Diabetic Encephalopathy: Role of Oxidative and Nitrosative Factors in Type 2 Diabetes
Indian J Clin Biochem. 2024 Jan;39(1):3-17. doi: 10.1007/s12291-022-01107-y. Epub 2022 Dec 16.ABSTRACTDiabetes mellitus is a set of complex metabolic disorders characterized by chronic hyperglycaemic condition due to defective insulin secretion (Type 1) and action (Type 2), which leads to serious micro and macro-vascular damage, inflammation, oxidative and nitrosative stress and a deranged energy homeostasis due to imbalance in the glucose and lipid metabolism. Moreover, patient with diabetes mellitus often showed the nervous system disorders known as diabetic encephalopathy. The precise pathological mechanism of diabetic ...
Source: Clinical Biochemistry - January 15, 2024 Category: Biochemistry Authors: Debashree Mazumdar Santosh Singh Source Type: research
An Updated Trial Sequential Meta-analysis of Vitamin D Receptor Gene Polymorphism (Fok1, Bsm1, Taq1 and Apa1) and Risk to Tuberculosis
Indian J Clin Biochem. 2024 Jan;39(1):60-72. doi: 10.1007/s12291-022-01091-3. Epub 2022 Oct 31.ABSTRACTVitamin D receptor (VDR) is one of the most widely studied genes for the Tuberculosis (TB) susceptibility. Several studies have been conducted to establish some association between them but most of the time they are contradictory and underpowered. So, a trial sequential meta-analysis between VDR gene polymorphisms and TB susceptibility can provide a better understanding of the relationship. A meta-analysis was carried out using a total of 17 case-control studies which includes Fok1 (14 Studies), Bsm1 (8 Studies), Apa1 (8 ...
Source: Clinical Biochemistry - January 15, 2024 Category: Biochemistry Authors: Srishti Shah None Priyanka Sadhna Sharma Source Type: research
Molecular Mechanisms in the Etiology of Polycystic Ovary Syndrome (PCOS): A Multifaceted Hypothesis Towards the Disease with Potential Therapeutics
Indian J Clin Biochem. 2024 Jan;39(1):18-36. doi: 10.1007/s12291-023-01130-7. Epub 2023 Mar 18.ABSTRACTAmong the premenopausal women, Polycystic Ovary Syndrome (PCOS) is the most prevalent endocrinopathy affecting the reproductive system and metabolic rhythms leading to disrupted menstrual cycle. Being heterogeneous in nature it is characterized by complex symptomology of oligomennorhoea, excess of androgens triggering masculine phenotypic appearance and/or multiple follicular ovaries. The etiology of this complex disorder remains somewhat doubtful and the researchers hypothesize multisystem links in the pathogenesis of th...
Source: Clinical Biochemistry - January 15, 2024 Category: Biochemistry Authors: Khair Ul Nisa Najeebul Tarfeen Shahnaz Ahmad Mir Ajaz Ahmad Waza Mir Bilal Ahmad Bashir Ahmad Ganai Source Type: research
Irisin and Triglyceride Glucose Index as Markers of Dyslipidemia in Young Adults
Indian J Clin Biochem. 2024 Jan;39(1):136-141. doi: 10.1007/s12291-022-01083-3. Epub 2022 Sep 6.ABSTRACTIrisin, is a new myokine, considered a favorable metabolic factor and inversely associated with non-communicable diseases. The biological activities of irisin are currently unknown; however, they include browning white adipose tissue, insulin sensitivity, and anti-inflammatory and antioxidant effects. Triglyceride glucose index is a notable insulin resistance marker that predicts the risk of metabolic dyslipidemia and cardiovascular risk. The study aimed to evaluate the relation of irisin and Triglyceride glucose index (...
Source: Clinical Biochemistry - January 15, 2024 Category: Biochemistry Authors: M K Nilofer Sagana K A Arul Senghor V M Vinodhini Renuka P Source Type: research
Monosodium Glutamate Even at Low Dose May Affect Oxidative Stress, Inflammation and Neurodegeneration in Rats
Indian J Clin Biochem. 2024 Jan;39(1):101-109. doi: 10.1007/s12291-022-01077-1. Epub 2022 Sep 6.ABSTRACTMonosodium glutamate (MSG) is a widely used flavour enhancer. A daily intake of MSG at high dosage (2000-4000 mg/kg body weight) is reported to be toxic to humans and experimental animals. The present study aims to investigate the toxic effect of oral administration of MSG at low concentrations (30 and 100 mg/kg body weight) by evaluating biochemical parameters of oxidative stress and inflammation in blood; expression of neuroinflammatory gene and histopathological changes in brain on male Wistar rats. The administration...
Source: Clinical Biochemistry - January 15, 2024 Category: Biochemistry Authors: Rashmi Kesherwani Sukanya Bhoumik Raushan Kumar Syed Ibrahim Rizvi Source Type: research
A Novel < em > TPM1 < /em > Mutation Causes Familial Hypertrophic Cardiomyopathy in an Indian Family: Genetic and Clinical Correlation
We present a case of a novel heterozygous TPM1 mutation, NM_001018005.2:c.203A>G, p.Gln68Arg; co-segregating in an Indian family with hypertrophic cardiomyopathy. Our report expands the mutational spectrum of HCM due to TPM1 and provides the correlated cardiac phenotype.PMID:38223010 | PMC:PMC10784234 | DOI:10.1007/s12291-022-01036-w (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - January 15, 2024 Category: Biochemistry Authors: Prabodh Kumar Ganesh Paramasivam Tom Devasia Mukund Prabhu Maneesh K Rai K Prakashini Sandeep Mallya Dinesh Reghunathan A Megha Krishnananda Nayak Rajasekhar Moka Source Type: research
Protein Carbonyl, Lipid Peroxidation, Glutathione and Enzymatic Antioxidant Status in Male Wistar Brain Sub-regions After Dietary Copper Deficiency
Indian J Clin Biochem. 2024 Jan;39(1):73-82. doi: 10.1007/s12291-022-01093-1. Epub 2022 Oct 27.ABSTRACTCopper a quintessential transitional metal is required for development and function of normal brain and its deficiency has been associated with impairments in brain function. The present study investigates the effects of dietary copper deficiency on brain sub-regions of male Wistar rats for 2-, 4- and 6-week. Pre-pubertal rats were divided into four groups: negative control (NC), copper control (CC), pairfed (PF) and copper deficient (CD). In brain sub regions total protein concentration, glutathione concentration and Cu-...
Source: Clinical Biochemistry - January 15, 2024 Category: Biochemistry Authors: Ankita Rajendra Kurup Neena Nair Source Type: research
Determination of the Roles of Endothelial Nitric Oxide Synthase 4VNTR (4a/b), G894T, T786C Gene Variations in the Bladder Cancer Development
Indian J Clin Biochem. 2024 Jan;39(1):92-100. doi: 10.1007/s12291-022-01090-4. Epub 2022 Oct 3.ABSTRACTThe aim of this study is to determine the roles of eNOS gene variations in BCA development. Our study included 91 patients diagnosed with BCA and 91 healthy controls. eNOS 4VNTR (4a/b), T786C and G894T gene variations genotype distributions were determined by PCR and RFLP methods. The significant difference was determined between these groups in terms of eNOS T786C and eNOS G894T gene variations genotype distributions (p < 0.05). TT genotype for G894T gene variation and CC genotype for T786C gene variation were detecte...
Source: Clinical Biochemistry - January 15, 2024 Category: Biochemistry Authors: Arzu Ay Nevra Alkanli Gokhan Cevik Source Type: research
An Intriguing Case of Amyloidosis Leading to PAGE Kidney in a Post Renal Transplant Recipient: A Case Report
Indian J Clin Biochem. 2024 Jan;39(1):146-150. doi: 10.1007/s12291-022-01072-6. Epub 2022 Sep 9.ABSTRACTAmyloidosis is an infiltrative disease where amyloid fibrils get deposited in the organs like kidney, liver and spleen. Amyloid deposition in the kidneys classically meant deposition in the glomeruli and mesangium until 2008 when interstitial amyloid deposits were isolated and named as` Leukocyte cell-derived chemotaxin 2-associated amyloidosis. It is a progressive disease which clinically manifests as slowly progressive renal dysfunction and/or proteinuria. Our case 34 year old renal transplant recipient underwent graft...
Source: Clinical Biochemistry - January 15, 2024 Category: Biochemistry Authors: Sahil Bagai Scienthia Sanjeevani Dinesh Khullar Rajan Duggal Pallavi Prasad Vivek Saxena Source Type: research
Clinical Utility of Pro-inflammatory Oligomeric Glycoprotein Tenascin-C in the Diagnosis of Seropositive and Seronegative Rheumatoid Arthritis
The objective of our study was to evaluate the diagnostic utility of serum Tenascin-C in seropositive and seronegative rheumatoid arthritis patients. We conducted a cross-sectional case control study. Sixty patients who fulfilled the ACR 2010 criteria for rheumatoid arthritis were included in the study. Thirty patients were found to be positive for RF and/or anti-CCP and 30 were negative for both RF and anti-CCP. Thirty age and gender-matched healthy subjects were taken as controls. Serum Tenascin-C was measured by quantitative sandwich enzyme immunoassay technique. The mean serum concentration of Tenascin-C in controls, s...
Source: Clinical Biochemistry - January 15, 2024 Category: Biochemistry Authors: Sachin Dominic K S S Sai Baba N N Sreedevi Arshi Sanober Liza Rajasekhar Siraj Ahmed Khan Noorjahan Mohammed M Vijaya Bhaskar Iyyapu Krishna Mohan Source Type: research
Assessment of Biotransformed Silica Nanoparticle on Blood Glucose Level in Human: An In Vitro Investigation
This study was conducted to biosynthesize and assess the antihyperglycemic property of silica nanoparticles (SiO2-NPs) since they are non-toxic and biocompatible. SiO2-NPs biosynthesized using the endophytic fungus Fusarium oxysporum. In this collaborative study, 26 people, either hyperglycemic or euglycemic, diagnosed at the Endocrinology Outpatients, according to the American Diabetes Association, USA, were recruited. Silica nanoparticles were characterized and assessed for in vitro antihyperglycemic property using blood samples. Particle size distribution based on TEM images confirms that the average size of silica nano...
Source: Clinical Biochemistry - January 15, 2024 Category: Biochemistry Authors: Amit Mukherjee Tanusree Debbarman Sheelu Shafiq Siddiqi Sk Najrul Islam Absar Ahmad M Mujahid Basu Dev Banerjee Source Type: research
Relationship between Cytokines and Metabolic Syndrome Components: Role of Pancreatic-Derived Factor, Interleukin-37, and Tumor Necrosis Factor- α in Metabolic Syndrome Patients
This study aims to explore the relationship between cytokines and tumor necrosis factor-α (TNF-α), pancreatic-derived factor (PANDER), and interleukin (IL-)-37 and the accumulation of MetS components. Eligible participants were divided into four groups as follows: group 1, patients with dyslipidemia; group 2, patients with dyslipidemia and obesity; group 3, patients with dyslipidemia, obesity, and hypertension; and group 4, patients with dyslipidemia, obesity, hypertension, and hyperglycemia. This study exhibited that serum levels of TNF-α and PANDER were significantly elevated (P < 0.001) in the MetS groups, while I...
Source: Clinical Biochemistry - January 15, 2024 Category: Biochemistry Authors: Adel Abdel-Moneim Rania Mahmoud Gamal Allam Basant Mahmoud Source Type: research
Significance of SDC2 and NDRG4 methylation in stool for colorectal cancer diagnosis
CONCLUSIONS: This research confirmed the significance of detection of SDC2 and NDRG4 methylation by using noninvasive samples of stool. More importantly, attributing to their high level and frequency of methylation in stool, SDC2 and NDRG4 could be promising biomarkers for stool-based method for screening and early diagnosis of CRC, especially when combined.PMID:38224931 | DOI:10.1016/j.clinbiochem.2024.110717 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - January 15, 2024 Category: Biochemistry Authors: Lu Long Qian Sun Fang Yang Hui Zhou Yu Wang Changhe Xiao Qing He Bin Yi Source Type: research
Integrating patient-based quality control and patient-based quality assurance
Clin Biochem. 2024 Feb;124:110708. doi: 10.1016/j.clinbiochem.2024.110708. Epub 2024 Jan 11.NO ABSTRACTPMID:38215871 | DOI:10.1016/j.clinbiochem.2024.110708 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - January 12, 2024 Category: Biochemistry Authors: Tony Badrick Tze Ping Loh Source Type: research
Detecting thyrotropin receptor mRNA from peripheral blood of patients with differentiated thyroid cancer rules out non-aggressive cases
CONCLUSIONS: Employing ddPCR for TSHR mRNA improves its measurement by enabling detection in sample volumes common for laboratory testing. The test displays high prognostic performance, showing potential in preoperative risk assessment.PMID:38195090 | DOI:10.1177/00045632241228217 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - January 9, 2024 Category: Biochemistry Authors: Jelena R Jankovi ć Miljuš Ur šula Prosenc Zmrzljak Rok Ko šir Milan Jovanovi ć Ilona Đ Đorić Jelena V Ron čević Tijana M I šić Denčić Sonja A Šelemetjev Source Type: research
