Spironolactone metabolite causes falsely increased progesterone in the Abbott Architect immunoassay
CONCLUSIONS: Our investigations are important for individuals who require progesterone measurements using the Architect i2000 immunoassay, especially because it is unlikely for clinicians to order canrenone measurements alongside progesterone measurements for individuals taking spironolactone. Further research is needed to determine whether canrenone can influence progesterone measurements on other immunoassay systems.PMID:38484829 | DOI:10.1016/j.clinbiochem.2024.110747 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - March 14, 2024 Category: Biochemistry Authors: Kwabena A N Sarpong Su Hee Kim Christopher R McCartney Joseph R Wiencek Lindsay A L Bazydlo Source Type: research
Updated adult ferritin reference intervals based on a large, healthy UK sample, measured on Roche Cobas series analysers
Conclusion This study addresses the inconsistency in SF RIs by presenting intervals based on demographic parameters. This approach can potentially enhance the accuracy of interpreting SF levels, assisting clinicians in identifying patients requiring further evaluation.PMID:38485251 | DOI:10.1177/00045632241243026 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - March 14, 2024 Category: Biochemistry Authors: Sam Rodgers Timothy Woolley Joshua Smith Peter Prinsloo Natasha Fernando Source Type: research
Spironolactone metabolite causes falsely increased progesterone in the Abbott Architect immunoassay
CONCLUSIONS: Our investigations are important for individuals who require progesterone measurements using the Architect i2000 immunoassay, especially because it is unlikely for clinicians to order canrenone measurements alongside progesterone measurements for individuals taking spironolactone. Further research is needed to determine whether canrenone can influence progesterone measurements on other immunoassay systems.PMID:38484829 | DOI:10.1016/j.clinbiochem.2024.110747 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - March 14, 2024 Category: Biochemistry Authors: Kwabena A N Sarpong Su Hee Kim Christopher R McCartney Joseph R Wiencek Lindsay A L Bazydlo Source Type: research
Updated adult ferritin reference intervals based on a large, healthy UK sample, measured on Roche Cobas series analysers
Conclusion This study addresses the inconsistency in SF RIs by presenting intervals based on demographic parameters. This approach can potentially enhance the accuracy of interpreting SF levels, assisting clinicians in identifying patients requiring further evaluation.PMID:38485251 | DOI:10.1177/00045632241243026 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - March 14, 2024 Category: Biochemistry Authors: Sam Rodgers Timothy Woolley Joshua Smith Peter Prinsloo Natasha Fernando Source Type: research
Autoimmune central nervous system disorders: Antibody testing and its clinical utility
Clin Biochem. 2024 Mar 8:110746. doi: 10.1016/j.clinbiochem.2024.110746. Online ahead of print.ABSTRACTA rapidly expanding repertoire of neural antibody biomarkers exists for autoimmune central nervous system disorders. Following clinical recognition of an autoimmune CNS disorder, the detection of a neural antibody facilitates diagnosis and informs prognosis and management. This review considers the phenotypes, diagnostic assay methodologies, and clinical utility of neural antibodies in autoimmune CNS disorders. Autoimmune CNS disorders may present with a diverse range of clinical features. Clinical phenotype should inform...
Source: Clinical Biochemistry - March 10, 2024 Category: Biochemistry Authors: Michael Gilligan Christopher McGuigan Andrew McKeon Source Type: research
Using differential mobility spectrometry to improve the specificity of targeted measurements of 2,3-dinor 11 β-Prostaglandin F2α
CONCLUSIONS: Incorporating DMS devices greatly improved the specificity of BPG measurements by LC-MS/MS, as evidenced by the comparison of chromatograms and fragment ion results. Validation studies showed exceptional performance for established analytical metrics, indicating that this technology can be used to minimize the impact of interferences without adversely impacting other aspects of analytical or clinical performance.PMID:38462204 | DOI:10.1016/j.clinbiochem.2024.110745 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - March 10, 2024 Category: Biochemistry Authors: Kayla Moehnke Jennifer Kemp Michelle R Campbell Ravinder J Singh Anne E Tebo Anthony Maus Source Type: research
Autoimmune central nervous system disorders: Antibody testing and its clinical utility
Clin Biochem. 2024 Mar 8:110746. doi: 10.1016/j.clinbiochem.2024.110746. Online ahead of print.ABSTRACTA rapidly expanding repertoire of neural antibody biomarkers exists for autoimmune central nervous system disorders. Following clinical recognition of an autoimmune CNS disorder, the detection of a neural antibody facilitates diagnosis and informs prognosis and management. This review considers the phenotypes, diagnostic assay methodologies, and clinical utility of neural antibodies in autoimmune CNS disorders. Autoimmune CNS disorders may present with a diverse range of clinical features. Clinical phenotype should inform...
Source: Clinical Biochemistry - March 10, 2024 Category: Biochemistry Authors: Michael Gilligan Christopher McGuigan Andrew McKeon Source Type: research
Using differential mobility spectrometry to improve the specificity of targeted measurements of 2,3-dinor 11 β-Prostaglandin F2α
CONCLUSIONS: Incorporating DMS devices greatly improved the specificity of BPG measurements by LC-MS/MS, as evidenced by the comparison of chromatograms and fragment ion results. Validation studies showed exceptional performance for established analytical metrics, indicating that this technology can be used to minimize the impact of interferences without adversely impacting other aspects of analytical or clinical performance.PMID:38462204 | DOI:10.1016/j.clinbiochem.2024.110745 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - March 10, 2024 Category: Biochemistry Authors: Kayla Moehnke Jennifer Kemp Michelle R Campbell Ravinder J Singh Anne E Tebo Anthony Maus Source Type: research
Autoimmune central nervous system disorders: Antibody testing and its clinical utility
Clin Biochem. 2024 Mar 8:110746. doi: 10.1016/j.clinbiochem.2024.110746. Online ahead of print.ABSTRACTA rapidly expanding repertoire of neural antibody biomarkers exists for autoimmune central nervous system disorders. Following clinical recognition of an autoimmune CNS disorder, the detection of a neural antibody facilitates diagnosis and informs prognosis and management. This review considers the phenotypes, diagnostic assay methodologies, and clinical utility of neural antibodies in autoimmune CNS disorders. Autoimmune CNS disorders may present with a diverse range of clinical features. Clinical phenotype should inform...
Source: Clinical Biochemistry - March 10, 2024 Category: Biochemistry Authors: Michael Gilligan Christopher McGuigan Andrew McKeon Source Type: research
Using differential mobility spectrometry to improve the specificity of targeted measurements of 2,3-dinor 11 β-Prostaglandin F2α
CONCLUSIONS: Incorporating DMS devices greatly improved the specificity of BPG measurements by LC-MS/MS, as evidenced by the comparison of chromatograms and fragment ion results. Validation studies showed exceptional performance for established analytical metrics, indicating that this technology can be used to minimize the impact of interferences without adversely impacting other aspects of analytical or clinical performance.PMID:38462204 | DOI:10.1016/j.clinbiochem.2024.110745 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - March 10, 2024 Category: Biochemistry Authors: Kayla Moehnke Jennifer Kemp Michelle R Campbell Ravinder J Singh Anne E Tebo Anthony Maus Source Type: research
Autoimmune central nervous system disorders: Antibody testing and its clinical utility
Clin Biochem. 2024 Mar 8:110746. doi: 10.1016/j.clinbiochem.2024.110746. Online ahead of print.ABSTRACTA rapidly expanding repertoire of neural antibody biomarkers exists for autoimmune central nervous system disorders. Following clinical recognition of an autoimmune CNS disorder, the detection of a neural antibody facilitates diagnosis and informs prognosis and management. This review considers the phenotypes, diagnostic assay methodologies, and clinical utility of neural antibodies in autoimmune CNS disorders. Autoimmune CNS disorders may present with a diverse range of clinical features. Clinical phenotype should inform...
Source: Clinical Biochemistry - March 10, 2024 Category: Biochemistry Authors: Michael Gilligan Christopher McGuigan Andrew McKeon Source Type: research
Using differential mobility spectrometry to improve the specificity of targeted measurements of 2,3-dinor 11 β-Prostaglandin F2α
CONCLUSIONS: Incorporating DMS devices greatly improved the specificity of BPG measurements by LC-MS/MS, as evidenced by the comparison of chromatograms and fragment ion results. Validation studies showed exceptional performance for established analytical metrics, indicating that this technology can be used to minimize the impact of interferences without adversely impacting other aspects of analytical or clinical performance.PMID:38462204 | DOI:10.1016/j.clinbiochem.2024.110745 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - March 10, 2024 Category: Biochemistry Authors: Kayla Moehnke Jennifer Kemp Michelle R Campbell Ravinder J Singh Anne E Tebo Anthony Maus Source Type: research
An association between plasma levels of α2-macroglobulin and α1-antitrypsin in PiMM and PiZZ individuals differing in COPD presentation
CONCLUSION: Combined measurement of plasma AAT and A2MG levels may be of clinical value in assessing the progression of COPD and requires further attention.PMID:38428450 | DOI:10.1016/j.clinbiochem.2024.110736 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - March 1, 2024 Category: Biochemistry Authors: Urszula Lechowicz Beatriz Martinez-Delgado Bin Liu Sabine Wrenger Adriana Rozy Aneta Zdral David S DeLuca Tobias Welte Sabina Janciauskiene Joanna Chorostowska-Wynimko Source Type: research
Evaluation of Cryoprotein Investigation Using A Digital External Quality Assurance Scheme
Ann Clin Biochem. 2024 Mar 1:45632241239805. doi: 10.1177/00045632241239805. Online ahead of print.ABSTRACTRobust preanalytical and analytical processes are critical for the detection of cryoproteins. There is significant variation in practice in the detection, analysis and reporting. A survey in 2007 of 137 laboratories participating in the UK National External Quality Assessment Service (UK NEQAS) (6) quality control program showed significant variation in the laboratory processes which highlighted the need for standardisation of the detection, analysis and reporting of cryoglobulins.The first available EQA scheme aiming...
Source: Clinical Biochemistry - March 1, 2024 Category: Biochemistry Authors: Dina Patel Ravishankar Sargur Joanna Sheldon Rachel Wheeler Carol Stanley Source Type: research
Low serum carnitine level is associated with increased urinary carnitine excretion in late pregnancy
CONCLUSION: Low carnitine level is associated with increased renal excretion during late pregnancy.PMID:38428946 | DOI:10.1177/00045632241239806 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - March 1, 2024 Category: Biochemistry Authors: Yutaro Kobori Satoshi Hirayama Yoshifumi Fukushima Tsuyoshi Ueno Kazumasa Sekihara Atsushi Hori Yuna Horiuchi Shintaro Makino Emiko Nishioka Takashi Miida Source Type: research
