Salivary testosterone changes during oral glucose tolerance tests in overweight and obese men - postprandial or circadian variation?
CONCLUSIONS: SalT decreased postprandially. A concomitant decrease in serum cortisol, prolactin and TSH reflecting diurnal variation offers an alternative explanation for the decrease in SalT independent of food consumption. Further studies are required to determine whether morning temporal changes in SalT are related to food consumption or circadian rhythm or both.PMID:38591370 | DOI:10.1177/00045632241249087 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - April 9, 2024 Category: Biochemistry Authors: Jonathan Fenn Henry Gill Lauren Starbrook Loretta Theresa Ford Hayley Sharrod-Cole Tejas Kalaria Clare Ford Rousseau Gama Source Type: research
Improvement of point of care testing (POCT) device for accurate whole blood glucose measurement in early neonates
CONCLUSION: The study showed that the point-of-care testing device could be improved to allow for accurate whole-blood glucose measurements in the early neonatal period.PMID:38591468 | DOI:10.1177/00045632241249034 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - April 9, 2024 Category: Biochemistry Authors: Kosuke Koyano Makoto Arioka Yasuhiro Nakao Aya Morimoto Masashiro Sugino Hirosuke Morita Shinji Nakamura Sonoko Kondo Yukihiko Konishi Saneyuki Yasuda Takashi Kusaka Source Type: research
Prostate Health Index (PHI) as a triage tool for reducing unnecessary magnetic resonance imaging (MRI) in patients at risk of prostate cancer
CONCLUSION: PHI could represent a reliable noninvasive tool for selecting patients to undergo mpMRI.PMID:38583655 | DOI:10.1016/j.clinbiochem.2024.110759 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - April 7, 2024 Category: Biochemistry Authors: Luisa Agnello Matteo Vidali Giuseppe Salvaggio Francesco Agnello Bruna Lo Sasso Caterina Maria Gambino Marcello Ciaccio Source Type: research
Prostate Health Index (PHI) as a triage tool for reducing unnecessary magnetic resonance imaging (MRI) in patients at risk of prostate cancer
CONCLUSION: PHI could represent a reliable noninvasive tool for selecting patients to undergo mpMRI.PMID:38583655 | DOI:10.1016/j.clinbiochem.2024.110759 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - April 7, 2024 Category: Biochemistry Authors: Luisa Agnello Matteo Vidali Giuseppe Salvaggio Francesco Agnello Bruna Lo Sasso Caterina Maria Gambino Marcello Ciaccio Source Type: research
Age- and sex-specific 99th percentile upper reference limits for high-sensitivity cardiac troponin T in Chinese older people: Real-world data mining
CONCLUSION: This study establishes age- and sex-specific 99th percentile URLs for hs-cTnT in Chinese older individuals, thereby enhancing the accuracy of clinical assessments.PMID:38582381 | DOI:10.1016/j.clinbiochem.2024.110762 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - April 6, 2024 Category: Biochemistry Authors: Qian Zhang Huiyi Chen Meng Wang Huiying Lai Wensong Liu Lijuan Wang Jiaqi Zhang Chuanbao Li Weiyan Zhou Source Type: research
Age- and sex-specific 99th percentile upper reference limits for high-sensitivity cardiac troponin T in Chinese older people: Real-world data mining
CONCLUSION: This study establishes age- and sex-specific 99th percentile URLs for hs-cTnT in Chinese older individuals, thereby enhancing the accuracy of clinical assessments.PMID:38582381 | DOI:10.1016/j.clinbiochem.2024.110762 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - April 6, 2024 Category: Biochemistry Authors: Qian Zhang Huiyi Chen Meng Wang Huiying Lai Wensong Liu Lijuan Wang Jiaqi Zhang Chuanbao Li Weiyan Zhou Source Type: research
The Contribution of Serum Sialic Acid Binding Immunoglobulin-Like Lectin 1(sSIGLEC-1) as an IFN I Signature Biomarker in the Progression of Atherosclerosis in Egyptian Systemic Lupus Erythematosus (SLE) Patients
Indian J Clin Biochem. 2024 Apr;39(2):291-298. doi: 10.1007/s12291-023-01155-y. Epub 2023 Sep 30.ABSTRACTClinical symptoms of systemic lupus erythematosus (SLE), such as atherosclerosis and related cardiovascular diseases, are caused by inflammatory cytokines and endothelial cell damage. The serum sialic acid binding immunoglobulin-like lectin 1 (sSIGLEC-1) is thought to be an alternative biomarker of IFN signature and may have a role in the pathogenesis of atherosclerosis. The aim of the study was to measure the levels of sSIGLEC-1 in the serum of SLE patients in comparison to a control group and examine the associations ...
Source: Clinical Biochemistry - April 5, 2024 Category: Biochemistry Authors: Mohamed Nasser Mary Wadie Alyaa Farid Azza El Amir Source Type: research
Biochemical Significance of miR-155 and miR-375 as Diagnostic Biomarkers and Their Correlation with the NF- κβ/TNF-α Axis in Breast Cancer
This study aimed to investigate serum expression folds of miR-155 and miR-375 and their correlations with NF-κβ and TNF-α in breast cancer patients. The current study was conducted on 183 unrelated female participants. Serum levels of free T3 and T4, as well as expression folds of miR-155 and miR-375, were significantly higher in patients with fibroadenoma and breast cancer, despite TSH being significantly lower. Additionally, the signaling of TNF-alpha and NF-κβ were found to be significantly upregulated in the serum of patients with breast cancer. Up-regulation of miR-155 and miR-375 expression may be diagnostic bio...
Source: Clinical Biochemistry - April 5, 2024 Category: Biochemistry Authors: Sahar A Abdel-Samed Walaa G Hozyen Saeed M Shaaban Nabil A Hasona Source Type: research
Establishment of Age Specific Reference Interval for Aminoacids and Acylcarnitine in Dried Blood Spot by Tandem Mass Spectrometry
This study was proposed to establish age specific reference internal for aminoacids and acylcartinitine in dried blood spot by tandem mass spectrometry. A total of 480 apparently healthy children were enrolled for the study and sub classified into four groups as follows: Group A: 0-1 month, Group B: 1 month-1 year, Group C: 1-5 year and Group D: 5-12 years each having 120 participants. Sample size were calculated as per CLSI approved guidelines. Tables 1 and 2 presents the age-specific percentile distribution of aminoacids and acylcarnitines established from healthy subjects as per rank-based method recommended by the IFCC...
Source: Clinical Biochemistry - April 5, 2024 Category: Biochemistry Authors: B Vinodh Kumar Pramila Kadiyala P Ponmalar Leema Pauline S Srinivasan Source Type: research
Nanocrocin Protective Effects on Paraquat-Induced Oxidative Stress in the MRC-5 Cell Line
This study aimed to investigate the effects of crocin (CCN) and nano crocin (NCCN) on PQ -induced toxicity in the MRC-5 cell line. The results showed that the particle size of NCCN was 140.3 ± 18.0 nm, and the zeta potential of the optimal crocin-loaded niosomes was 23.4 ± 2.8 mV. The NCCN was more effective than CCN in the inhibition of PQ-induced toxicity. Treatment of the MRC-5 cells leads to a decrease in ROS and an increase in SOD, CAT, GPX, and TAC levels in PQ-CCN and PQ-NCCN groups compared with the PQ group. These changes tended to be positively associated with the NCCN compared to CCN. Overall, NCCN was more ef...
Source: Clinical Biochemistry - April 5, 2024 Category: Biochemistry Authors: Akram Oftadeh Harsin Farzin Firozian Amir Nili Ahmadabadi Meysam Soleimani Akram Ranjbar Source Type: research
Therapeutic Potential of Morin Hydrate Against Rifampicin Induced Hepato and Renotoxicity in Albino Wistar Rats: Modulation of Organ Function, Oxidative Stress and Inflammatory Response
Indian J Clin Biochem. 2024 Apr;39(2):197-206. doi: 10.1007/s12291-023-01145-0. Epub 2023 Aug 4.ABSTRACTTuberculosis (TB) is a challenging public health issue, particularly in poor and developing countries. Rifampicin (RIF) is one of the most common first-line anti-TB drugs but it is known for its adverse effects on the hepato-renal system. The present study investigated the efficacy of morin hydrate (MH) in protecting hepato-renal damage inflicted by RIF in rats. RIF (50 mg/kg), and a combination of RIF (50 mg/kg) and MH (50 mg/kg) were administered orally for 4 weeks in rats. Silymarin (50 mg/kg) was used as a positive c...
Source: Clinical Biochemistry - April 5, 2024 Category: Biochemistry Authors: Harvesh Kumar Rana Amit Kumar Singh Abhay Kumar Pandey Source Type: research
Obesity: An Impact with Cardiovascular and Cerebrovascular Diseases
Indian J Clin Biochem. 2024 Apr;39(2):168-178. doi: 10.1007/s12291-023-01157-w. Epub 2023 Oct 13.ABSTRACTThe authors sought to correlate the complex sequel of obesity with various parameters known to develop metabolic syndrome viz. insulin resistance, dyslipidemia, hypertension etc., as these anomalies are linked to vascular atherosclerosis and outbreak of cardiovascular and cerebrovascular diseases. A comprehensive online survey using MEDLINE, Scopus, PubMed and Google Scholar was conducted for relevant journals from 1970 till present time (2023) with key search terms like: 'obesity', 'leptin', type-2 diabetes', 'atherosc...
Source: Clinical Biochemistry - April 5, 2024 Category: Biochemistry Authors: Savi Dutta A K Singhal Varsha Suryan Nimai Chand Chandra Source Type: research
Occupational and Environmental Exposure Influences the Inflammatory (Pro-and Anti-) Status in Benign Prostate Hyperplasia and Prostate Carcinoma Patients: A Retrospective Analysis
Indian J Clin Biochem. 2024 Apr;39(2):241-247. doi: 10.1007/s12291-023-01112-9. Epub 2023 Jan 13.ABSTRACTMultiple diseases and disorders are connected with occupational and environmental exposure risk. It is also well-established that chemicals and chemical mixtures have an influence on the immune cells of humans. This is an important field of research that has been pursued extensively in relation to autoimmune illnesses, allergy/asthma, and lung cancer, but Prostate Carcinoma has received rare reports. Chronic chemical exposure is known to produce inflammation, which is one of the most prominent characteristics of all mal...
Source: Clinical Biochemistry - April 5, 2024 Category: Biochemistry Authors: Shailendra Dwivedi Praveen Sharma Apul Goel Sanjay Khattri Sanjeev Misra Kamlesh Kumar Pant Source Type: research
Identification of Genetic Variants in Exon 4 of TP53 in Lung Carcinoma and in Silico Prediction of Their Significance
Indian J Clin Biochem. 2024 Apr;39(2):276-282. doi: 10.1007/s12291-022-01099-9. Epub 2022 Dec 8.ABSTRACTLung cancer is a severe and the leading cause of cancer related deaths in men and women all over the world. Tumor suppressor protein (TP53) encoded by the TP53 gene which plays a pivotal role in various cellular tumor suppression processes viz cell cycle arrest and apoptosis. Henceforth, the present study was aimed to TP53 exon4 variants from lung carcinoma. Histopathologic and clinically proven 20 patients of lung cancer were enrolled in this study the average age of patients was 45 ± 8 years which categorized as early...
Source: Clinical Biochemistry - April 5, 2024 Category: Biochemistry Authors: Rajendra Prasad Kirti Sharma Karanpreet Bhutani Suvarna Prasad Sunita Manhas Jai Kishan Source Type: research
The Hepatocurative Effects of < em > Zanthoxylum zanthoxyloides < /em > Alkaloids on Tetrachloromethane-Induced Hepatotoxicity on Albino Rats
Indian J Clin Biochem. 2024 Apr;39(2):188-196. doi: 10.1007/s12291-022-01095-z. Epub 2022 Nov 12.ABSTRACTThe study investigated the hepatocurative activity of the bulk alkaloids of Zanthoxylum zanthoxyloides in a tetrachloromethane (CCl4)-induced hepatotoxicity model in rats. The hepatocurative activity of the alkaloids at 200, 400 and 600 mg/kg doses was demonstrated by the assay of both enzymic and non-enzymic parameters. Sections of the liver were also subjected to histological examinations. Mapping techniques and data visualization approaches were adopted in finding relationships between the enzymic and non-enzymic par...
Source: Clinical Biochemistry - April 5, 2024 Category: Biochemistry Authors: Thecla Okeahunwa Ayoka Ngwu Nwachukwu Aloysius Chinedu Ene Chidi Uzoma Igwe Charles Okeke Nnadi Source Type: research
