donato Amy M Wockenfus Brandon R Kelley Allan S Jaffe Source Type: research
Imprecision of high-sensitivity cardiac troponin assays at the female 99th-percentile
CONCLUSIONS: The number of instruments achieving a CV ≤ 10.0 % at the female 99th-percentile URL varies by manufacturer and by instrument. Monitoring assay precision at the female URL is necessary for some assays to ensure optimal use of this threshold in clinical practice.PMID:38360198 | DOI:10.1016/j.clinbiochem.2024.110731 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - February 15, 2024 Category: Biochemistry Authors: Peter A Kavsak Lorna Clark Saranya Arnoldo Amy Lou Jennifer L Shea Shaun Eintracht Andrew W Lyon Vipin Bhayana Laurel Thorlacius Joshua E Raizman Albert Tsui Rose Djiana Michael Chen Yun Huang Ali Haider Ronald A Booth Chris McCudden Paul M Yip Daniel Ber Source Type: research
Imprecision of high-sensitivity cardiac troponin assays at the female 99th-percentile
CONCLUSIONS: The number of instruments achieving a CV ≤ 10.0 % at the female 99th-percentile URL varies by manufacturer and by instrument. Monitoring assay precision at the female URL is necessary for some assays to ensure optimal use of this threshold in clinical practice.PMID:38360198 | DOI:10.1016/j.clinbiochem.2024.110731 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - February 15, 2024 Category: Biochemistry Authors: Peter A Kavsak Lorna Clark Saranya Arnoldo Amy Lou Jennifer L Shea Shaun Eintracht Andrew W Lyon Vipin Bhayana Laurel Thorlacius Joshua E Raizman Albert Tsui Rose Djiana Michael Chen Yun Huang Ali Haider Ronald A Booth Chris McCudden Paul M Yip Daniel Ber Source Type: research
The significance of PCSK-9's level and polymorphism in premature coronary artery disease: Relation to risk and severity
CONCLUSION: Circulating PCSK9 and caspase-3 concentrations were higher in PCAD patients and were associated with CAD severity. The SNPs of PCSK-9 (rs2483205) and OLR-1 (rs11053646) were associated with PCAD and its severity.PMID:38342398 | DOI:10.1016/j.clinbiochem.2024.110729 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - February 11, 2024 Category: Biochemistry Authors: Marwa A Gaber Omnia H M Omar Abdel-Raheim M A Meki Ahmed Y Nassar Ayman K M Hassan Marwan S Mahmoud Source Type: research
A call-to-action for energy conservation and sustainability in the clinical laboratory: Experiences from the University of Padova
CONCLUSIONS: By implementing these practices, this initiative can gradually expand to encompass more green activities in the future.PMID:38336160 | DOI:10.1016/j.clinbiochem.2024.110727 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - February 9, 2024 Category: Biochemistry Authors: Paola Galozzi Laura Sciacovelli Daniela Basso Source Type: research
Dose optimization and target attainment of vancomycin in children
Clin Biochem. 2024 Feb 5:110728. doi: 10.1016/j.clinbiochem.2024.110728. Online ahead of print.ABSTRACTVancomycin is a glycopeptide antibiotic that has been adopted in clinical practice to treat gram-positive infections for more than 70 years. Despite vancomycin's long history of therapeutic use, optimal dose adjustments and pharmacokinetic/pharmacodynamic (PK/PD) target attainment in children are still under debate. Therapeutic drug monitoring (TDM) has been widely integrated into pediatric clinical practice to maximize efficacy and safety of vancomycin treatment. Area under the curve (AUC)-guided TDM has been recently re...
Source: Clinical Biochemistry - February 7, 2024 Category: Biochemistry Authors: Alessia Cafaro Manuela Stella Alessio Mesini Elio Castagnola Giuliana Cangemi Francesca Mattioli Giammarco Baiardi Source Type: research
Elevated levels of β2-microglobulin in cerebrospinal fluid in adult patients with viral encephalitis/meningitis
CONCLUSION: CSF β2-MG may be a potential inflammatory marker for viral encephalitis/meningitis in adult patients diagnosed with viral encephalitis/meningitis.PMID:38316335 | DOI:10.1016/j.clinbiochem.2024.110719 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - February 5, 2024 Category: Biochemistry Authors: Min-Zhi Zhang Qi-Guang Shi Xiao-Yi Xu Yuan Qi Lin-Jie Zhang Ning Zhao Jia Li Li-Min Li Li-Sha Sun Li Yang Source Type: research
Acceptability of plasma ammonia results when samples are not transported and processed under ideal conditions
CONCLUSIONS: Results support MetBioNet guidance that laboratories accept blood samples for ammonia analysis which are not processed under ideal conditions.PMID:38298138 | DOI:10.1177/00045632241232931 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - February 1, 2024 Category: Biochemistry Authors: Ann Bowron Victoria Osgood Source Type: research
High poly- γ-glutamic acid-containing natto improves lipid metabolism and alters intestinal microbiota in mice fed a high-fat diet
J Clin Biochem Nutr. 2024 Jan;74(1):47-56. doi: 10.3164/jcbn.23-35. Epub 2023 Sep 16.ABSTRACTSeveral beneficial effects of poly-γ-glutamic acid (γ-PGA) have been reported. To test whether natto, a fermented soy food rich in γ-PGA, can improve intestinal microbiota content and lipid metabolism in a high-fat diet, we compared the intestinal microbiota content, plasma, liver, and fecal contents, and changes in gene expression in the livers and large intestines of a group of mice fed a high-fat diet supplemented with cooked soybeans (SC group) and a group fed a high-fat diet supplemented with natto (NA group) for 42 days; h...
Source: Clinical Biochemistry - January 31, 2024 Category: Biochemistry Authors: Motoi Tamura Jun Watanabe Tomotsugu Noguchi Takanobu Nishikawa Source Type: research
Miso, fermented soybean paste, suppresses high-fat/high-sucrose diet-induced muscle atrophy in mice
This study investigated the effects of miso, a traditional fermented soybean food in Japan, on muscle mass atrophy. Eight week old male C57BL/6J mice were fed high fat/high sucrose diet with or without miso for 12 weeks. A miso diet increased soleus muscle weights (p<0.05) and reduced intraperitoneal glucose tolerance and insulin tolerance (p<0.05). The miso diet downregulated the Tnfα and Ccl2 expression, related to inflammation, and Trim63 and Fbxo32 expression, related to muscle atrophy, in the soleus muscle (p<0.05). The miso diet increased short-chain fatty acids levels, including acetic, propanoic, and buta...
Source: Clinical Biochemistry - January 31, 2024 Category: Biochemistry Authors: Yoshitaka Hashimoto Takuro Okamura Ryo Bamba Yuta Yoshimura Chihiro Munekawa Ayumi Kaji Akane Miki Saori Majima Takafumi Senmaru Emi Ushigome Hiroshi Takakuwa Ryoichi Sasano Naoko Nakanishi Masahide Hamaguchi Michiaki Fukui Source Type: research
Iron from the gut: the role of divalent metal transporter 1
J Clin Biochem Nutr. 2024 Jan;74(1):1-8. doi: 10.3164/jcbn.23-47. Epub 2023 Oct 17.ABSTRACTMammalian cells contain thousands of metalloproteins and evolved systems to correctly incorporate metal cofactors into their designated sites. Among the transient metals in living cells, iron is the most abundant element that present as an iron sulfur cluster, mono- and dinuclear iron centers or heme for catalytic reactions. Iron homeostasis is tightly regulated by intestinal iron absorption in mammals owing to the lack of an iron excretive transport system, apart from superficial epithelial cell detachment and urinary outflow reabso...
Source: Clinical Biochemistry - January 31, 2024 Category: Biochemistry Authors: Yasumasa Okazaki Source Type: research
Relationship between critical care nutrition and post-intensive care syndrome in surviving ventilated patients with COVID-19: a multicenter prospective observational study
In conclusion, SPN in the acute phase had a positive impact on physical PICS for ventilated patients with COVID-19.PMID:38292118 | PMC:PMC10822758 | DOI:10.3164/jcbn.23-66 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - January 31, 2024 Category: Biochemistry Authors: Kensuke Nakamura Junji Hatakeyama Keibun Liu Kazuma Yamakawa Takeshi Nishida Shinichiro Ohshimo Shigeaki Inoue Satoru Hashimoto Shuhei Maruyama Daisuke Kawakami Yoshitaka Ogata Katsura Hayakawa Hiroaki Shimizu Taku Oshima Tatsuya Fuchigami Osamu Nishida Source Type: research
