Detecting TSHR mRNA from peripheral blood of patients with differentiated thyroid cancer rules out nonaggressive cases
CONCLUSIONS: Employing ddPCR for TSHR mRNA improves its measurement by enabling detection in sample volumes common for laboratory testing. The test displays high prognostic performance, showing potential in preoperative risk assessment.PMID:38195090 | DOI:10.1177/00045632241228217 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - January 9, 2024 Category: Biochemistry Authors: Jelena Jankovi ć Miljuš Ur šula Prosenc Zmrzljak Rok Ko šir Milan Jovanovi ć Ilona Đorić Jelena Ron čević Tijana I šić Denčić Sonja Šelemetjev Source Type: research
Atorvastatin-associated myotoxicity: A toxicokinetic review of pharmacogenetic associations to evaluate the feasibility of precision pharmacotherapy
Clin Biochem. 2024 Jan 3:110707. doi: 10.1016/j.clinbiochem.2024.110707. Online ahead of print.ABSTRACTAtorvastatin (ATV) and other statins are highly effective in reducing cholesterol levels. However, in some patients, the development of drug-associated muscle side effects remains an issue as it compromises the adherence to treatment. Since the toxicity is dose-dependent, exploring factors modulating pharmacokinetics (PK) appears fundamental. The purpose of this review aims at reporting the current state of knowledge about the singular genetic susceptibilities influencing the risk of developing ATV muscle adverse events t...
Source: Clinical Biochemistry - January 5, 2024 Category: Biochemistry Authors: Hoste Emilia Haufroid Vincent Deldicque Louise Balligand Jean-Luc Elens Laure Source Type: research
Atorvastatin-associated myotoxicity: A toxicokinetic review of pharmacogenetic associations to evaluate the feasibility of precision pharmacotherapy
Clin Biochem. 2024 Jan 3:110707. doi: 10.1016/j.clinbiochem.2024.110707. Online ahead of print.ABSTRACTAtorvastatin (ATV) and other statins are highly effective in reducing cholesterol levels. However, in some patients, the development of drug-associated muscle side effects remains an issue as it compromises the adherence to treatment. Since the toxicity is dose-dependent, exploring factors modulating pharmacokinetics (PK) appears fundamental. The purpose of this review aims at reporting the current state of knowledge about the singular genetic susceptibilities influencing the risk of developing ATV muscle adverse events t...
Source: Clinical Biochemistry - January 5, 2024 Category: Biochemistry Authors: Hoste Emilia Haufroid Vincent Deldicque Louise Balligand Jean-Luc Elens Laure Source Type: research
Atorvastatin-associated myotoxicity: A toxicokinetic review of pharmacogenetic associations to evaluate the feasibility of precision pharmacotherapy
Clin Biochem. 2024 Jan 3:110707. doi: 10.1016/j.clinbiochem.2024.110707. Online ahead of print.ABSTRACTAtorvastatin (ATV) and other statins are highly effective in reducing cholesterol levels. However, in some patients, the development of drug-associated muscle side effects remains an issue as it compromises the adherence to treatment. Since the toxicity is dose-dependent, exploring factors modulating pharmacokinetics (PK) appears fundamental. The purpose of this review aims at reporting the current state of knowledge about the singular genetic susceptibilities influencing the risk of developing ATV muscle adverse events t...
Source: Clinical Biochemistry - January 5, 2024 Category: Biochemistry Authors: Hoste Emilia Haufroid Vincent Deldicque Louise Balligand Jean-Luc Elens Laure Source Type: research
Rapid and simple quantification of belimumab in human plasma using ultra-high performance liquid chromatography with tandem mass spectrometry
CONCLUSIONS: We have established and validated a method for measuring plasma belimumab concentrations using UHPLC/MS-MS. By measuring plasma belimumab concentrations in more patients, this method is expected to contribute to appropriate use of belimumab.PMID:38176645 | DOI:10.1016/j.clinbiochem.2023.110706 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - January 4, 2024 Category: Biochemistry Authors: Chisato Yoshijima Yosuke Suzuki Ryota Tanaka Hiroyuki Ono Ayako Oda Takashi Ozaki Hirotaka Shibata Hiroki Itoh Keiko Ohno Source Type: research
Rapid and simple quantification of belimumab in human plasma using ultra-high performance liquid chromatography with tandem mass spectrometry
CONCLUSIONS: We have established and validated a method for measuring plasma belimumab concentrations using UHPLC/MS-MS. By measuring plasma belimumab concentrations in more patients, this method is expected to contribute to appropriate use of belimumab.PMID:38176645 | DOI:10.1016/j.clinbiochem.2023.110706 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - January 4, 2024 Category: Biochemistry Authors: Chisato Yoshijima Yosuke Suzuki Ryota Tanaka Hiroyuki Ono Ayako Oda Takashi Ozaki Hirotaka Shibata Hiroki Itoh Keiko Ohno Source Type: research
Assay error detection when using common quality control targets across multiple instruments: an analysis using simulated and real-world data
Conclusions Compared to instrument-specific QC targets, common targets can reduce the probability of detecting changes in individual assay performance and cause one in-control assay to fail QC more frequently than another. Any impact on clinical care requires further investigation.PMID:38172080 | DOI:10.1177/00045632241226916 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - January 3, 2024 Category: Biochemistry Authors: Eric S Kilpatrick Source Type: research
Assay error detection when using common quality control targets across multiple instruments: an analysis using simulated and real-world data
Conclusions Compared to instrument-specific QC targets, common targets can reduce the probability of detecting changes in individual assay performance and cause one in-control assay to fail QC more frequently than another. Any impact on clinical care requires further investigation.PMID:38172080 | DOI:10.1177/00045632241226916 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - January 3, 2024 Category: Biochemistry Authors: Eric S Kilpatrick Source Type: research
Expression profile of microRNAs in patients with decompensated cirrhosis by small RNA deep sequencing
CONCLUSION: The miRNA expression profiles in patients with DCC and LC controls suggested that miR-20b-5p, miR-421, and miR-150-5p could be potential biomarkers and therapeutic targets for this condition.PMID:38159622 | DOI:10.1016/j.clinbiochem.2023.110705 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - December 30, 2023 Category: Biochemistry Authors: Li Zhang Xiang Dong Yuling Zhan Shasha Ma Chuanmiao Liu Yu Gao Source Type: research
Expression profile of microRNAs in patients with decompensated cirrhosis by small RNA deep sequencing
CONCLUSION: The miRNA expression profiles in patients with DCC and LC controls suggested that miR-20b-5p, miR-421, and miR-150-5p could be potential biomarkers and therapeutic targets for this condition.PMID:38159622 | DOI:10.1016/j.clinbiochem.2023.110705 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - December 30, 2023 Category: Biochemistry Authors: Li Zhang Xiang Dong Yuling Zhan Shasha Ma Chuanmiao Liu Yu Gao Source Type: research
Elevated urine norepinephrine levels and alcohol use: A relationship that should be not neglected
Clin Biochem. 2023 Dec 27;123:110704. doi: 10.1016/j.clinbiochem.2023.110704. Online ahead of print.NO ABSTRACTPMID:38158170 | DOI:10.1016/j.clinbiochem.2023.110704 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - December 29, 2023 Category: Biochemistry Authors: Jari Intra Silvia Ippolito Franco Lorenzini Antonio Mauro Maria Concetta Mazzitello Stefano Melzi Adele Cappellani Fabrizio Cappellini Marco Casati Source Type: research
Urine copper by colorimetry
Ann Clin Biochem. 2023 Dec 27:45632231224244. doi: 10.1177/00045632231224244. Online ahead of print.NO ABSTRACTPMID:38149459 | DOI:10.1177/00045632231224244 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - December 27, 2023 Category: Biochemistry Authors: S A Handley T Wanandy Source Type: research
Urine copper by colorimetry
Ann Clin Biochem. 2023 Dec 27:45632231224244. doi: 10.1177/00045632231224244. Online ahead of print.NO ABSTRACTPMID:38149459 | DOI:10.1177/00045632231224244 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - December 27, 2023 Category: Biochemistry Authors: S A Handley T Wanandy Source Type: research
Urine copper by colorimetry
Ann Clin Biochem. 2023 Dec 27:45632231224244. doi: 10.1177/00045632231224244. Online ahead of print.NO ABSTRACTPMID:38149459 | DOI:10.1177/00045632231224244 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - December 27, 2023 Category: Biochemistry Authors: S A Handley T Wanandy Source Type: research
Urine copper by colorimetry
Ann Clin Biochem. 2023 Dec 27:45632231224244. doi: 10.1177/00045632231224244. Online ahead of print.NO ABSTRACTPMID:38149459 | DOI:10.1177/00045632231224244 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - December 27, 2023 Category: Biochemistry Authors: S A Handley T Wanandy Source Type: research
